RichardDaleHuhnMD

PubMed

• 10 citations
  Immune Pharmacodynamic Responses of the Novel Cancer Immunotherapeutic Imprime PGG in Healthy Volunteers.
  Nandita Bose, Nadine R. Ottoson, Xiaohong Qiu, Ben Harrison, Jamie Lowe, Mark T. Uhlik, Blaine Rathmann, Takashi O Kangas, Lindsay R Jordan, Kathleen E. Ertelt, Adria ...> ;Journal of Immunology. 2019 May 15
• 12 citations
  A randomized, controlled trial evaluating the efficacy and safety of BTH1677 in combination with bevacizumab, carboplatin, and paclitaxel in first-line treatment of ad...
  Walburga Engel-Riedel, Jamie Lowe, Paulette Mattson, J. Richard Trout, Richard D. Huhn, Michele Gargano, Myra L. Patchen, Richard Walsh, My My Trinh, Mariève Dupuis, F...> ;Journal for Immunotherapy of Cancer. 2018 Feb 27
• 14 citations
  Combination anti-CD137 and anti-CD40 antibody therapy in murine myc-driven hematological cancers.
  Jennifer A. Westwood, Geoffrey M. Matthews, Jake Shortt, David Faulkner, Hollie J Pegram, Connie P.M. Duong, Marta Chesi, P. Leif Bergsagel, Leslie L. Sharp, Richard D...> ;Leukemia Research. 2014 Aug 1
• 1189 citations
  CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans
  Gregory L. Beatty, Elena G. Chiorean, Matthew P. Fishman, Babak Saboury, Ursina R. Teitelbaum, Weijing Sun, Richard D. Huhn, Wenru Song, Dongguang Li, Leslie L. Sharp,...> ;Science. 2011 Mar 25
• 118 citations
  Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumors.
  Jens Rüter, Scott J. Antonia, Howard A. Burris, Richard D. Huhn, Robert H. Vonderheide> ;Cancer Biology & Therapy. 2010 Nov 15
• 393 citations
  Clinical Activity and Immune Modulation in Cancer Patients Treated With CP-870,893, a Novel CD40 Agonist Monoclonal Antibody
  Robert H. Vonderheide, Keith T. Flaherty, Magi Khalil, Molly S. Stumacher, David L. Bajor, Natalie A. Hutnick, Patricia Sullivan, J. Joseph Mahany, Maryann Gallagher, ...> ;Journal of Clinical Oncology. 2007 Mar 1
• Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody.
  Vonderheide RH, Flaherty KT, Khalil M, Stumacher MS, Bajor DL, Gallagher M, Sullivan P, Mahaney JJ, O'Dwyer PJ, Huhn RD, Antonia SJ> ;J. Clin. Oncol.. 2006-06-20
• 75 citations
  High-dose cyclophosphamide with autologous lymphocyte–depleted peripheral blood stem cell (PBSC) support for treatment of refractory chronic autoimmune thrombocytopenia
  Richard D. Huhn, Patrick F. Fogarty, Ryotaro Nakamura, Elizabeth J. Read, Susan F. Leitman, Margaret E. Rick, Janice Kimball, Adeira Greene, Kristin Hansmann, A. Gratw...> ;Blood. 2003 Jan 1
• 62 citations
  Retroviral marking and transplantation of rhesus hematopoietic cells by nonmyeloablative conditioning.
  Richard D. Huhn, John F. Tisdale, Brian A. Agricola, Mark E. Metzger, Robert E. Donahue, Cynthia E. Dunbar> ;Human Gene Therapy. 1999 Jul 20
• 13 citations
  Effects of single intravenous doses of recombinant human interleukin-10 on subsets of circulating leukocytes in humans.
  Richard D. Huhn, Kenneth Pennline, Elaine Radwanski, Laura Clarke, Ron Sabo, David L. Cutler> ;Immunopharmacology. 1999 Feb 1
• 47 citations
  Pharmacokinetics and leukocyte responses of recombinant human interleukin-10.
  Elaine Radwanski, Abhijit Chakraborty, Scott A. Van Wart, Richard D. Huhn, David L. Cutler, Melton B. Affrime, William J. Jusko> ;Pharmaceutical Research. 1998 Dec 1
• 2 citations
  Staphylococcal Psoas Abscess
  Richard D. Huhn, Harish P. Dave> ;The New England Journal of Medicine. 1998 Aug 20
• 85 citations
  Pharmacodynamics of subcutaneous recombinant human interleukin‐10 in healthy volunteers
  Richard D. Huhn, Elaine Radwanski, Jose Gallo, Melton B. Affrime, Ron Sabo, Gerilyn Gonyo, April Monge, Cutler David L> ;Clinical Pharmacology and Therapeutics. 1997 Aug 1
• 13 citations
  Pharmacokinetics of intravenous recombinant human granulocyte colony-stimulating factor (rhG-CSF) in children receiving myelosuppressive cancer chemotherapy: clearance...
