ShyamVaradarajuluMD

Gastroenterology • Orlando, FL

Advanced Endoscopic Interventional

President, Digestive Health Institute, Orlando Health System

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Office
1414 Kuhl Avenue.
Orlando, FL 32806
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Summary

I am an interventional endoscopist with particular expertise in EUS and ERCP. I direct the Orlando Health's Digestive Health Institute a multidisciplinary group that strives to practice academic medicine in a private setting with core mission values being high quality clinical care, research and education.

Shyam Varadarajulu

https://www.youtube.com/channel/UCjYmt_RTyl1smmF9_pAWEIg

Education & Training

Medical University of South CarolinaAdvanced Endoscopy Fellowship, 2001 - 2003
University of ConnecticutFellowship, Gastroenterology, 1998 - 2001
Rochester Regional Health/Unity Hospital (Rochester)Residency, Internal Medicine, 1995 - 1998
Madras Medical CollegeClass of 1993

Certifications & Licensure

FL State Medical License 2011 - 2026
AL State Medical License Active through 2018
SC State Medical License 2001 - 2009
CT State Medical License 1997 - 2001
American Board of Internal Medicine Gastroenterology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014

Clinical Trials

Endoscopic Ultrasound (EUS) Guided-Celiac Plexus Neurolysis (CPN) in Unresectable Pancreatic Cancer Start of enrollment: 2009 Jun 01
Completed
Not Applicable
Comparison of Metal and Plastic Stents for Preoperative Biliary Decompression Start of enrollment: 2010 Jul 01
Completed
Not Applicable
22G FNA Needle vs. 22G ProCore Needle Start of enrollment: 2011 Jul 01
Completed
Not Applicable
Standard Versus Fanning Techniques for Endoscopic Ultrasound-Fine Needle Aspiration (EUS-FNA) Start of enrollment: 2011 Sep 01
Completed
Not Applicable
Trial Comparing Metal Versus Plastic Stents for Preoperative Biliary Decompression Start of enrollment: 2012 Aug 22
Completed
Not Applicable
Trial Comparing 19 and 25-gauge EUS-FNA Needles Start of enrollment: 2012 Aug 01
Completed
Not Applicable
Evaluating the Number of Passes Required for Diagnostic Cell Block During EUS-FNA of Solid Pancreatic Mass Lesions Start of enrollment: 2013 Feb 01
Completed
Not Applicable
Endoscopic Ultrasound (EUS) Processor Comparison Start of enrollment: 2013 Mar 01
Withdrawn
Trial Comparing 19 and 25G Needles for Fine Needle Aspiration (FNA) of Solid Pancreatic Mass Lesions Greater Than 35mm Start of enrollment: 2013 Feb 01
Completed
Not Applicable
Comparison of On-Site Versus Off-Site Evaluation of Cholangioscopy-Guided Biopsies of the Bile Duct Start of enrollment: 2013 Feb 01
Completed
Not Applicable
Evaluation of Injection Techniques in Celiac Plexus Neurolysis Start of enrollment: 2013 Aug 01
Completed
Not Applicable
Minimally Invasive Surgery vs. Endoscopy Randomized (MISER) Trial for Necrotizing Pancreatitis Start of enrollment: 2014 Apr 01
Completed
Not Applicable
Registry of Pancreatic Fluid Collections and Pancreatic Cysts Start of enrollment: 2015 Feb 01
Withdrawn
Endoscopic Ultrasound and Endoscopic Retrograde Cholangiopancreatography for Malignant Distal Biliary Obstruction Start of enrollment: 2016 Sep 01
Completed
Not Applicable
Pancreatic Duct Stent for Acute Necrotizing Pancreatitis Start of enrollment: 2016 Aug 04
Completed
Not Applicable
Trial Comparing EUS-guided Radiofrequency Ablation vs. EUS-guided Celiac Plexus Neurolysis Start of enrollment: 2017 Apr 24
Completed
Not Applicable
Radiation Exposure Assessment in Fluoroscopy Start of enrollment: 2019 May 06
Completed
Endoscopic Ultrasound vs Percutaneous Route for Liver Biopsy Start of enrollment: 2019 Jul 25
Completed
Not Applicable
The Development and Evaluation of a Novel Duodenoscope Assessment Tool Start of enrollment: 2019 May 20
Completed
Fine Needle Biopsy of Solid Pancreatic Mass Lesions Start of enrollment: 2019 Sep 09
Recruiting
Not Applicable
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Publications & Presentations

