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Office
26339 Valley View Ave
Carmel, CA 93923Phone+1 831-621-4044- Is this information wrong?
Education & Training
- Johns Hopkins UniversityResidency, Neurology, 1979 - 1984
- Johns Hopkins UniversityPh.D., 1978 - 1980
- Johns Hopkins University School of MedicineClass of 1979
- Cornell UniversityA.B., 1972 - 1975
Certifications & Licensure
- CA State Medical License 1984 - 2026
- American Board of Psychiatry and Neurology Neurology
Awards, Honors, & Recognition
- Standard of Excellence Award Johnson & Johnson, 2007
- Elected to The Society of Scholars Johns Hopkins University, 1995
- Max Hamilton Memorial Prize for significant contributions to the field of Psychopharmacology Collegium Internationale Neuro-Pychopharmacologicum, 1994
- Syntex Award for Receptor Pharmacology 1993
- Harold G. Wolff Award for the best headache research paper American Association for the Study of Headache, 1993
- Daniel H. Efron Award for excellence in basic neuropharmacology research American College of Neuropsychopharmacology, 1993
- First Irvine H. Page Lecturer 1990
- Fellow Stanley Foundation Fellowship, 1989
- Awardee ARCS Foundation, 1988
- Scholar Award McKnight Foundation, 1986
- Alfred P. Sloan Fellowship 1985
- John A. and George L. Hartford Fellowship 1985
- Sandoz Award for excellence in the field of Pharmacology 1979
- Phi Beta Kappa 1975
- Scholar School of Arts and Sciences, 1972
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Publications & Presentations
PubMed
- Clinical trials update 2015: Year in review.Stephen J. Peroutka> ;Headache. 2016 Jan 1
- 5 citationsClinical trials update 2014: year in review.Stephen J. Peroutka> ;Headache. 2015 Jan 1
- 98 citationsWhat Turns on a Migraine? A Systematic Review of Migraine Precipitating FactorsStephen J. Peroutka> ;Current Pain and Headache Reports. 2014 Aug 28
- 9 citationsCalcitonin gene-related peptide targeted immunotherapy for migraine: progress and challenges in treating headacheStephen J. Peroutka> ;Biodrugs. 2014 Jan 23
- 7 citationsClinical trials update. 2013: year in review.Stephen J. Peroutka> ;Headache. 2014 Jan 1
- 1 citationsNot all CGRP antagonists are created equal.Stephen J. Peroutka> ;Headache. 2013 Jun 1
- 2 citations2011: year in review.Stephen J. Peroutka> ;Headache. 2012 Jan 1
- 9 citationsBinding potency of paroxetine analogues for the 5-hydroxytryptamine uptake complex.Chester A. Mathis, John M. Gerdes, Joel D. Enas, John M. Whitney, Scott E. Taylor, Yi Zhang, Dennis J. McKenna, Sona Havlik, Stephen J. Peroutka> ;The Journal of Pharmacy and Pharmacology. 2011 Apr 12
- 4 citations2010: Year in ReviewStephen J. Peroutka> ;Headache. 2011 Jan 1
- 8 citations2008: the year in review.Stephen J. Peroutka> ;Headache. 2009 May 1
- 20 citationsArtifactual High-Affinity and Saturable Binding of [3H]5-Hydroxytryptamine Induced by Radioligand OxidationStephen J. Peroutka, Pamela J. Ison, David U. Liu, Ronald W. Barrett> ;Journal of Neurochemistry. 2006 Oct 5
- 281 citationsPharmacological differentiation and characterization of 5-HT1A, 5-HT1B, and 5-HT1C binding sites in rat frontal cortex.Stephen J. Peroutka> ;Journal of Neurochemistry. 2006 Oct 5
- 103 citationsNEUROGENIC INFLAMMATION AND MIGRAINE: IMPLICATIONS FOR THE THERAPEUTICSStephen J. Peroutka> ;Molecular Interventions. 2005 Oct 1
