ThomasEScammellMD

PubMed

• What is Cataplexy?
  Margaret S Blattner, Thomas E Scammell> ;Sleep. 2023 Oct 3
• Harriet Tubman's Hypersomnia: Insights from Historical and Medical Perspectives.
  Evan A Balmuth, Thomas E Scammell> ;Journal of General Internal Medicine. 2023 Dec 1
• 6 citations
  Oral Orexin Receptor 2 Agonist in Narcolepsy Type 1.
  Yves Dauvilliers, Emmanuel Mignot, Rafael Del Río Villegas, Yeting Du, Elizabeth Hanson, Yuichi Inoue, Harisha Kadali, Elena Koundourakis, Seetha Meyer, Raquel Rogers,...> ;The New England Journal of Medicine. 2023 Jul 27
• Number, Duration, and Distribution of Wake Bouts in Patients with Insomnia Disorder: Effect of Daridorexant and Zolpidem.
  Tobias Di Marco, Thomas E Scammell, Michael Meinel, Dalma Seboek Kinter, Alexandre N Datta, Gary Zammit, Yves Dauvilliers> ;CNS Drugs. 2023 Jul 1
• 15 citations
  Clinical considerations for the diagnosis of idiopathic hypersomnia.
  Yves Dauvilliers, Richard K Bogan, Isabelle Arnulf, Thomas E Scammell, Erik K St Louis, Michael J Thorpy> ;Sleep Medicine Reviews. 2022 Dec 1
• 1 citations
  Glutamatergic pedunculopontine tegmental neurons control wakefulness and locomotion via distinct axonal projections.
  Daniel Kroeger, Jack Thundercliffe, Alex Phung, Roberto De Luca, Carolyn Geraci, Samuel Bragg, Kayleen J McCafferty, Sathyajit S Bandaru, Elda Arrigoni, Thomas E Scammell> ;Sleep. 2022 Dec 12
• 1 citations
  Major advances in sleep neurology: 2002-22.
  Thomas E Scammell, Clifford B Saper> ;The Lancet. Neurology. 2022 Aug 1
• 19 citations
  Orexin neurons inhibit sleep to promote arousal.
  Roberto De Luca, Stefano Nardone, Kevin P Grace, Anne Venner, Michela Cristofolini, Sathyajit S Bandaru, Lauren T Sohn, Dong Kong, Takatoshi Mochizuki, Bianca Viberti,...> ;Nature Communications. 2022 Jul 18
• Catching Up on REMs.
  Christian R Burgess, Thomas E Scammell> ;The New England Journal of Medicine. 2022 May 19
• 7 citations
  Development and Validation of the Pediatric Hypersomnolence Survey.
  Kiran Maski, Jennifer Worhach, Erin Steinhart, Madeline Boduch, Anne Marie Morse, Michael Strunc, Thomas Scammell, Judith Owens, Lindsay Jesteadt, Claire Crisp, David ...> ;Neurology. 2022 May 10
• 5 citations
  Circadian Rhythms and Sleep Are Dependent Upon Expression Levels of Key Ubiquitin Ligase.
  Shu-Qun Shi, Carrie E Mahoney, Pavel Houdek, Wenling Zhao, Matthew P Anderson, Xinming Zhuo, Arthur Beaudet, Alena Sumova, Thomas E Scammell, Carl Hirschie Johnson> ;Frontiers in Behavioral Neuroscience. 2022 Jan 1
• 15 citations
  Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.
  Xing Xiao, Gagik Yeghiazaryan, Simon Hess, Paul Klemm, Anna Sieben, André Kleinridders, Donald A. Morgan, F. Thomas Wunderlich, Kamal Rahmouni, Dong Kong, Thomas E. Sc...> ;Nature Communications. 2021 Sep 2
• 5 citations
  Input-output connections of LJA5 prodynorphin neurons.
  Lindsay J Agostinelli, Madison R Mix, Marco M. Hefti, Thomas E. Scammell, Alexander G. Bassuk> ;The Journal of Comparative Neurology. 2021 Feb 1
• 13 citations
  Stability of nocturnal wake and sleep stages defines central nervous system disorders of hypersomnolence.
  Kiran Maski, A Colclasure, E Little, E Steinhart, Thomas E. Scammell, William Navidi, Cecilia Diniz Behn> ;Sleep. 2021 Jul 9
• 7 citations
  The Impacts of Age and Sex in a Mouse Model of Childhood Narcolepsy
  Alissa A Coffey, Adam A Joyal, Akihiro Yamanaka, Thomas E. Scammell> ;Frontiers in Neuroscience. 2021 Jan 1
• 19 citations
  Defining Disrupted Nighttime Sleep and Assessing its Diagnostic Utility for Pediatric Narcolepsy Type 1.
  Kiran Maski, Fabio Pizza, Shanshan Liu, E Steinhart, E Little, A Colclasure, Cecilia Diniz Behn, Stefano Vandi, Elena Antelmi, Edie Weller, Thomas E. Scammell, Giusepp...> ;Sleep. 2020 Oct 13
• 6 citations
  COMMENTARY on Lammers et al, Diagnosis of central disorders of hypersomnolence: Challenges in defining central disorders of hypersomnolence
  Kiran Maski, Emmanuel Mignot, Thomas E. Scammell> ;Sleep Medicine Reviews. 2020 May 6
• 3 citations
  Treatment of narcolepsy with natalizumab.
  Thomas E. Scammell, Guo Luo, Priya V. Borker, Lee Sullivan, Kelsey Biddle, Emmanuel Mignot> ;Sleep. 2020 Jul 13
• 26 citations
  Regulation of hippocampal dendritic spines following sleep deprivation
  Barbara Gisabella, Thomas E. Scammell, Sathyajit S. Bandaru, Clifford B. Saper> ;The Journal of Comparative Neurology. 2020 Feb 15
• 23 citations
  A circuit perspective on narcolepsy
  Antoine Roger Adamantidis, Markus H. Schmidt, Matt E. Matt Carter, Denis Burdakov, Christelle Peyron, Thomas E. Scammell> ;Sleep. 2020 May 12
• 16 citations
  Dual orexin receptor antagonists increase sleep and cataplexy in wild type mice.
  Carrie E. Mahoney, Takatoshi Mochizuki, Thomas E. Scammell> ;Sleep. 2020 Jun 15
• 13 citations
  Children with Narcolepsy type 1 have increased T-cell responses to orexins.
  Andrew C. Cogswell, Kiran Maski, Thomas E. Scammell, Dominique Tucker, Zachary S. Orban, Igor J. Koralnik> ;Annals of Clinical and Translational Neurology. 2019 Nov 15
• 18 citations
  Critical Dynamics and Coupling in Bursts of Cortical Rhythms Indicate Non-Homeostatic Mechanism for Sleep-Stage Transitions and Dual Role of VLPO Neurons in Both Sleep...
  Fabrizio Lombardi, Manuel Gómez-Extremera, Pedro Bernaola-Galván, Ramalingam Vetrivelan, Clifford B. Saper, Thomas E. Scammell, Plamen Ch. Ivanov> ;The Journal of Neuroscience. 2020 Jan 2
• 24 citations
  Reassessing the Role of Histaminergic Tuberomammillary Neurons in Arousal Control.
  Anne Venner, Takatoshi Mochizuki, Roberto De Luca, Christelle Anaclet, Thomas E. Scammell, Clifford B. Saper, Elda Arrigoni, Patrick M. Fuller> ;The Journal of Neuroscience. 2019 Nov 6
• 247 citations
  Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment.
  Claudio L. Bassetti, Antoine Roger Adamantidis, Denis Burdakov, Fang Han, Ulf Kallweit, Ramin Khatami, Frits Koning, Brigitte R. Kornum, Gert Jan Lammers, Roland S. Li...> ;Nature Reviews. Neurology. 2019 Jul 19
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Journal Articles

