StephenAaronLiebhaberMD

PubMed

• 3 citations
  Dynamic changes in RNA–protein interactions and RNA secondary structure in mammalian erythropoiesis
  Mengge Shan, Xinjun Ji, Kevin A. Janssen, Ian M. Silverman, Jesse Humenik, Ben A. Garcia, Stephen A. Liebhaber, Brian D. Gregory> ;Life Science Alliance. 2021 Jul 27
• 4 citations
  RNA-binding proteins PCBP1 and PCBP2 are critical determinants of murine erythropoiesis
  Xinjun Ji, Anupama Jha, Jesse Humenik, Louis R. Ghanem, Andrew Kromer, Christopher Duncan-Lewis, Elizabeth A. Traxler, Mitchell J. Weiss, Yoseph Barash, Stephen A. Lie...> ;Molecular and Cellular Biology. 2021 Jun 28
• 2 citations
  The Transcription Factor NR4A2 Plays an Essential Role in Driving Prolactin Expression in Female Pituitary Lactotropes.
  Michael T. Peel, Yugong Ho, Stephen A. Liebhaber> ;Endocrinology. 2020 May 1
• 36 citations
  Single-cell transcriptomic analysis of adult mouse pituitary reveals sexual dimorphism and physiologic demand-induced cellular plasticity
  Yugong Ho, Peng Hu, Michael T. Peel, Sixing Chen, Pablo G. Camara, Douglas J. Epstein, Hao Wu, Stephen A. Liebhaber> ;Protein & Cell. 2020 Mar 19
• 3 citations
  A cytosine-rich splice regulatory determinant enforces functional processing of the human α-globin gene transcript.
  Xinjun Ji, Jesse Humenik, Stephen A. Liebhaber> ;Blood. 2019 May 23
• 8 citations
  Transcriptome Analyses of Female Somatotropes and Lactotropes Reveal Novel Regulators of Cell Identity in the Pituitary.
  Michael T. Peel, Yugong Ho, Stephen A. Liebhaber> ;Endocrinology. 2018 Dec 1
• 8 citations
  Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript.
  Louis R. Ghanem, Andrew Kromer, Ian M. Silverman, Xinjun Ji, Matthew R. Gazzara, Nhu Nguyen, Gabrielle Aguilar, Massimo Martinelli, Yoseph Barash, Stephen A. Liebhaber> ;Molecular and Cellular Biology. 2018 Jul 30
• 96 citations
  Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells.
  Jeremy D. Grevet, Xianjiang Lan, Nicole Hamagami, Christopher R. Edwards, Laavanya Sankaranarayanan, Xinjun Ji, Saurabh K. Bhardwaj, Carolyne J. Face, David Posocco, O...> ;Science. 2018 Jul 20
• 14 citations
  PolyC-binding proteins enhance expression of the CDK2 cell cycle regulatory protein via alternative splicing.