- 6 citationsRe: a sympathetic view of "2003 Wolff Award: possible parasympathetic contributions to peripheral and central sensitization during migraine".Stephen J. Peroutka> ;Headache. 2004 Jul 1
- 35 citationsAnalgesic safety and efficacy of diclofenac sodium softgels on postoperative third molar extraction painJohn R. Zuniga, Ceib Phillips, Daniel A. Shugars, James A. Lyon, Stephen J Peroutka, James Swarbrick, Charles Bon> ;Journal of Oral and Maxillofacial Surgery. 2004 Jul 1
- 29 citationsEfficacy of diclofenac sodium softgel 100 mg with or without caffeine 100 mg in migraine without aura: a randomized, double-blind, crossover studyStephen J. Peroutka, James A. Lyon, James Swarbrick, Ken Kolodner, Jerome Goldstein> ;Headache. 2004 Feb 1
- 162 citationsMigraine: a chronic sympathetic nervous system disorder.Stephen J. Peroutka> ;Headache. 2004 Jan 1
- 17 citationsThe Third Intracellular Loop of the 5-Hydroxytryptamine2A Receptor Determines Effector Coupling SpecificityDonna Oksenberg, Sona Havlik, Stephen J. Peroutka, Avi Ashkenazi> ;Journal of Neurochemistry. 2002 Nov 23
- 8 citationsSympathetic Look at Genetic Basis of MigraineStephen J. Peroutka> ;Headache. 2002 May 1
- 10 citationsSerum glucose regulation and headache.Stephen J. Peroutka> ;Headache. 2002 Apr 1
- 20 citationsGlucose regulation in headache: implications for dietary managementKaren N Hufnagl, Stephen J Peroutka> ;Expert Review of Neurotherapeutics. 2002 May 1
- 104 citationsSingle-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine.Linda McCarthy, David A. Hosford, John H. Riley, Michael I. Bird, Nicola J. White, Duncan R. Hewett, Stephen J. Peroutka, Lyn R. Griffiths, Pete R. Boyd, Rod A. Lea, S...> ;Genomics. 2001 Dec 1
- Analysis of Internet sites for headache.Peroutka SJ> ;Cephalalgia. 2001-02-01
- 11 citationsThe value of genotyping for apolipoprotein E alleles in relation to vitamin E supplementation.Stephen J. Peroutka, Darlene M Dreon> ;European Journal of Pharmacology. 2000 Dec 27
- 7 citationsStep-wise analysis of polymorphisms in the human dopamine D2 receptor geneKeith W. Jones, Stephen J. Peroutka> ;Neuropharmacology. 1998 Jun 1
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Journal Articles
- Clinical Trials Update 2013: the year in reviewPeroutka SJ, Headache, 1/1/2014
- Calcitonin gene-related peptide targeted immunotherapy for migraine: progress and challenges in splitting the headachePeroutka SJ, BioDrugs, 1/1/2014
- Clinical Trials Update 2012: the year in reviewPeroutka SJ, Headache, 1/1/2013
- Not all CGRP antagonists are created equalPeroutka SJ, Headache, 1/1/2013
- Clinical Trials Update 2011: the year in reviewPeroutka SJ, Headache, 1/1/2012
- Clinical Trials Update 2010: the year in reviewPeroutka SJ, Headache, 1/1/2011
- Clinical Trials Update 2009: the year in reviewPeroutka SJ, Headache, 1/1/2010
- Clinical Trials Update 2008: the year in reviewPeroutka SJ, Headache, 1/1/2009
- Neurogenic inflammation and migraine: implications for therapeuticsPeroutka SJ, Mol Interv, 1/1/2005
- Migraine: A chronic sympathetic nervous system disorderPeroutka SJ, Headache, 1/1/2004
