RoyLFreemanMD

Neurology • Boston, MA

Neurophysiology

Professor, Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School

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Office
1 Deaconess Rd
Beth Israel Deaconess Med Ctr Palmer 111
Boston, MA 02215
Phone+1 617-632-8454
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Education & Training

Beth Israel Deaconess Medical Center/Harvard Medical SchoolResidency, Neurology, 1979 - 1982
Brigham and Women's HospitalInternship, Internal Medicine, 1978 - 1979
University of Cape Town Faculty of MedicineClass of 1974

Certifications & Licensure

MA State Medical License 1980 - 2025
American Board of Psychiatry and Neurology Neurology

Clinical Trials

Norepinephrine Transporter Blockade as a Pathological Biomarker in Neurogenic Orthostatic Hypotension Start of enrollment: 2011 Mar 01
Completed
Evaluating the Effectiveness of Intravenous Immunoglobulin Therapy in Autoimmune Autonomic Ganglionopathy Start of enrollment: 2012 Feb 01
Completed
Phase 2, Phase 3
Hypoglycemia and Autonomic Nervous System Function Start of enrollment: 2004 Jun 08
Completed
Not Applicable
The Nutritional Benefits of Metanx in Patients With Diabetic Peripheral Neuropathy (MEDIAN) Start of enrollment: 2013 Nov 01
Unknown status
Not Applicable
Hypoglycemia and Autonomic Nervous System Function- B2 Start of enrollment: 2017 Sep 25
Active, not recruiting
Not Applicable
Hypoglycemia and Autonomic Nervous System Function-B Start of enrollment: 2013 Jul 17
Active, not recruiting
Phase 4
The Functional Neuroanatomy of the Human Physiological Stress Response Start of enrollment: 2019 Oct 01
Recruiting
Not Applicable
A Study of TAK-341 in Treatment of Multiple System Atrophy Start of enrollment: 2022 Nov 09
Recruiting
Phase 2
Roles: Principal Investigator
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Publications & Presentations

