RyanDavidRobertsMD

PubMed

• Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization.
  Camille A McAloney, Rawan Makkawi, Yogesh Budhathoki, Matthew V Cannon, Emily M Franz, Amy C Gross, Maren Cam, Tatyana A Vetter, Rebekka Duhen, Alexander E Davies, Rya...> ;Cellular Oncology. 2024 Feb 1
• 3 citations
  Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization.
  Sanjana Rajan, Emily M Franz, Camille A McAloney, Tatyana A Vetter, Maren Cam, Amy C Gross, Cenny Taslim, Meng Wang, Matthew V Cannon, Alexander Oles, Ryan D Roberts> ;BMC Biology. 2023 Apr 27
• Redundant Signaling as the Predominant Mechanism for Resistance to Antibodies Targeting the Type-I Insulin-Like Growth Factor Receptor in Cells Derived from Childhood ...
  Terry J Shackleford, Seethalakshmi Hariharan, Angelina V Vaseva, Karina Alagoa, Maricruz Espinoza, Hemant K Bid, Fuyang Li, Haihong Zhong, Doris A Phelps, Ryan D Rober...> ;Molecular Cancer Therapeutics. 2023 Apr 3
• 3 citations
  Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition.
  Upendra Kumar Soni, Yuhua Wang, Ram Naresh Pandey, Ryan Roberts, Joseph G Pressey, Rashmi S Hegde> ;Clinical Cancer Research. 2023 Jan 17
• 17 citations
  An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma.
  Shulman, D., Whittle, S., Surdez, D., Bailey, K., de Álava, E., Yustein, J., Shlien, A., Hayashi, M., Bishop, A., Crompton, B., DuBois, S., Shukla, N., Leavey, P., Les...> ;NPJ Precision Oncology. 2022 Sep 17
• 7 citations
  Lurbinectedin Inhibits the EWS-WT1 Transcription Factor in Desmoplastic Small Round Cell Tumor.
  Jenna M Gedminas, Rebecca Kaufman, Elissa A Boguslawski, Amy C Gross, Marie Adams, Ian Beddows, Susan M Kitchen-Goosen, Ryan D Roberts, Patrick J Grohar> ;Molecular Cancer Therapeutics. 2022 Aug 2
• 3 citations
  EGFR internal tandem duplications in fusion-negative congenital and neonatal spindle cell tumors.
  Selene C Koo, Kathleen M Schieffer, Kristy Lee, Ajay Gupta, Ruthann B Pfau, Matthew R Avenarius, Eileen Stonerock, Stephanie LaHaye, James Fitch, Bhuvana A Setty, Ryan...> ;Genes, Chromosomes & Cancer. 2023 Jan 1
• Clinical outcomes and efficacy of stereotactic body radiation therapy in children, adolescents, and young adults with metastatic solid tumors.
  Sujith Baliga, Jennifer Matsui, Brett Klamer, Ashley Cetnar, Ashlee Ewing, Catherine Cadieux, Ajay Gupta, Bhuvana A Setty, Ryan D Roberts, Randal S Olshefski, Timothy ...> ;The British Journal of Radiology. 2022 May 1
• 13 citations
  Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma.
  Safiya Khurshid, Matias Montes, Daniel F Comiskey Jr, Brianne Shane, Eleftheria Matsa, Francesca Jung, Chelsea Brown, Hemant Kumar Bid, Ruoning Wang, Peter J Houghton,...> ;NPJ Precision Oncology. 2022 Jan 11
• 5 citations
  Targeted Therapy in a Young Adult With a Novel Epithelioid Tumor Driven by a PRRC2B-ALK Fusion.
  Ajay Gupta, Huifei Liu, Kathleen M Schieffer, Selene C Koo, Catherine E. Cottrell, Elaine R. Mardis, Ryan D. Roberts, Nicholas D. Yeager> ;Journal of the National Comprehensive Cancer Network. 2021 Oct 15
• 9 citations
  Genetic Characterization of Pediatric Sarcomas by Targeted RNA Sequencing.
  Matthew R. Avenarius, Cecelia R. Miller, Michael Arnold, Selene C. Koo, Ryan D. Roberts, Martin Hobby, Thomas Grossman, Yvonne Moyer, Richard K. Wilson, Elaine R. Mard...> ;The Journal of Molecular Diagnostics. 2020 Aug 1
• 34 citations
  GD2-directed CAR-T cells in combination with HGF-targeted neutralizing antibody (AMG102) prevent primary tumor growth and metastasis in Ewing sarcoma.