  Marc G. Sturgill, Richard D. Huhn, Richard A. Drachtman, Alice G. Ettinger, Lawrence J. Ettinger> ;American Journal of Hematology. 1997 Feb 1
• 33 citations
  Recombinant human interleukin-3 (rhIL-3) enhances the mobilization of peripheral blood progenitor cells by recombinant human granulocyte colony-stimulating factor (rhG...
  Richard D. Huhn, E J Yurkow, R Tushinski, L Clarke, M G Sturgill, R Hoffman, W Sheay, R Cody, C Philipp, D Resta, M George> ;Experimental Hematology. 1996 Jun 1
• Epirubicin and ifosfamide in metastatic breast cancer.
  Becher R, Kloke O, Hayungs J, Hartwich G, Bartels H, Szanto J, Wolf E, Illiger HJ, Halabi S, Rieche K, Hering KG, Ohl S, DeDycker R, Huhn R, Fischedick AR, Höfeler H, ...> ;Semin. Oncol.. 1996-06-01
• 112 citations
  Pharmacokinetics and immunomodulatory properties of intravenously administered recombinant human interleukin-10 in healthy volunteers
  Richard D. Huhn, Elaine Radwanski, Sean M. O'Connell, Marc G. Sturgill, Laura Clarke, Ronald P. Cody, Melton B. Affrime, Cutler David L> ;Blood. 1996 Jan 15
• Concurrent presentation of erythrocytic and megakaryocytic aplasia.
  Brian F. Canavan, Richard D. Huhn, Hugh C. Kim, Martin Kosmin, Wendy Sheay, Parvin Saidi> ;American Journal of Hematology. 1996 Jan 1
• 8 citations
  Pharmacodynamics of daily subcutaneous recombinant human interleukin-3 in normal volunteers
  Richard D. Huhn, Edward J. Yurkow, John G. Kuhn, Laura Clarke, Han Gunn, Debra Resta, Reena Shah, Laurie A. Myers, James R. Seibold> ;Clinical Pharmacology and Therapeutics. 1995 Jan 1
• 29 citations
  Evaluation of granulocyte-macrophage colony-stimulating factor for treatment of pancytopenia in children with fanconi anemia.
  Eva C. Guinan, Karen Dunn Lopez, Richard D. Huhn, James M. Felser, David G. Nathan> ;The Journal of Pediatrics. 1994 Jan 1
• 19 citations
  Effects of 1α,25-dihydroxyvitamin D3 on the human chronic myelogenous leukemia cell line RWLeu-4.
  Stephen R. Lasky, William Bell, Richard D. Huhn, Marshall R. Posner, Michael C. Wiemann, Paul Calabresi, Charles Eil> ;Cancer Research. 1990 May 15
• 94 citations
  Stimulation of factor-dependent myeloid cell lines with interleukin 3 induces tyrosine phosphorylation of several cellular substrates.
  R Isfort, Richard D. Huhn, Frackelton Ar, J N Ihle> ;The Journal of Biological Chemistry. 1988 Dec 15
• 50 citations
  Cell lines and peripheral blood leukocytes derived from individuals with chronic myelogenous leukemia display virtually identical proteins phosphorylated on tyrosine r...
  Richard D. Huhn, M. R. Posner, S I Rayter, J G Foulkes, Frackelton Ar> ;Proceedings of the National Academy of Sciences of the United States of America. 1987 Jul 1
• Therapeutic effects and pharmacokinetics of recombinant human granulocyte-macrophage colony-stimulating factor in childhood cancer patients receiving myelosuppressive ...
  Furman, W. L., Fairclough, D. L., Huhn, R. D., Pratt, C. B., Stute, N., Petros, W. P., Evans, W. E., Bowman, L. C., Douglass, E. C., Santana, V. M.> ;J Clin Oncol. 1991 Jun
• Maintenance treatment with medroxyprogesterone acetate in patients with advanced breast cancer responding to chemotherapy: results of a randomized trial. Essen Breast ...
  Kloke, O., Klaassen, U., Oberhoff, C., Hartwich, G., Szanto, J., Wolf, E., Heckmann, M., Huhn, R., Stephan, L., Schnepper, U., Donsbach, G. M., Bechtel, C., Rudolph, R...> ;Breast Cancer Res Treat. 1999 May
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Abstracts/Posters

• A Phase 1 Study Evaluating BI 765063, a First in Class Selective Myeloid Sirpa Inhibitor, As Stand-Alone and in Combination with BI 754091, a Programmed Death-1 (PD-1)...
  Richard D. Huhn, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019