• Damage to histaminergic tuberomammillary neurons and other hypothalamic nuclei with traumatic brain injury  
  Annals of Neurology, 1/1/2015
• Carbachol excites sublaterodorsal nucleus neurons projecting to the spinal cord  
  J Physiol, 1/1/2014
• Optogenetic mediated release of histamine reveals distal and autoregulatory mechanisms for controlling arousal  
  J Neurosci, 1/1/2014
• SCOPRISM: A new algorithm for automatic sleep scoring in mice  
  J. Neurosci Methods, 1/1/2014
• Challenges in diagnosing narcolepsy without cataplexy: a consensus statement  
  Sleep, 1/1/2014
• Narcolepsy as an adverse event following immunization: Case definition and guidelines for data collection, analysis and presentation  
  Vaccine, 1/1/2013
• Amygdala lesions reduce cataplexy in orexin KO mice  
  J Neurosci, 1/1/2013
• Role of the medial prefrontal cortex in cataplexy  
  J Neurosci, 1/1/2013
• Increase of histaminergic tuberomammillary neurons in narcolepsy  
  Annals of Neurology, 1/1/2013
• Control of arousal by the orexin neurons  
  Current Opinion in Neurobiology, 1/1/2013
• Emerging Therapeutics in Sleep  
  Annals of Neurology, 1/1/2013
• Inter-hemispheric oscillations in human sleep  
  PLoS One, 1/1/2012
• Neural circuitry engaged by prostaglandins during the sickness syndrome  
  Nature Neuroscience, 1/1/2012
• Narcolepsy: neural mechanisms of sleepiness and cataplexy  
  Journal of Neuroscience, 1/1/2012
• Seasonal Factors and the Onset of Narcolepsy  
  Journal Watch Neurology, 1/1/2011
• Sodium oxybate is an effective and safe treatment for narcolepsy  
  Sleep Med, 1/1/2009
• Parkinson's disease, sleepiness and hypocretin/orexin  
  Brain, 1/1/2008
• The neurobiology of sleep  
  Neurology Journal Watch, 1/1/2007
• The International Classification of Sleep Disorders  
  American Academy of Sleep Medicine, 1/1/2006
• REM sleep behavior disorder in narcolepsy  
  Neurology Journal Watch, 1/1/2006
• Mistaken diagnosis of psychogenic gait disorder in a man with status cataplecticus ("limp man syndrome")  
  Mov Disord, 1/1/2004
• Behavioral state instability in orexin knockout mice  
  Sleep and Biological Rhythms, 1/1/2004
• Hypocretin deficiency and HLA in narcolepsy  
  Neurology Journal Watch, 1/1/2003
• What is narcolepsy?  
  Neurology Journal Watch, 1/1/2003
• Modafinil: a novel stimulant for the treatment of narcolepsy  
  Exp Opin Invest Drugs, 1/1/1998
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Books/Book Chapters