  Xinjun Ji, Jesse Humenik, Daphne Yang, Stephen A. Liebhaber> ;Nucleic Acids Research. 2018 Feb 28
• 11 citations
  Long-range looping of a locus control region drives tissue-specific chromatin packing within a multigene cluster
  Yu-Cheng Tsai, Nancy E. Cooke, Stephen A. Liebhaber> ;Nucleic Acids Research. 2016 Jun 2
• 28 citations
  αCP binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome
  Xinjun Ji, Juw Won Park, Emad Bahrami-Samani, Lan Lin, Christopher Duncan-Lewis, Gordon Pherribo, Yi Xing, Stephen A. Liebhaber> ;Nucleic Acids Research. 2016 Mar 18
• 27 citations
  Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD
  Marie-Laure Sobrier, Yu-Cheng Tsai, Christelle Perez, Bruno Leheup, Tahar Bouceba, Philippe Duquesnoy, Bruno Copin, Daria Sizova, Alfredo Penzo, Ben Z. Stanger, Nancy ...> ;Human Molecular Genetics. 2016 Feb 1
• 39 citations
  Cytoplasmic poly(A) binding protein-1 binds to genomically encoded sequences within mammalian mRNAs
  Hemant K. Kini, Ian M. Silverman, Xinjun Ji, Brian D. Gregory, Stephen A. Liebhaber> ;RNA. 2016 Jan 1
• 46 citations
  The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development
  Louis R. Ghanem, Andrew Kromer, Ian M. Silverman, Priya Chatterji, Elizabeth A. Traxler, Alfredo I. Penzo-Méndez, Mitchell J. Weiss, Ben Z. Stanger, Stephen A. Liebhaber> ;Molecular and Cellular Biology. 2015 Nov 2
• 26 citations
  Resistance of mRNAs with AUG-proximal nonsense mutations to nonsense-mediated decay reflects variables of mRNA structure and translational activity
  Francisco J.C. Pereira, Alexandre Teixeira, Jian Kong, Cristina Barbosa, Ana Luísa Silva, Ana Marques-Ramos, Stephen A. Liebhaber, Luísa Romão> ;Nucleic Acids Research. 2015 Jul 27
• 5 citations
  An Autoregulatory Pathway Establishes the Definitive Chromatin Conformation at the Pit-1 Locus
  Yugong Ho, Nancy E. Cooke, Stephen A. Liebhaber> ;Molecular and Cellular Biology. 2015 May 1
• 1 citations
  Autonomous actions of the human growth hormone long-range enhancer.
  Eung Jae Yoo, Christopher D. Brown, Yu-Cheng Tsai, Nancy E. Cooke, Stephen A. Liebhaber> ;Nucleic Acids Research. 2015 Feb 27
• 132 citations
  Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia.
  Yumi Yashiro-Ohtani, Hongfang Wang, Chongzhi Zang, Kelly L. Arnett, Will Bailis, Yugong Ho, Birgit Knoechel, Claudia Lanauze, Lumena Louis, Katherine S. Forsyth, Sujun...> ;Proceedings of the National Academy of Sciences of the United States of America. 2014 Nov 18
• 6 citations
  Tissue specific CTCF occupancy and boundary function at the human growth hormone locus
  Yu-Cheng Tsai, Nancy E. Cooke, Stephen A. Liebhaber> ;Nucleic Acids Research. 2014 Apr 1
• 28 citations
  Cytoplasmic Poly(A) Binding Protein C4 Serves a Critical Role in Erythroid Differentiation
  Hemant K. Kini, Jian Kong, Stephen A. Liebhaber> ;Molecular and Cellular Biology. 2014 Apr 1
• 11 citations
  Specific enrichment of the RNA-binding proteins PCBP1 and PCBP2 in chief cells of the murine gastric mucosa.
  Louis R. Ghanem, Priya Chatterji, Stephen A. Liebhaber> ;Gene Expression Patterns. 2014 Jan 28
• 35 citations
  αCP Poly(C) binding proteins act as global regulators of alternative polyadenylation.
  Xinjun Ji, Ji Wan, Melanie Vishnu, Yi Xing, Stephen A. Liebhaber> ;Molecular and Cellular Biology. 2013 Jul 1
• 4 citations
  Identification of a Secondary Promoter within the Human B Cell Receptor Component Gene hCD79b
  Eung Jae Yoo, Nancy E. Cooke, Stephen A. Liebhaber> ;The Journal of Biological Chemistry. 2013 Jun 21
• 17 citations
  Distinct chromatin configurations regulate the initiation and the maintenance of hGH gene expression.
  Yugong Ho, Brian M. Shewchuk, Stephen A. Liebhaber, Nancy E. Cooke> ;Molecular and Cellular Biology. 2013 May 1
• 47 citations
  Haploinsufficiency of the autism candidate gene Neurobeachin induces autism-like behaviors and affects cellular and molecular processes of synaptic plasticity in mice.