PubMed

Skin Biopsy Detection of Phosphorylated α-Synuclein in Patients With Synucleinopathies.
Christopher H Gibbons, Todd Levine, Charles Adler, Bailey Bellaire, Ningshan Wang, Jade Stohl, Pinky Agarwal, Georgina M Aldridge, Alexandru Barboi, Virgilio G H Evide...> ;JAMA. 2024 Mar 20
1 citations
Patient engagement in designing, conducting, and disseminating clinical pain research: IMMPACT recommended considerations.
Haroutounian, S., Holzer, K., Kerns, R., Veasley, C., Dworkin, R., Turk, D., Carman, K., Chambers, C., Cowan, P., Edwards, R., Eisenach, J., Farrar, J., Ferguson, M., ...> ;Pain. 2023 Dec 19
Plasma proteomic analysis on neuropathic pain in idiopathic peripheral neuropathy patients.
Perry T C van Doormaal, Simone Thomas, Senda Ajroud-Driss, Robert N Cole, Lauren R DeVine, Mazen M Dimachkie, Stefanie Geisler, Roy Freeman, David M Simpson, J Robinso...> ;Journal of the Peripheral Nervous System. 2024 Mar 1
Effect of hypoglycemia on baroreflex sensitivity in individuals with type 2 diabetes: implications for autonomic control of cardiovascular function in diabetes.
Andrea V Haas, Andrew Koefoed, Rebecca M Easly, Johanna Celli, Mahyar Heydarpour, Istvan Bonyhay, Roy Freeman, Gail K Adler> ;Clinical Autonomic Research. 2023 Dec 1
4 citations
Efficacy and safety of vixotrigine in idiopathic or diabetes-associated painful small fibre neuropathy (CONVEY): a phase 2 placebo-controlled enriched-enrolment random...
Catharina G Faber, Nadine Attal, Giuseppe Lauria, Robert H Dworkin, Roy Freeman, Katherine T Dawson, Helen Finnigan, Amirhossein Hajihosseini, Himanshu Naik, Michael S...> ;Eclinicalmedicine. 2023 May 1
1 citations
Cannabinoid Therapy: Attitudes and Experiences of People With Chronic Pain.
Jennifer S Gewandter, Robert R Edwards, Kevin P Hill, Ajay D Wasan, Julia E Hooker, Emma C Lape, Soroush Besharat, Penney Cowan, Bernard Le Foll, Joseph W Ditre, Roy F...> ;The Clinical Journal of Pain. 2023 Jun 1
2 citations
Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement.
David J Hohenschurz-Schmidt, Dan Cherkin, Andrew S C Rice, Robert H Dworkin, Dennis C Turk, Michael P McDermott, Matthew J Bair, Lynn L DeBar, Robert R Edwards, John T...> ;Pain. 2023 Jul 1
Two-Year observational study of autonomic skin function in patients with Parkinson's disease compared to healthy individuals.
Timo Siepmann, Martin Arndt, Annahita Sedghi, Szabolcs Szatmári Jr, Tamás Horváth, Annamária Takáts, Dániel Bereczki, Mats Leif Moskopp, Sylvia Buchmann, Cornelia Skow...> ;European Journal of Neurology. 2023 May 1
14 citations
Cutaneous α-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease.
Christopher Gibbons, Ningshan Wang, Sharika Rajan, Drew Kern, Jose-Alberto Palma, Horacio Kaufmann, Roy Freeman> ;Neurology. 2023 Apr 11
Correction to: Clinical trial-ready patient cohorts for multiple system atrophy: coupling biospecimen and iPSC banking to longitudinal deep-phenotyping.
Alain Ndayisaba, Ariana T Pitaro, Andrew S Willett, Kristie A Jones, Claudio Melo de Gusmao, Abby L Olsen, Jisoo Kim, Eero Rissanen, Jared K Woods, Sharan R Srinivasan...> ;Cerebellum. 2024 Feb 1
2 citations
Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping.
Alain Ndayisaba, Ariana T Pitaro, Andrew S Willett, Kristie A Jones, Claudio Melo de Gusmao, Abby L Olsen, Jisoo Kim, Eero Rissanen, Jared K Woods, Sharan R Srinivasan...> ;Cerebellum. 2024 Feb 1
6 citations
Cutaneous amyloid is a biomarker in early ATTRv neuropathy and progresses across disease stages.
Roy Freeman, Alejandra Gonzalez-Duarte, Fabio Barroso, Marta Campagnolo, Sharika Rajan, Jennifer Garcia, Jee Young Kim, Ningshan Wang, Lucas Orellana, Christopher Gibbons> ;Annals of Clinical and Translational Neurology. 2022 Sep 1
4 citations
Stress, hypoglycemia, and the autonomic nervous system.
Andrea Haas, David Borsook, Gail Adler, Roy Freeman> ;Autonomic Neuroscience. 2022 Jul 1
184 citations
The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy.
Gregor K Wenning, Iva Stankovic, Luca Vignatelli, Alessandra Fanciulli, Giovanna Calandra-Buonaura, Klaus Seppi, Jose-Alberto Palma, Wassilios G Meissner, Florian Kris...> ;Movement Disorders. 2022 Jun 1