• Diagnosis and neurobiology of narcolepsy 
  Chapter: Diagnosis and neurobiology of narcolepsy 
  Editors: Rose B, Sanders M, Benca R, Wilson K.UpToDate: Wolters Kluwer2014
• Diagnosis and neurobiology of narcolepsy 
  Chapter: Treatment of narcolepsy 
  Editors: Sanders M, Benca R, Wilson K.UpToDate: Wolters Kluwer2014
• Narcolepsy: Pathophysiology, Diagnosis, and Treatment 
  Chapter: The neural basis of sleepiness in narcoleptic mice 
  Editors: Baumann, CR, Bassetti, CL, Scammell, TE.Springer, NY2011
• Narcolepsy: Pathophysiology, Diagnosis, and Treatment 
  Chapter: Serotonin and narcolepsy 
  Editors: Baumann, CR, Bassetti, CL, Scammell, TE.Springer, NY2011
• Narcolepsy: Pathophysiology, Diagnosis, and Treatment 
  Editors: Baumann, CR, Bassetti, CL, Scammell, TE.Springer, NY2011
• Case Book of Sleep Medicine 
  Chapter: Idiopathic hypersomnia with long sleep time 
  Editors: Winkelman, JW, Henderson, JH, Kotagal, S, Lee-Chiong, TL, Lichstein, KL, Murray, BJ, Schenck, CH.American Academy of Sleep Medicine, Westchester, IL2008
• Narcolepsy and Hypersomnia 
  Chapter: Modafinil: mechanisms of action 
  Editors: Bassetti, C, Mignot, E, Billiard, M.Informa Healthcare, NY2007
• Sleep Disorders and Neurologic Disease 
  Chapter: Secondary narcolepsy 
  Page 117 - 134Editors: Culebras, A.Informa Healthcare, NYEdition 2nd,2007
• Narcolepsy and Hypersomnia 
  Chapter: Treatment guidelines 
  Editors: Bassetti, C, Billiard, M, Mignot, E.Informa Healthcare, NY2007
• The Orexin/Hypocretin System: It's Physiology and Pathophysiology 
  Chapter: Orexin and the hypothalamic control of sleep and waking 
  Editors: Nishino, S, Sakurai, T.Humana Press, Totowa, NJ2006
• Principles of Molecular Medicine 
  Chapter: Narcolepsy and other neurological sleep disorders 
  Page 1153 - 1159Editors: Runge, MS, Paterson, C.Humana Press, Totowa, NJ2006
• Insomnia: Principles and Management 
  Chapter: Hypothalamic pathways and neurotransmitters underlying sleep wake regulation 
  Editors: Szuba, M, Dinges, D, Kloss,.Cambridge University Press, Cambridge, MA2003
• Handbook of Behavioral State Control 
  Chapter: Hypothalamic regulation of sleep 
  Editors: Lydic, R, Baghdoyan, HA.CRC Press, NY1998
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Abstracts/Posters