  Kim Nuytens, Ilse Gantois, Pieter Stijnen, Emilia Iscru, Annelies Laeremans, Lutgarde Serneels, Lien Van Eylen, Stephen A. Liebhaber, Koen Devriendt, Detlef Balschun, ...> ;Neurobiology of Disease. 2013 Mar 1
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Journal Articles

• A Cytosine-Rich Splice-Regulatory Determinant Enforces Functional Processing of the Human Α-globin Gene Transcript  
  Stephen Liebhaber, MD, Blood
• Transcriptome Analyses of Female Somatotropes and Lactotropes Reveal Novel Regulators of Cell Identity in the Pituitary  
  Stephen Liebhaber, MD, Endocrinology
• Long-range looping of a locus control region drives tissue-specific chromatin packing within a multigene cluster  
  Tsai, Yu-Cheng, Cooke, N E, and Liebhaber, SA, Nucleic Acids Research, 1/1/2016
• alphaCP binding to a Cytosine-rich Subset of Polypyrimidine Tracts Drives a Novel Pathway of Cassette Exon Splicing in the Mammalian Transcriptome  
  Ji, Xinjun; Park, Juw Won; Bahrami-Samani, Emad; Lin, Lan; Duncan-Lewis, Christopher; Pherribo, Gordon; Xing, Yi; Liebhaber, Stephen, Nucleic Acids Research, 1/1/2016
• Autonomous Actions of the Human Growth Hormone Long-Range Enhancer  
  Yoo. Eung Jae, Brown. Christopher D., Tsai. Yu-Cheng. Cooke, Nancy E., and Stephen A. Liebhaber, Nucleic Acids Research, 1/1/2015
• An auto-regulatory pathway establishes the definitive chromatin conformation at the Pit-1 locus  
  Ho Y, Cooke NE, Liebhaber SA, Mol Cell Biol, 1/1/2015
• Resistance of mRNAs with AUG-proximal nonsense mutations to nonsense-mediated decay reflects variables of mRNA structure and translational activity  
  Pereira, Francisco; Teixeira, Alexandre; Kong, Jian; Barbosa, Cristina; Silva, Ana Luisa; Marques-Ramos, Ana; Liebhaber, Stephen; Romao, Luisa, Nucleic Acids Research, 1/1/2015
• The Poly(C) binding protein Pcbp2, and its retrotransposed derivative Pcbp1, are independently essential to mouse development  
  Ghanem, Louis R., Kromer, Andrew, Silveman, Ian M., Chatterji, Priya, Traxler, Elizabeth, Penzo-Mendez, Alfredo, Weiss, Mitchell J., Stanger, Ben Z., Liebhaber, Stephen A, Mol Cell Biol, 1/1/2015
• Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD  
  Marie-Laure Sobrier, Yu-Cheng Tsai, Christelle Pérez, Bruno Leheup, Tahar Bouceba, Philippe Duquesnoy, Bruno Copin, Daria Sizova, Alfredo Penzo, Ben Z. Stanger,..., Human Molecular Genetics, 1/1/2015
• The Cytoplasmic poly(A) Binding Protein, PABPC4, Serves a Critical Role in Erythroid Differentiation  
  Kini HK, Kong, J, and Liebhaber SA, Mol Cell Biol, 1/1/2014
• Tissue Specific CTCF Occupancy and Boundary Function at the Human Growth Hormone Locus  
  Tsai, Y-C, Cooke, NE, and Liebhaber, SA, Nucleic Acids Research, 1/1/2014
• Specific enrichment of the RNA-binding proteins PCBP1 and PCBP2 in chief cells of the murine gastric mucosa  
  Ghanem, LR, Chatterji, P., and Liebhaber, SA., Gene Expression Patterns, 1/1/2014
• Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia  
  Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, Bernstein B..., Proc Natl Acad Sci U S A, 1/1/2014
• Haploinsufficiency of the autism candidate gene Neurobeachin induces autism-like behaviors and affects cellular and molecular processes of synaptic plasticity in mice  
  Nuytens K, Gantois I, Stijnen P, Iscru E, Laeremans A, Serneels L, Van Eylen L, Liebhaber SA, Devriendt K, Balschun D, Arckens L, Creemers JW, D'Hooge R, Neurobiology of disease, 1/1/2013