  Manish Charan, Piyush Dravid, Maren Cam, Anthony N. Audino, Amy C. Gross, Michael Arnold, Ryan D. Roberts, Timothy P. Cripe, Alexander Pertsemlidis, Peter J. Houghton,...> ;International Journal of Cancer. 2020 Jun 1
• 25 citations
  An evolutionary framework for treating pediatric sarcomas
  Damon R. Reed, Jonathan Metts, Mariyah Pressley, Brooke L. Fridley, Masanori Hayashi, Michael S. Isakoff, David M. Loeb, Rikesh J Makanji, Ryan D. Roberts, Matteo Truc...> ;Cancer. 2020 Jun 1
• 8 citations
  Targeting protein translation by rocaglamide and didesmethylrocaglamide to treat MPNST and other sarcomas
  Long-Sheng Chang, Janet L. Oblinger, Sarah S. Burns, Jie Huang, Lawrence W. Anderson, Melinda G. Hollingshead, Rulong Shen, Li Pan, Garima Agarwal, Yulin Ren, Ryan D. ...> ;Molecular Cancer Therapeutics. 2020 Mar 1
• 22 citations
  Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metast...
  Manish Charan, Piyush Dravid, Maren Cam, Bhuvana A. Setty, Ryan D. Roberts, Peter J. Houghton, Hakan Cam> ;Oncotarget. 2020 Feb 4
• 53 citations
  Understanding and Modeling Metastasis Biology to Improve Therapeutic Strategies for Combating Osteosarcoma Progression
  Timothy M. Fan, Ryan D. Roberts, Michael M. Lizardo> ;Frontiers in Oncology. 2020 Jan 31
• 2 citations
  Targetable Intercellular Signaling Pathways Facilitate Lung Colonization in Osteosarcoma
  James Brandon Reinecke, Ryan D. Roberts> ;Advances in Experimental Medicine and Biology. 2020 Jan 1
• 18 citations
  Immunotherapeutic Challenges for Pediatric Cancers.
  Brian Hutzen, Mohammed G. Ghonime, Joel Lee, Elaine R. Mardis, Ruoning Wang, Dean A. Lee, Mitchell S. Cairo, Ryan D. Roberts, Timothy P. Cripe, Kevin A. Cassady> ;Molecular Therapy Oncolytics. 2019 Dec 20
• 74 citations
  Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group
  Ryan D. Roberts, Michael M. Lizardo, Damon R. Reed, Pooja Hingorani, Jason Glover, Wendy Allen-Rhoades, Timothy M. Fan, Chand Khanna, E. Alejandro Sweet-Cordero, Thoma...> ;Cancer. 2019 Oct 15
• 3 citations
  A Rare Case of an Intracardiac Myoepithelial Carcinoma in an Infant.
  Priyal Patel, Ryan D. Roberts, Jason Cole, Melissa Stalling, Kathleen Nicol, Kan Hor, Jessica Bowman, Bhuvana A. Setty> ;Journal of Pediatric Hematology/oncology. 2019 May 1
• 2 citations
  Is Estrogen the Answer for Osteosarcoma
  Ryan D. Roberts> ;Cancer Research. 2019 Mar 15
• 54 citations
  IL-6 and CXCL8 mediate osteosarcoma-lung interactions critical to metastasis
  Amy C. Gross, Hakan Cam, Doris A. Phelps, Amanda J. Saraf, Hemant K. Bid, Maren Cam, Cheryl A. London, Sarah Winget, Michael Arnold, Laura Brandolini, Xiaokui Mo, John...> ;JCI Insight. 2018 Aug 23
• 149 citations
  Osteosarcoma: Accelerating Progress Makes for a Hopeful Future.
  Amanda J. Saraf, Joelle M. Fenger, Ryan D. Roberts> ;Frontiers in Oncology. 2018 Jan 26
• 14 citations
  Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma.
  Peter Y. Yu, Heather L. Gardner, Ryan D. Roberts, Hakan Cam, Seethalakshmi Hariharan, Ling Ren, Amy K. LeBlanc, Hui Xiao, Jiayuh Lin, Denis C. Guttridge, Xiaokui Mo, C...> ;Plos One. 2017 Jul 27
• 24 citations
  Immune profiling of NF1-associated tumors reveals histologic subtype distinctions and heterogeneity: implications for immunotherapy.
  Kellie B. Haworth, Michael Arnold, Christopher R. Pierson, Kwangmin Choi, Nicholas D. Yeager, Nancy Ratner, Ryan D. Roberts, Jonathan L. Finlay, Timothy P. Cripe> ;Oncotarget. 2017 May 30
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Journal Articles