• GABA and glutamatergic projections from the basal forebrain to the MCH neurons
  Sleep, 1/1/2013
• Neural circuitry of cataplexy: projection targets of GABA cells subpopulations in the central amygdala
  Sleep, 1/1/2013
• Basal forebrain efferents to the orexin neurons
  Sleep, 1/1/2013

Lectures

• Narcolepsy: Neurobiology and Neuropathology 
  University of Pennsylvania, Philadelphia, PA - 1/1/2014
• Treatment of Narcolepsy 
  Minneapolis, MN - 1/1/2014
• Neurobiology of Cataplexy 
  Minneapolis, MN - 1/1/2014
• Year in Review: Narcolepsy 
  Minneapolis, MN - 1/1/2014
• Interaction of Orexin and Histamine Systems 
  Tallinn, Estonia - 1/1/2014
• Rodent Models for Understanding Sleep 
  Children's Hospital Boston - 1/1/2012
• Rodent Models for Understanding Narcolepsy 
  Children's Hospital Boston - 1/1/2012
• Narcolepsy: Neurobiology of sleepiness and cataplexy 
  1/1/2012
• Narcolepsy: Clinical Features, Diagnosis, and Pathophysiology 
  Boston, MA - 1/1/2012
• Molecular Dissection of Narcolepsy Signs and Symptoms 
  Boston, MA - 1/1/2012
• Regulation of Wakefulness and Sleep by Orexin/Hypocretin 
  Stanford University, Stanford, CA - 1/1/2011
• Remaining Mysteries: Etiology & Genetics 
  Budapest, Hungary - 1/1/2011
• New insights into the causes of sleepiness and cataplexy 
  University of Zurich, Zurich, Switzerland - 1/1/2011
• Neurobiology of Orexin Antagonists 
  Kyoto, Japan - 1/1/2011
• Afferent and Efferent Control of the Orexin System 
  Kyoto, Japan - 1/1/2011
• What sleepy mice can teach us about sleepy people 
  1/1/2010
• Neurobiology of Narcolepsy 
  Center for Brain Science, Harvard College - 1/1/2010
• Narcolepsy: What sleepy mice can teach us about sleepy people 
  Seattle, WA - 1/1/2009
• Orexins and the Neural Control of Sleep and Wakefulness 
  Basel, Switzerland - 1/1/2009
• The Neural Basis of Sleepiness in Narcoleptic Mice 
  Ascona, Switzerland - 1/1/2009
• Orexin receptor-2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice 
  Osaka, Japan - 1/1/2009
• The Neurobiology of Narcolepsy 
  Harvard Medical School - 1/1/2008
• Modeling the Dynamics of Sleep using State Space Analysis 
  Boston, MA - 1/1/2008
• Sleep.Wake Circuits and How They are Modulated by Medications 
  University of Utah, Salt Lake City, UT - 1/1/2008
• Hypothalamic Control of Sleep and Circadian Rhythms 
  Leiden University Medical Center, Leiden, Netherlands - 1/1/2008
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Other

• Narcolepsy 
  Harvard Medical School
  1/1/2014
• Commentary on narcolepsy and orexin 
  The Boston Globe
  1/1/2009
• The Sleepy Student 
  Human Nervous System and Behavior course
  1/1/2009
• The regulation of sleep & circadian rhythm 
  Monograph, National Sleep Foundation
  1/1/2004
• Narcolepsy and Other Causes of Sleepiness 
  American College of Physicians
  1/1/2003
• Living without sleep 
  The Connection, NPR
  1/1/2002
• Commentary on modafinil 
  Good Morning America
  1/1/2001
• Clinical features and diagnosis of narcolepsy 
  Scammell TE
  http://www.uptodate.com/contents/clinical-features-and-diagnosis-of-narcolepsy
  UpToDate, Wolters Kluwer Health - 2013-03-15
• Treatment of narcolepsy 
  Scammell TE
  http://www.uptodate.com/contents/treatment-of-narcolepsy
  UpToDate, Wolters Kluwer Health - 2013-01-21
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