PubMed

EUS-guided gallbladder drainage in acute cholecystitis: response to letter to the editor.
Ji Young Bang, Juan Pablo Arnoletti, Andrew Wagner, Shyam Varadarajulu> ;Gut. 2024 Apr 12
Clinical and Economic Implications of Interventions in Pancreatic Fluid Collections: An Assessment From a National Claims Database.
Michael J Cangelosi, Geri R Cramer, Kevin Kuipers, Stacey Reimer, Ann K Roy, Shyam Varadarajulu> ;Pancreas. 2024 Apr 10
Rise In First-Time ERCP For Benign Indications >1 Year After Cholecystectomy Is Associated With Worse Outcomes.
Douglas E Schaubel, B Joseph Elmunzer, Gregory A Coté, Nikhil R Thiruvengadam, Monica Saumoy, Peter B Cotton, Martin L Freeman, Shyam Varadarajulu, Michael L Kochman> ;Clinical Gastroenterology and Hepatology. 2024 Apr 8
The DESTIN trial: to step up or not? - Authors' reply.
Ji Young Bang, Shyam Varadarajulu> ;The Lancet. Gastroenterology & Hepatology. 2024 Apr 1
Reply to Saito et al.
Shyam Varadarajulu> ;Endoscopy. 2024 Apr 1
1 citations
Indomethacin with or without prophylactic pancreatic stent placement to prevent pancreatitis after ERCP: a randomised non-inferiority trial.
Elmunzer, B., Foster, L., Serrano, J., Coté, G., Edmundowicz, S., Wani, S., Shah, R., Bang, J., Varadarajulu, S., Singh, V., Khashab, M., Kwon, R., Scheiman, J., Willi...> ;Lancet. 2024 Feb 3
Does endoprosthesis design impact bleeding risk when using lumen-apposing metal stents for drainage of pancreatic fluid collections?
Shyam Varadarajulu> ;Endoscopy. 2024 Apr 1
2 citations
EUS-guided gallbladder drainage in acute cholecystitis: long-term problems with surgical approach.
Bang, J., Arnoletti, J., Wagner, A., Varadarajulu, S.> ;Gut. 2024 Feb 23
7 citations
Upfront endoscopic necrosectomy or step-up endoscopic approach for infected necrotising pancreatitis (DESTIN): a single-blinded, multicentre, randomised trial.
Ji Young Bang, Sundeep Lakhtakia, Shyam Thakkar, James L Buxbaum, Irving Waxman, Bryce Sutton, Sana F Memon, Shailendra Singh, Jahangeer Basha, Ajay Singh, Udayakumar ...> ;The Lancet. Gastroenterology & Hepatology. 2024 Jan 1
Orlando Protocol for single session ductal clearance of common bile duct stones at endosopic retrograde cholangiopancreatography.
Ji Young Bang, C Mel Wilcox, Udayakumar Navaneethan, Robert Hawes, Shyam Varadarajulu> ;Digestive Endoscopy. 2023 Nov 12
Endoscopic Ultrasound Guided Walled-off Necrosis Drainage.
Philippe Willems, Shyam Varadarajulu> ;Gastrointestinal Endoscopy Clinics of North America. 2023 Oct 1
7 citations
Treatment of walled-off necrosis using lumen-apposing metal stents versus plastic stents: a systematic review and meta-analysis of data from randomized trials.
Ji Young Bang, Charles Melbern Wilcox, Udayakumar Navaneethan, Robert Holbrook Hawes, Shyam Varadarajulu> ;Endoscopy. 2024 Mar 1
Primary leiomyosarcoma of the pancreas with metastasis to the spleen.
Philippe Willems, Konrad Krall, Shyam Varadarajulu> ;Videogie. 2023 Jul 1
Pushing the EDGE: using the slim linear US endoscope for fine-needle biopsy during an EUS-directed transgastric ERCP procedure.
Philippe Willems, Ji Young Bang, Shyam Varadarajulu> ;Gastrointestinal Endoscopy. 2023 Oct 1
6 citations
Impact of endoprosthesis type on inflammatory response in patients undergoing endoscopic drainage of pancreatic fluid collections.
Ji Young Bang, Charles Mel Wilcox, Udayakumar Navaneethan, Robert Hawes, Shyam Varadarajulu> ;Digestive Endoscopy. 2024 Feb 1
2 citations
Standardisation of EUS-guided FNB technique for molecular profiling in pancreatic cancer: results of a randomised trial.
Ji Young Bang, Nirag Jhala, Anjali Seth, Konrad Krall, Udayakumar Navaneethan, Robert Hawes, Charles Melbern Wilcox, Shyam Varadarajulu> ;Gut. 2023 Jul 1
2 citations
Mechanical Lithotripsy for Large Common Bile Duct Stones: Out of Practice or Just Out of Fashion?
Philippe Willems, Robert H Hawes, Shyam Varadarajulu> ;Clinical Gastroenterology and Hepatology. 2023 Nov 1
Response to the letter to the editor.
Ji Young Bang, Robert Hawes, Shyam Varadarajulu> ;Gut. 2022 Apr 1
Treatment of Walled-off Necrosis – Outcomes are Best When Endoscopy and Percutaneous Interventions are Complimentary, Not Exclusive
Ji Young Bang, Shyam Varadarajulu> ;Clinical Endoscopy. 2021 Nov 30
22-gauge fine-needle biopsy needles: Primary workhorse for endoscopic ultrasound-guided tissue acquisition
Ji Young Bang, Shyam Varadarajulu> ;Digestive Endoscopy. 2021 Nov 29
8 citations
Endoscopic biliary drainage for malignant distal biliary obstruction: which is better - ERCP or EUS?
Ji Young Bang, Robert H. Hawes, Shyam Varadarajulu> ;Digestive Endoscopy. 2021 Nov 8
19 citations
Validation of the Orlando Protocol for endoscopic management of pancreatic fluid collections in the era of lumen-apposing metal stents.
Ji Young Bang, C. Mel Wilcox, Juan Pablo Arnoletti, Shajan Peter, John D. Christein, Udayakumar Navaneethan, Robert H. Hawes, Shyam Varadarajulu> ;Digestive Endoscopy. 2021 Jul 31
2 citations
Quality of reporting in endoscopic ultrasound: Results of an international multicenter survey (the QUOREUS study).
Pietro Fusaroli, Mohamad A. Eloubeidi, Claudio Calvanese, Christoph F. Dietrich, Christian Jenssen, Adrian Saftoiu, Claudio De Angelis, Shyam Varadarajulu, Bertrand Na...> ;Endoscopy International Open. 2021 Jun 21
7 citations
Single-use duodenoscopes: where are we and where are we going?
Shajan Peter, Ji Young Bang, Shyam Varadarajulu> ;Current Opinion in Gastroenterology. 2021 May 19
1 citations
Single-operator cholangioscopy-guided biopsy of indeterminate bile duct strictures: Work in progress.
Ji Young Bang, Konrad Krall, Shyam Varadarajulu> ;Digestive Endoscopy. 2021 Apr 7
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Other