• MiR-9 is overexpressed in spontaneous canine osteosarcoma and promotes a metastatic phenotype including invasion and migration in osteoblasts and osteosarcoma cell lines  
  Fenger JM, Roberts RD, Iwenofu OH, Bear MD, Zhang X, Couto JI, Modiano JF, Kisseberth WC, London CA, BMC Cancer, 1/1/2016
• Characterization of MHC Class I and beta-2-Microglobulin Expression in Pediatric Solid Malignancies to Guide Selection of Immune-Based Therapeutic Trials  
  Haworth KB, Arnold MA, Pierson CR, Leddon JL, Kurmashev DK, Swain HM, Hutzen BJ, Roberts RD, Cripe TP, Pediatr Blood Cancer, 1/1/2016
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  Cam M, Gardner HL, Roberts RD, Fenger JM, Guttridge DC, London CA, Cam H, Oncotarget, 1/1/2016
• (Delta)Np63 promotes Childhood Cancers Neuroblastoma and Osteosarcoma by regulating tumor angiogenesis  
  Roberts RD and Bid HK (equal authorship), Cam M, Audino A, Kurmasheva RT, Lin J, Houghton PJ, and Cam H, Cancer Res, 1/1/2014
• RAC1: An Emerging Therapeutic Option for Targeting Cancer Angiogenesis and Metastasis  
  Roberts RD and Bid HK (equal authorship), Manchanda PK, and Houghton PJ, Mol Cancer Ther, 1/1/2013
• Modeling the inhibition of breast cancer growth by GM-CSF  
  Szomolay B, Eubank TD, Roberts RD, Marsh CB, Friedman A, J of Theor Biol, 1/1/2012
• GM-CSF inhibits breast cancer growth and metastasis by invoking an anti-angiogenic program in tumor-educated macrophages  
  Roberts RD and Eubank TD (equal authorship), Khan M, Curry JM, Nuovo GJ, Kuppusamy P, and Marsh CB, Cancer Res, 1/1/2009
• M-CSF signals through the MAPK/ERK pathway via Sp1 to induce VEGF production and induces angiogenesis in vivo  
  Curry JM, Eubank TD, Roberts RD, Wang Y, Pore N, Maity A, and Marsh CB, PLoS ONE, 1/1/2008
• Determination of Body Composition in Children with Cerebral Palsy: BIA and Anthropometry versus DEXA  
  Liu LF, Roberts R, Moyer-Mileur LJ, Samson-Fang L, J Am Diet Assoc, 1/1/2005
• GM-CSF Induces Expression of Soluble VEGF Receptor-1 from Human Monocytes and Inhibits Angiogenesis in Mice  
  Eubank TD, Roberts R, Galloway M, Cohn DE, and Marsh CB, Immunity, 1/1/2004
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Books/Book Chapters

• Malignant Pediatric Bone Tumors - Treatment & Management. 
  Chapter: Chemotherapy Regimens for Patients with Newly Diagnosed Malignant Bone Tumors. 
  Roberts, RD, Wedekind, MF & Setty, BAEditors: T. P. Cripe & N. D. Yeager.Springer International Publishing2015