- A randomized, double-blind, crossover study of the efficacy of 100 mg diclofenac sodium softgel formulation with or without 100 mg caffeine in the acute treatment of m...Peroutka SJ, Lyon JA, Swarbrick J, Lipton RB, Kolodner K, Goldstein J, Headache, 1/1/2004
- A Sympathetic View of “2003 Wolff Award: Possible Parasympathetic Contributions to Peripheral and Central Sensitization During Migraine”Peroutka SJ, Headache, 1/1/2004
- Analgesic safety and efficacy of diclofenac sodium softgels on postoperative third molar extraction painZuniga JR, Phillips CL, Shugars D, Lyon JA, Peroutka SJ, , Swarbrick J, Bon C, Journal of Oral and Maxillofacial Surgery, 1/1/2004
- Serum glucose regulation and headachePeroutka SJ, Headache, 1/1/2002
- Sympathetic look at genetic basis of migrainePeroutka SJ, Headache, 1/1/2002
- Glucose regulation in headache: Implications for dietary managementHufnagl KN, Peroutka SJ, Expert Reviews in Neurotherapeutics, 1/1/2002
- Analysis of Internet sites for headachePeroutka SJ, Cephalalgia, 1/1/2001
- Medical utility of apoe allele determination in assessing the need for antioxidant therapyDreon DM, Peroutka SJ, Medical Hypotheses, 1/1/2001
- Single nucleotide polymorphism (SNP) alleles in the Insulin Receptor (INSR) gene are associated with typical migraineMcCarthy LC, Hosford DA, Riley JH, Bird MI, White NJ, Hewett DR, Peroutka SJ, Griffiths LR, Boyd PR, Lea RA, Bhatti SM, Hosking LK, Hood CM, Jones KW, Handley AR, Rall..., Genomics, 1/1/2001
- Migraine with Aura Susceptibility Locus on Chromosome 19p13 is Distinct from the Familial Hemiplegic Migraine LocusJones KW, Ehm MG, Boyd PR, Peroutka SJ, Genomics, 1/1/2001
- Review of “Migraine and Headache Pathophysiology”Peroutka SJ, Headache, 1/1/2000
- The value of genotyping for apolipoprotein E alleles in relation to vitamin E supplementationPeroutka SJ, Dreon DM, European Journal of Pharmacology, 1/1/2000
- Molecular variation within the dopamine receptor DRD2 gene in migrainePeroutka SJ, The Journal of Headache and Pain, 1/1/2000
- Detection of mRNAs and alternatively spliced transcripts of dopamine receptors in rat peripheral sensory and sympathetic gangliaXie GX, Jones KW, Peroutka SJ, Palmer PP, Brain Research, 1/1/1998
- Comorbid migraine, anxiety and depression is associated with dopamine D2 receptor (DRD2) NcoI allelesPeroutka SJ, Price SC, Wilhoit TL, Jones KW, Molecular Medicine, 1/1/1998
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Books/Book Chapters
- Autonomic FailureChapter: The molecular genetics of the autonomic nervous systemPeroutka SJEditors: Mathias CJ, Bannister R.Oxford University PressEdition 5th,2013
- Principals of Drug Therapy in NeurologyChapter: MigrainePage 152 - 172Peroutka SJEditors: Johnston MV and Gross RA.Oxford University PressEdition 2nd,2008
- Molecular NeurologyChapter: Genetic Disorders of the Autonomic Nervous SystemPage 321 - 332Peroutka SJEditors: Stephen G. Waxman.Elsevier2007
- Hot Topics in Headache: The Migraine TrustChapter: Headache doctors and headache patients working togetherPage 16 - 20Peroutka SJEditors: Swain D.2002
- Hot Topics in Headache: The Migraine TrustChapter: Take these two websites and call me in the morningPage 78 - 80Peroutka SJEditors: Swain D.2002
- Harrison’s Principles of Internal MedicineChapter: Headache, including migraine and cluster headachePage 70 - 79Raskin NH, Peroutka SJEditors: Braunwald E, Fauci A, Kasper DL, Hauser SL, Longo DL, Jameson JL.Edition 15th,2001