3 citations
The solitary nucleus connectivity to key autonomic regions in humans.
Julia Forstenpointner, Anne Margarette S Maallo, Igor Elman, Scott Holmes, Roy Freeman, Ralf Baron, David Borsook> ;The European Journal of Neuroscience. 2022 Jul 1
8 citations
Synuclein-One study: skin biopsy detection of phosphorylated α-synuclein for diagnosis of synucleinopathies.
Christopher H Gibbons, Roy Freeman, Bailey Bellaire, Charles H Adler, Dan Moore, Todd Levine> ;Biomarkers in Medicine. 2022 May 1
2 citations
The omnipresence of autonomic modulation in health and disease.
Julia Forstenpointner, Igor Elman, Roy Freeman, David Borsook> ;Progress in Neurobiology. 2022 Mar 1
1 citations
The threshold tracking nerve conduction study technique: Experience of clinical users unfamiliar with a research-grade neuronal excitability system.
C E McIlduff, B J Wainger, R L Freeman, S Samaan, I Yator, H Gutierrez, S Verga, S B Rutkove> ;Clinical Neurophysiology Practice. 2022 Jan 1
2 citations
Effect of adrenocorticotropic hormone infusion on circulating sclerostin levels.
Sarah Zaheer, Kayla M. Meyer, Rebecca M. Easly, Omar Bayomy, Janet H Leung, Andrew W. Koefoed, Mahyar Heydarpour, Roy Freeman, Gail K. Adler> ;Endocrine Connections. 2021 Nov 1
6 citations
Diagnostic criteria for initial orthostatic hypotension: a narrative review.
Daan J.L. van Twist, Mark P. M. Harms, Veera K. van Wijnen, Victoria E. Claydon, Roy Freeman, William P. Cheshire, Wouter Wieling> ;Clinical Autonomic Research. 2021 Oct 22
6 citations
Myeloid Mineralocorticoid Receptor Transcriptionally Regulates P-Selectin Glycoprotein Ligand-1 and Promotes Monocyte Trafficking and Atherosclerosis.
Joshua J. Man, Qing Lu, M. Elizabeth Moss, Brigett Carvajal, Wendy Baur, Amanda E Garza, Roy Freeman, Marina Anastasiou, Njabulo Ngwenyama, Gail K. Adler, Pilar Alcaid...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2021 May 10
1 citations
X-Linked Dystonia-Parkinsonism (“Lubag”) May Present with Peripheral Synucleinopathy
Virgilio Gerald H. Evidente, Danica H. Evidente, Susan C. Ortega, Todd Levine, Roy Freeman, ChristopherH. Gibbons> ;Movement Disorders. 2021 Sep 28
45 citations
Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: International expert consensus recommendations.
Dan Ziegler, Solomon Tesfaye, Vincenza Spallone, Irina Gurieva, Juma Al Kaabi, Boris Mankovsky, Emil Martinka, Gabriela Radulian, Khue Thy Nguyen, Alin Stirban, Tsveta...> ;Diabetes Research and Clinical Practice. 2021 Sep 18
4 citations
Benefit-risk assessment and reporting in clinical trials of chronic pain treatments: IMMPACT recommendations.
Bethea A. Kleykamp, Robert H. Dworkin, Dennis C. Turk, Zubin Bhagwagar, Penney Cowan, Christopher Eccleston, Susan S. Ellenberg, Scott R. Evans, John T. Farrar, Roy Fr...> ;Pain. 2021 Sep 9
21 citations
Randomized, double-blind, placebo-controlled trial of ISC 17536, an oral inhibitor of transient receptor potential ankyrin 1, in patients with painful diabetic periphe...
Sunil M. Jain, Ramanathan Balamurugan, Monika Tandon, Neelufar Mozaffarian, Girish Gudi, Yacine Salhi, Robert Holland, Roy Freeman, Ralf Baron> ;Pain. 2021 Sep 2
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Journal Articles

State-of-the-Art Review
Roy Freeman, Mitchell G Miglis, Christopher Gibbons, Pearl Jones, ScienceDirect

Lectures

Diabetic Peripheral Neuropathy: More Effective Treatments Needed
43rd Annual Meeting, Amsterdam, The Netherlands
Diabetic Peripheral Neuropathy: More Effective Treatments Needed
European Association for the Study of Diabetes, 43rd Annual Meeting, Amsterdam, The Netherlands

Press Mentions

CND Life Sciences Enters into Licensing and Collaboration Agreement to Advance Diagnostic Technology for Neurodegenerative DiseasesMarch 22nd, 2023
NeuroBo Pharmaceuticals Reports Third Quarter 2020 Financial ResultsNovember 13th, 2020
Dizziness Upon Standing Can Lead to Falls and FracturesAugust 31st, 2020
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Hospital Affiliations

Beth Israel Deaconess Medical CenterBoston, Massachusetts