• Distinct chromatin configurations regulate the initiation and the maintenance of hGH gene expression  
  Ho Y, Shewchuk BM, Liebhaber SA, Cooke NE, Mol Cell Biol, 1/1/2013
• alphaCP Poly(C) binding proteins act as global regulators of alternative polyadenylation  
  Ji X, Wan J, Vishnu M, Xing Y, Liebhaber SA, Mol Cell Biol, 1/1/2013
• Identification of a secondary promoter within the human B cell receptor component gene hCD79b  
  Yoo EJ, Cooke NE, Liebhaber SA, Journal of biological chemistry, 1/1/2013
• Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1alpha-mediated mRNA transcription and continuous protein synthesis  
  Natsuizaka M, Naganuma S, Kagawa S, Ohashi S, Ahmadi A, Subramanian H, et al, Faseb J, 1/1/2012
• The poly(rC)-binding protein alphaCP2 is a noncanonical factor in X laevis cytoplasmic polyadenylation  
  Vishnu MR, Sumaroka M, Klein PS, Liebhaber SA, RNA, 1/1/2011
• Depletion of the poly(C) binding proteins alphaCP1 and 2 from K562 cells leads to p53-independent induction of cyclin dependent kinase inhibitor p21WAF and G1 arrest  
  Shelly A. Waggoner, Gregg J. Johannes, and Stephen A. Liebhaber, J. Biol. Chem., 1/1/2009
• Proximity of the Poly(A)-Binding Protein to a Premature Termination Codon Inhibits Mammalian Nonsense Mediated mRNA Decay  
  Silva, Ana Luisa, Ribeiro Patricia, Inacio Angela,. Liebhaber Stephen A, and Luisa Romao, RNA, 1/1/2008
• Hypoxia-mediated Selective mRNA Translation by an Internal Ribosome Entry Site Independent Mechanism  
  Young, R M., Wang, S-J., Gordan, J D., Ji, Xinjun, Liebhaber, SA. and Simon, M. C., J. Biol. Chem., 1/1/2008
• The Juxtaposition of a Promoter with a Locus Control Region Transcriptional Domain Activates Gene Expression  
  Ho, Yugong, Tadevosyan, Aeksey, Liebhaber, Stephen A., and Nancy E. Cooke., EMBO Reports, 1/1/2008
• Effects of Local mRNA Structure on Post-transcriptional Gene Silencing  
  Rudnick, S. I., Jyothishmathi Swaminathan, Marina Sumaroka, Stephen Liebhaber and Alan M.Gewirtz, Proc Natl Acad Sci, 1/1/2008
• Igb(CD79b) mRNA expression in chronic lymphocytic leukemia cells correlates with immunoglobulin heavy chain gene mutational status but does not serve as an independent...  
  Cajiao, I., Sargent R., Elstrom R., Cooke N.E. , Bagg A., and Liebhaber SA., Am J Hematology, 1/1/2007
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Books/Book Chapters

• Encyclopedia of the Human Genome/Encyclopedia of Life Sciences 
  Chapter: mRNA Stability and the Control of Gene Expressio 
  Ji, Xinjun and Liebhaber S.A.Nature Publishing Group2007
• Distinct epigenetic pathways activate the human growth hormone genes in pituitary and placenta 
  Chapter: Distinct epigenetic pathways activate the human growth hormone genes in pituitary and placenta 
  Cooke N, Ho Y, Shewchuk B, Kimura A, Elefant F, Cajiao I, and Liebhaber S.2004
• Distinct epigenetic pathways activate the human growth hormone genes in pituitary and placenta 
  Cooke N, Ho Y, Shewchuk B, Kimura A, Elefant F, Cajiao I, and Liebhaber S.2004
• Gene Tranasfer and Expression in Mammalian Cells. (part of the series New Comprehensive Biochemistry) 
  Chapter: Pathways of Mammalian Messenger RNA Degradation 
  Page 495 - 513Inacio A., and Liebhaber S.A.Elsevier Science Press2003
• Trends in Endocrinology and Metabolism 