- The Management of Acute and Chronic Pain the Use of the “Tools of the Trade” (Proceedings of the “Worldwide Pain Congress”)Chapter: Analysis of Internet sites for painPage 109 - 115Peroutka SJ, Dreon DMEditors: Krames E, Reig E.2000
- Genetics of Headache DisordersChapter: Experience from other complex disorders: The utility of genetic association studiesPeroutka SJEditors: Olesen J.Lippincott-Raven Publishers, Philadelphia, PA2000
- Encyclopedia of NeuroscienceChapter: Serotonin (5-hydroxytryptamine) receptor subtypes: Clinical relevancePage 1842 - 1845Peroutka SJ, Mahler EEditors: Adelman GA, Smith BH.Edition 2nd,1999
- Autonomic FailureChapter: Molecular genetic approaches to the autonomic nervous systemPage 33 - 36Peroutka SJEditors: Mathias CJ, Bannister R.Oxford University Press1999
- Blue Books of Practical Neurology: HeadacheChapter: The genetic evaluation of migrainePage 107 - 114Peroutka SJEditors: Goadsby PJ and Silberstein SD.Butterworth Heinemann, Newton, MA1997
- Functional Genomics: Drug Discovery from Gene to Screen, IBC Biomedical Library SeriesChapter: Multi-phenotypic Allelic Profiling: A novel strategy for functional genomicsPeroutka SJInternational Business Communications, Inc., Southborough, MA1997
- Serotonin Receptors and Their LigandsChapter: 5-Hydroxytryptamine receptor subtypesPage 3 - 13Peroutka SJEditors: Olivier B, Van Wijngaarden I, Soudijn W.Elsevier Science B.V., Amsterdam1997
- Principals of Medical Biology Volume 8A: Molecular & Celular PharmacologyChapter: 5-Hydroxytryptamine receptorsPage 61 - 74Peroutka SJ, Howell TAEditors: Bittar EE, Bittar N.JAI Press, Inc.1997
- Towards Migraine 2000Chapter: The genetic evaluation of migraine: Clinical database requirementsPage 35 - 48Peroutka SJ, Howell TAEditors: Rose FC.Elsevier Science B.V.1996
- Experimental Headache ModelsChapter: Future development of drugs for headache disordersPage 345 - 349Peroutka SJEditors: Olesen J and Moskowitz MA.Lippincott-Raven Publishers, Philadelphia, PA1995
- Goodman and Gilman's The Pharmacological Basis of TherapeuticsChapter: Drugs effective in the treatment of migrainePage 487 - 502Peroutka SJEditors: Hardman JG and Limbird LE.Edition 9th,1995
- Handbook of Receptors and Channels: G Protein-coupled ReceptorsEditors: Peroutka SJ.CRC Press, Boca Raton, FL1994
- CRC Handbook of Receptors and Channels: G Protein-coupled ReceptorsChapter: Endothelin receptorsPage 125 - 128Peroutka SJEditors: Peroutka SJ.1994
- CRC Handbook of Receptors and Channels: G Protein-coupled ReceptorsChapter: 5-Hydroxytryptamine receptorsPage 209 - 236Peroutka SJEditors: Peroutka SJ.1994
- Serotonin (5-HT) in neurologic and psychiatric disordersChapter: Evolution of 5-HT receptors and clinical relevancePage 29 - 38Peroutka SJ, Howell TAEditors: Ferrari D.1994
- 50 Years of LSD: Current status and perspectives of hallucinogensChapter: 5-Hydroxytryptamine receptor interactions of D-lysergic acid diethylamidePage 19 - 26Peroutka SJEditors: Pletscher A, Ladewig D.1994
- Proceedings of the 26th Annual Recent Advances in NeurologyChapter: Thrombolytic agents in acute strokePage 106 - 114Peroutka SJUniversity of California at San Francisco School of Medicine, San Francisco, CA1993