Abstracts/Posters

• Manipulating mechanisms of lung tropism to prevent osteosarcoma metastasis.
  Ryan D. Roberts; Amy C. Gross; Hemant K. Bid; Doris Phelps; et. al, 8th annual meeting of the Cancer Molecular Therapeutics Research Association, Boston, MA, 1/1/2015
• Targeting mediators of lung tropism to prevent osteosarcoma metastasis.
  Ryan D. Roberts, Hemant K. Bid, Doris Phelps, Brett W. Hendrickson, Hakan Cam, Peter J. Houghton, 7th annual meeting of the Cancer Molecular Therapeutics Research Association, Asilomar, CA, 1/1/2014
• Genes that mediate lung tropism in osteosarcoma.
  Ryan D. Roberts, Doris A. Phelps, Hemant K. Bid, Hakan Cam, Brett W. Hendrickson, Peter J. Houghton, 6th annual meeting of the Cancer Molecular Therapeutics Research Association, Boulder, CO, 1/1/2013
• Autocrine and paracrine IL-6 and IL-8 drive osteosarcoma metastasis.
  Ryan D. Roberts; Hemant K. Bid; Doris Phelps; Brett W. Hendrickson; Hakan Cam; Peter J. Houghton, AACR special meeting, Pediatric Cancer at the Crossroads: Translating Discovery Into Improved Outcomes, San Diego, CA, 1/1/2013
• Comparison of cytokine profiles between normal and ischemic wound tissue.
  Tim Eubank, Ryan Roberts, Valerie Bergdall, Sabyasachi Biswas, Chandan Sen, and Clay Marsh, 18th Annual Meeting of the Wound Healing Society, San Diego, CA, 1/1/2008
• Evidence for heterogeneity and pliability of tumor-educated macrophages.
  Ryan Roberts, Tim Eubank, Randall Evans, Mahmood Khan, Jennifer Curry, Nicholas Sullivan, Brett Hall, Gerard Nuovo, Periannan Kuppusamy, and Clay Marsh, 5th Era of Hope Meeting, Snowbird, UT, 2008; Baltimore, MD, 2008, 1/1/2008
• GM-CSF Inhibits Breast Cancer Growth and Metastases in Mice and Induces Hypoxia in the Tumor Proper.
  Ryan D. Roberts, Timothy D. Eubank, Jennifer Curry, Clay B. Marsh, Keystone Symposium on Tumor-Host Interactions, Keystone, CO, 1/1/2007
• Distal and mid-shaft tibia bone mass assessment using peripheral quantitative computed tomography in healthy children and adolescents.
  Moyer-Mileur LJ, Roberts R and Ball SD, American Society for Bone and Mineral Research, Phoenix, AZ, 1/1/2001
• Obese children have greater bone mass and strength in relation to muscle area but not bone weight.
  Moyer-Mileur LJ, Roberts R and Ball SD, Pediatric Bone and Mineral Working Group, American Society for Bone and Mineral Research, Phoenix, AZ, 1/1/2001
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Lectures

• Osteosarcoma: exploiting tumor-lung interactions to prevent and treat metastatic disease 
  Columbus, OH - 1/1/2016
• Combined Targeting of IL6 and IL8 Axes Prevents Osteosarcoma Lung Metastasis 
  Lisbon, Portugal - 1/1/2016
• Manipulating mechanisms of lung tropism to prevent osteosarcoma metastasis 
  Jackson Hole, WY - 1/1/2015
• IL-6 and IL-8 mediate osteosarcoma lung tropism and metastasis 
  Salt Lake City, UT - 1/1/2015
• Identifying and manipulating mechanisms of lung tropism to prevent metastasis in osteosarcoma 
  Dallas, TX - 1/1/2014
• Selective Augmentation of a Particular Subset of Monocyte/Macrophages Worsens Breast Cancer Progression 
  Keystone, CO - 1/1/2008
• GM-CSF Inhibits Breast Cancer Growth and Metastases in Mice by Blocking Angiogenesis via Macrophage Production of sVEGFR-1 
  Keystone, CO - 1/1/2007
• An Integrated Curriculum for an Integrated Career 
  Keystone, CO - 1/1/2007
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Other

• The Canine-Kid Connection 
  Roberts R, Coalition Against Childhood Cancer All-Member Webinar
  http://cac2.org
  1/1/2016