  Chapter: Activation of the human GH gene cluster: roles for targeted chromatin modification 
  Ho Y, Liebhaber SA., and Cooke N.E.2003
• Encyclopedia of the Human Genome/Encyclopedia of Life Sciences 
  Chapter: mRNA Stability and the Control of Gene Expression 
  Liebhaber S.A.Nature Publishing Group2002
• Disorders of Hemoglobin 
  Chapter: Pathophysiology of the alpha-Thalassemias 
  Liebhaber, S.A. and Schrier, S.L.Editors: M Steinberg, B Forget, D. Higgs, and R. Nagel.Cambridge Press2001
• Encyclopedia of Molecular Medicine 
  Chapter: Locus Control Regions 
  Page 1953 - 1956Cooke, N.E. and Liebhaber, S.A.John Wiley and Sons, Inc.2001
• Quarterly Review of Biology 
  Chapter: Book Review: Eucaryotic mRNA Processing. Frontiers in Molecular Biology 
  Liebhaber, S.A.1999
• Seventh Cooley’s Anemia Symposium. Annals of the New York Academy of Sciences 
  Chapter: Expression and developmental control of the human a-globin gene cluster 
  Liebhaber, S.A., and Russell, J.E.1998
• Handbook of Physiology 
  Chapter: Regulation of growth hormone gene expression 
  Page 163 - 185Cooke, N.E. and Liebhaber, S.A.Editors: Jack Kostyo.Academic Press, Publishers1998
• Progress in Nucleic Acid Research and Molecular Biology 
  Chapter: The role of mRNA stability in the control of globin gene expression 
  Russell, J.E., Morales, J., and Liebhaber, S.A.1997
• Nucleic Acids Research Symposia Series No. 36 pp. 29-32 
  Chapter: mRNA stability and the control of gene expression 
  Liebhaber, S.A.Oxford University Press, Publishers1997
• The Somatotrophic Axis and the Reproductive Process in Health and Disease 
  Chapter: The gestational physiology of the growth hormone gene family 
  Page 124 - 141Cooke, N.E., Jones, B.K., Salzman, A., Russell, J.E., Misra-Press, A., Urbanek, M.A., Liebhaber, S.A.Editors: Adashi, E.Y., Thornton, M.O..Springer-Verlag, New York, NY1995
• Proceedings of the 9th Conference on Hemoglobin Switching 
  Chapter: Cis and trans control of globin mRNA stability 
  Liebhaber, S.A., Wang, X., Kiledjian, M., and Weiss, I.M.1995
• Vitamins and Hormones 
  Chapter: Molecular biology of the growth hormone-prolactin gene system 
  Page 385 - 495Cooke, N.E., and Liebhaber, S.A.Academic Press Publishers1994
• Human Protein Date 
  Chapter: Cysteine-rich protein 
  Cooke, N.E., Liebhaber, S.A.Editors: A. Haeberli.VCH Verlagsges, mbH, Weinham, Germany1993
• Human Growth Hormone: Basic and Clinical Aspects 
  Chapter: Growth hormone gene expression in pituitary and placenta 
  Cooke, N.E., and Liebhaber, S.A.Editors: Shiverick, K.T., Rosenbloom, A.L..CRC Press, Boca Raton, FL1993
• Gene Regulation: Biology of Antisense RNA and DNA 
  Chapter: Inhibition of mRNA translation by antisense sequences 
  Page 163 - 174Liebhaber, S.A., and Russell, J.E., Cash, F.E., and Eshleman, S.S.Editors: Erickson, R.P. and Izant J.G..Raven Press1992
• Advances in Genome Biology 
  Chapter: Molecular genetics of thalassemia 
  Page 283 - 353Russell, J.E., and Liebhaber, S.A.JAI Press, Inc.1992
• Trophoblast Cells: Pathways for Maternal-Embryonic Communications 
  Chapter: Placental expression and function of the human growth hormone gene family 
  Page 222 - 239Cooke, N.E., Jones, B.K., Urbanek, M., Misra-Press, A., Lee, A.K., Russell, J.E., MacLeod, J.N. and Liebhaber, S.A.Editors: M.J. Soares, S. Handwerger, F. Talamantes.Springer-Verlag, New York, NY1992