- Headache: A Clinician's Guide to Diagnosis, Pathophysiology and Treatment StrategiesChapter: Serotonin receptor pharmacology in migrainePage 19 - 23Peroutka SJEditors: Rapaport AM, Sheftell F.PMA Publishing Company, Los Alamitos1993
- Trends in Drug ResearchChapter: Pharmacochemistry of 5-HT receptor subtype selective compoundsPage 83 - 95Peroutka SJEditors: V. Claassen.1993
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Abstracts/Posters
- NGX-1998: Phase 2 Proof of Concept Study in Postherpetic Neuralgia Using a Novel Topical Liquid Formulation of CapsaicinPeroutka SJ, Tobias J, Vanhove G, Bhattacharya S, 14th World Congress on Pain Abstracts, 1/1/2012
- Prostaglandins in Migraine: The Headache Stuff of Harold G. WolffPeroutka SJ, Cephalalgia, 1/1/2004
- Molecular Pathway Analysis of Allodynia: The Primary Role of ProstaglandinsPeroutka SJ, Headache, 1/1/2004
- In Memoriam: The Neurogenic Theory of Migraine (1979-2004)Peroutka SJ, Headache, 1/1/2004
- Migraine: A chronic sympathetic nervous system disorderPeroutka SJ, Headache, 1/1/2003
- The efficacy of existing acute migraine agents: The need for improved clinical approaches to the acute management of migrainePeroutka SJ, Headache, 1/1/2003
- Pharmacological analysis existing prophylactic migraine agents: Inhibition of sympathetic nervous system activation as a common mechanism of actionPeroutka SJ, Cephalalgia, 1/1/2003
- Single nucleotide polymorphism (SNP) alleles in the Insulin Receptor (INSR) gene are associated with migraineWhite NJ, Hosford DA, Humphrey PP, Boyd PR, Griffiths LR, Peroutka S, Roses AD, Purvis IJ, McCarthy LC, Cephalalgia, 1/1/2001
- A randomized, double-blind, crossover study of the efficacy of a 100 mg diclofenac sodium softgel formulation with or without 100 mg caffeine in the acute treatment of...Goldstein J, Lipton R, Kolodner K, Swarbrick J, Lyon J, Dreon D, Peroutka S, Cephalalgia, 1/1/2001
- Analgesic safety and efficacy of diclofenac softgels in postoperative dental painZuniga J, Phillips C, Shugars D, Rogers L, Lyon J, Peroutka S, Swarbrick J, Journal of Oral and Maxillofacial Surgery, 1/1/2001
- Migraine 2000: Beyond the triptansPeroutka S, Gebhart G, McCall R, Mermelstein P, Abstracts of the Thirty-third Annual Winter Conference on Brain Research, 1/1/2000
- Analysis of Internet sites for headachePeroutka SJ, The 13th Annual Practicing Physician’s Approach to the Difficult Headache Patient Abstracts, 1/1/2000
- Analysis of Internet sites for migrainePeroutka SJ, Abstracts of the 42nd Annual Scientific Meeting of the American Headache Society, 1/1/2000
- Analysis of Internet sites for painDreon DM, Peroutka SJ, Worldwide Pain Congress Abstracts, 1/1/2000
- Sensitivity of the four level categorical scale vs. The visual analogue scale in assessing headache pain intensity in migraineursDreon DM, Peroutka SJ, Cephalalgia, 1/1/2000
- Effect of metoclopramide and caffeine on the rapid oral absorption of diclofenacSwarbrick J, Lyon, Jr. JA, Peroutka SJ, Cephalalgia, 1/1/2000
- A proposed editorial review system for “headache” information on the internetPeroutka SJ, Cephalalgia, 1/1/2000
- Serotonin receptor variants in disease: New therapeutic opportunitiesPeroutka SJ, Abstracts of the Symposium on Serotonin Receptors, 10/1/1997
