RichardJEvansMD

PubMed

• The intracellular amino terminus plays a dominant role in desensitisation of ATP gated P2X receptor ion channels.
  Allsopp, R.C., Evans, R.J.> ;J Biol Chem. 2011 Dec 30
• Identification of human P2X1 receptor interacting proteins reveals a role of the cytoskeleton in receptor regulation.
  Lalo, U., Roberts, J.A., Evans, R.J.> ;J Biol Chem. 2011 Sep 2
• Cysteine scanning mutagenesis (residues E52-G96) of the human P2X1 receptor for ATP; mapping agonist binding and channel gating.
  Allsopp, R.C., El Ajouz, S., Schmid, R., Evans, R.J.> ;J Biol Chem. 2011 Aug 19
• The P2X1 receptor and platelet function.
  Mahaut-Smith, M. P.,Jones, S.,Evans, R. J.> ;Purinergic Signal. 2011 Sep
• The residual nonadrenergic contractile response to nerve stimulation of the mouse prostate is mediated by acetylcholine but not ATP in a comparison with the mouse vas ...
  White, C.W., Short, J.L., Haynes, J.M., Evans, R.J., Ventura, S.> ;J Pharmacol Exp Ther. 2010 Nov
• Lipid raft association and cholesterol sensitivity of P2X1-4 receptors for ATP: chimeras and point mutants identify intracellular amino-terminal residues involved in l...
  Allsopp, R.C., Lalo, U., Evans, R.J.> ;J Biol Chem. 2010 Oct 22
• P2X1 ion channels promote neutrophil chemotaxis through Rho kinase activation.
  Lecut, C., Frederix, K., Johnson, D. M., Deroanne, C., Thiry, M., Faccinetto, C., Marée, R., Evans, R. J., Volders, P. G., Bours, V., Oury, C.> ;J Immunol. 2009-08-15
• Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors.
  Roberts, J.A., Digby, H.R., Kara, M., El Ajouz, S., Sutcliffe, M.J., Evans, R.J.> ;J Biol Chem. 2008 Jul 18
• Cysteine substitution mutants give structural insight and identify ATP binding and activation sites at P2X receptors.
  Roberts, J.A., Evans, R.J.> ;J Neurosci. 2007 Apr 11
• Contribution of P2X1 receptor intracellular basic residues to channel properties.
  Vial, C., Rigby, R., Evans, R.J.> ;Biochem Biophys Res Commun. 2006 Nov 10
• Endogenous activation of adenosine A1 receptors, but not P2X receptors, during high-frequency synaptic transmission at the calyx of Held.
  Wong, A.C., Billups, B., Johnston, J., Evans, R.J., Forsythe, I.D.> ;J Neurophysiol. 2006 Jun
• Differential sensitivity of human platelet P2X1 and P2Y1 receptors to disruption of lipid rafts.
  Vial, C., Fung, C.E., Goodall, A.H., Mahaut-Smith, M.P., Evans, R.J.> ;Biochem Biophys Res Commun. 2006 May 5
• Disruption of lipid rafts inhibits P2X1 receptor-mediated currents and arterial vasoconstriction.
  Vial, C.,Evans, R. J.> ;J Biol Chem. 2005 Sep 2
• Interplay between P2Y(1), P2Y(12), and P2X(1) receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte repre...
  Tolhurst, G.,Vial, C.,Léon, C.,Gachet, C.,Evans, R. J.,Mahaut-Smith, M. P.> ;Blood. 2005 Sep 1
• Regulation of human recombinant P2X3 receptors by ecto-protein kinase C.
  Wirkner, K., Stanchev, D., Köles, L., Klebingat, M., Dihazi, H., Flehmig, G., Vial, C., Evans, R. J., Fürst, S., Mager, P. P., Eschrich, K., Illes, P.> ;J Neurosci. 2005 Aug 24
• Direct voltage control of signaling via P2Y1 and other Galphaq-coupled receptors.
  Martinez-Pinna, J., Gurung, I.S., Vial, C., Leon, C., Gachet, C., Evans, R.J., Mahaut-Smith, M.P.> ;J Biol Chem. 2005 Jan 14
• Analysis of the membrane topology of the acid-sensing ion channel 2a.
  Saugstad, J.A., Roberts, J.A., Dong, J., Zeitouni, S., Evans, R.J.> ;J Biol Chem. 2004 Dec 31
• Functional characterization of a P2X receptor from Schistosoma mansoni.
  Agboh, K.C., Webb, T.E., Evans, R.J., Ennion, S.J.> ;J Biol Chem. 2004 Oct 1
• Functional regulation of P2X6 receptors by N-linked glycosylation: identification of a novel alpha beta-methylene ATP-sensitive phenotype.
  Jones, C.A., Vial, C., Sellers, L.A., Humphrey, P.A., Evans, R.J., Chessell, I.P.> ;Mol Pharmacol. 2004 Apr
• ATP binding at human P2X1 receptors. Contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonists.
  Roberts, J.A., Evans, R.J.> ;J Biol Chem. 2004 Mar 5
• Heterogeneity of P2X receptors in sympathetic neurons: contribution of neuronal P2X1 receptors revealed using knockout mice.
  Calvert, J.A., Evans, R.J.> ;Mol Pharmacol. 2004 Jan
• Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior.
  Inscho, E.W., Cook, A.K., Imig, J.D., Vial, C., Evans, R.J.> ;J Clin Invest. 2003 Dec
• Lack of evidence for functional ADP-activated human P2X1 receptors supports a role for ATP during hemostasis and thrombosis.
  Vial, C., Pitt, S.J., Roberts, J., Rolf, M.G., Mahaut-Smith, M.P., Evans, R.J.> ;Blood. 2003 Nov 15
• P2X(1) receptor-deficient mice establish the native P2X receptor and a P2Y6-like receptor in arteries.
  Vial, C., Evans, R.J.> ;Mol Pharmacol. 2002 Dec
• P2X(1) receptor subunit contribution to gating revealed by a dominant negative PKC mutant.
  Ennion, S.J., Evans, R.J.> ;Biochem Biophys Res Commun. 2002 Mar 1
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