• Hemoglobin Switching: Proceedings of the Seventh Conference on Hemoglobin Switching 
  Chapter: Regulation of the human embryonic and adult a-globin genes in transgenic mice 
  Page 55 - 69Albitar, M., Katsumata, M., and Liebhaber, S.A.Editors: G. Stamatoyannopoulos and A.W. Nienhuis.1991
• Methods in Hematology 
  Chapter: Use of in vitro translation techniques to study gene expression 
  Page 169 - 190Liebhaber, S.A.Editors: Benz, E.J., Jr..Churchill Livingstone, Edinburgh, Scotland1988
• Disease-A-Month 
  Chapter: Update On Hemoglobinopathies 
  Liebhaber, S.A. and Manno, K.1983
• Thalassemia: Recent Advances in Detection and Treatment 
  Chapter: Molecular pathology of alpha-thalassemia 
  Page 35 - 45Liebhaber, S.A., and Kan, Y.W.Editors: Cao, A., Carcassi, H., and Rowley, P..Alan R. Liss, Inc., New York, NY1982
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Lectures

• Mechanistic Analysis of a Long-range Enhancer 
  Snowbird, UT - 1/18/2014
• Long-range Gene Activation 
  1/1/2011
• Pathways of Chromatin Activation at the Human Growth Hormone Locus 
  1/1/2010
• Mechanisms of mRNA stabilization 
  Lisbon, Portugal - 1/1/2009
• Long-range transcriptional control 
  Center for Gene Regulation, Barcelona, Spain - 1/30/2007
• mRNA Stability and decay 
  National Institutes of Health, Lisbon, Portugal - 1/24/2007
• Transcriptional interactions at a complex mammalian locus 
  Faculte Medecine, Necker Hospital, Paris - 1/17/2007
• mRNA surveillance pathways 
  1/15/2007
• Studies on mRNA decay 
  1/8/2007
• mRNA surveillance and decay 
  CNRS Research Institute, Roscoff, France - 1/2/2007
• Studies on mRNA Stability 
  Ohio State University, Columbus, OH - 1/11/2006
• Transcriptional Interactions within a complex mammalian locus: Do good neighbors need good fences? 
  Ohio State University, Columbus, OH - 1/10/2006
• Studies on mRNA Stability and Decay 
  1/10/2006
• Integration of post-transcriptional controls in the determination of mRNA function 
  St. Louis Unversity, St. Louis, MO - 1/1/2004
• Long-range transcriptional activation 
  Madison, WI - 1/1/2002
• Distinct Mechanisms of Long-range Gene Activation 
  Oxford, UK - 1/1/2002
• RNA-protein interactions in the determination of mRNA function 
  Lisbon, Portugal - 1/1/2002
• Chromatin Modification and Complex Functions of a Multilocus LCR 
  1/1/2001
• A Locus Control Region Determinant Mediates Single-Site Recruitment and Bidirectional Spreading of HAT Activity with Coincident Gene Activation 
  Santa Fe, NM - 1/1/2001
• mRNA Stability; Roles in Globin Genen Expression and Thalassemic States 
  Athens, Greece - 1/1/2001
• Role of High Level mRNA Stabilization in the Expression and Developmental Control of the Human alpha-Goblin Gene Cluster 
  1/1/2000
• Human Growth Hormone Gene Cluster: Chromatin Activation by a Locus Control Region 
  1/1/2000
• Role of mRNA Stabilization in Expression of Developmental Control of the Human alpha-Goblin Gene Cluster 
  Orcas Island, WA - 1/1/2000
• Structure and Function of an mRNP Stability Complex 
  1/1/1999
• alpha-Goblin Gene Switching 
  Crete, Greece - 1/1/1999
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Other

• Regulation of the human growth hormone gene cluster by locus control region 
  Kimura A, Cooke NE, Liebhaber SA, JSCE Newsletter
  1/1/2006