- New advances in the treatment of migraineMcCall RB, Phebus L, Hall E, Gebhart G, Peroutka S, Abstracts of the Thirtieth Annual Winter Conference on Brain Research, 1/1/1997
- Autosomal dominant vertical and horizontal nystagmus: A vestibulocerebellar syndrome that does not map to chromosome 19pMay EF, Stankus SJ, Coughlin WF, Jones KW, Peroutka SJ, Neurology, 1/1/1997
- Beyond monotherapy: Rational polytherapy in migrainePeroutka SJ, Headache, 1/1/1997
- Mendelian inheritance of comorbid migraine, anxiety and depressionPeroutka SJ, Mahler E, Price SC, Headache, 1/1/1997
- Polymorphisms within the CACN1A4 gene are not associated with migraine without aura or migraine with auraPeroutka SJ, Wilhoit TL, Boatwright M, Derksen M, Jones KW, Headache, 1/1/1997
- Experience from other complex disorders: The utility of association genetic studiesPeroutka SJ, Abstracts of the 8th International Headache Research Seminar, 1/1/1997
- A novel clinical mapping strategy based on a multi-phenotypic analyses of polymorphismsJones KW, Xie GX, Peroutka SJ, American Society for Human Genetics Abstracts, 1/1/1996
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Lectures
- CGRP and MigraineBaltimore, MD - 4/1/2014
- Migraine pain: what have we learned to date?London, England - 10/1/2009
- The Biological Basis of MigraineKyoto, Japan - 10/1/2005
- Migraine and Neuronal Hyperexcitability: Insights for TherapyWashington, DC - 3/1/2005
- A Sympathetic Look at MigraineBern, Switzerland - 8/1/2004
- Migraine and the Sympathetic Nervous SystemRotterdam, Netherlands - 5/1/2003
- Media Medicine: Educating the 21st Century Headache PatientLondon, United Kingdom - 9/1/2000
- Molecular Variation within Dopamine Receptor Genes in MigraineRome, Italy - 9/1/2000
- The role of dopamine in migraineOsaka, Japan - 4/1/1999
- Genetic analysis of complex disordersCopenhagen, Denmark - 11/1/1997
- Multi-phenotypic Allelic ProfilingMonte Carlo, Monaco - 5/1/1997
- A Novel Clinical Mapping StrategyVancouver, Canada - 4/1/1996
- An overview of the genetics of migraineToronto, Canada - 9/1/1995
- The Genetic Basis of Migraine: The Future is NowLeeds Castle, United Kingdom - 6/1/1995
- Future approaches to the development of novel headache therapeuticsCopenhagen, Denmark - 11/1/1994
- 5-HT receptors and clinical relevanceCopenhagen, Denmark - 9/1/1994
- Mechanisms underlying migraine and therapeutic consequencesVienna, Austria - 9/1/1994
- Evolution of 5-HT receptors and clinical relevanceLeiden, Netherlands - 5/1/1994
- Serotonergic receptor interactions of LSDAgno, Switzerland - 10/1/1993
- Anti-migraine drug interactions with human 5-HT1 receptorsParis, France - 8/1/1993
- Pharmacochemistry of 5-HT CompoundsNoordwijkerhout, Netherlands - 5/1/1993
- Neurotrophic Factors and Diseases of the Aging Nervous SystemSan Francisco, CA - 10/1/1992
- Basic mechanisms of action of anti-migraine drugsWashington, DC - 7/1/1991
- The molecular biology of 5-HT receptor subtypesBirmingham, England - 7/1/1991
- Recent advances in the pharmacology of migraineLondon, Ontario - 10/1/1990
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Press Mentions
- PPD Awarded US Army Study to Help Develop Post-Traumatic Stress Disorder DrugsFebruary 18th, 2021
- PPD Strengthens Expertise in Neuroscience, Pediatrics and Rare DiseasesMay 11th, 2017
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