Porcelain gallbladder
Varadarajulu S, Zakko SF
http://www.uptodate.com/contents/porcelain-gallbladder
UpToDate, Wolters Kluwer Health - 2012-11-09
Xanthogranulomatous cholecystitis
Varadarajulu S, Zakko SF
http://www.uptodate.com/contents/xanthogranulomatous-cholecystitis
UpToDate, Wolters Kluwer Health - 2012-11-09

Authored Content

Single-Operator Cholangioscopy-Guided Lithotripsy vs. Large Balloon Sphincteroplasty in Management of Difficult Bile Duct StonesFebruary 2020
Stent Placement by EUS or ERCP for Primary Biliary Decompression in Pancreatic Cancer: A Randomized Trial (With Videos)March 2018
Stent Placement by EUS or ERCP for Primary Biliary Decompression in Pancreatic Cancer: A Randomized Trial (With Videos)March 2018
Randomized Trial Comparing the Franseen and Fork-Tip Needles for EUS-Guided Fine-Needle Biopsy of Solid Pancreatic Mass LesionsJanuary 2018
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Press Mentions

Orlando Health Digestive Health Institute to Establish Liver Center, Begin Groundwork for Solid Organ Transplant ProgramApril 14th, 2022
U.S. FDA Grants Breakthrough Device Designation for Innovative EndoSound Vision Ultrasound SystemSeptember 1st, 2021
4th International Conference on Gastroenterology and Therapeutic Gastrointestinal Endoscopy OrganisedOctober 28th, 2018
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Grant Support

Pancreas SporeNIDDK2006–2012

Committees

Councilor, Pancreas Section, AGA 2019 - 2021
ACG, Pancreatitis Task Force 2018 - 2018
Technology Committee, ASGE 2009 - 2012
ASGE, Postgraduate Education 2006 - 2009

Research History

Medical Director of EndoscopyI have been Principal Investigator of 20 randomized trials in interventional endoscopy that have been successfully concluded and results published. I have published more than 300 peer-reviewed manuscripts in peer-reviewed journals. Research remains a priority at Orlando Health Digestive Institute.2003 - Present