StevenCBrunerMD

PubMed

• Structural basis for phosphopantetheinyl carrier domain interactions in the terminal module of nonribosomal peptide synthetases.
  Liu, Y., Zheng, T., Bruner, S. D.> ;Chem Biol. 2011 Nov 23
• Enzyme catalysis: C-H activation is a Reiske business.
  Bruner, S. D.> ;Nat Chem. 2011 May
• Probing the active site of MIO-dependent aminomutases, key catalysts in the biosynthesis of beta-amino acids incorporated in secondary metabolites.
  Cooke, H. A., Bruner, S. D.> ;Biopolymers. 2010 Sep
• Biosynthesis: unmasking morphine.
  Dimise, E. J., Bruner, S. D.> ;Nat Chem Biol. 2010 Apr
• Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinos...
  Cooke, H. A., Guenther, E. L., Luo, Y., Shen, B., Bruner, S. D.> ;Biochemistry. 2009 Oct 13
• Structure and chemistry of 4-methylideneimidazole-5-one containing enzymes.
  Cooke, H. A., Christianson, C. V., Bruner, S. D.> ;Curr Opin Chem Biol. 2009 Oct 01
• Complex oxidation chemistry in the biosynthetic pathways to vancomycin/teicoplanin antibiotics.
  Widboom, P. F., Bruner, S. D.> ;Chembiochem. 2009 Jul 20
• Structure elucidation and biosynthesis of fuscachelins, peptide siderophores from the moderate thermophile Thermobifida fusca.
  Dimise, E. J., Widboom, P. F., Bruner, S. D.> ;Proc Natl Acad Sci U S A. 2008 Oct 07
• Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinos...
  Luo, Y., Lin, S., Zhang, J., Cooke, H. A., Bruner, S. D., Shen, B.> ;J Biol Chem. 2008 May 23
• Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM.
  Montavon, T. J., Christianson, C. V., Festin, G. M., Shen, B., Bruner, S. D.> ;Bioorg Med Chem Lett. 2008 May 15
• The mechanism of MIO-based aminomutases in beta-amino acid biosynthesis.
  Christianson, C. V., Montavon, T. J., Festin, G. M., Cooke, H. A., Shen, B., Bruner, S. D.> ;J Am Chem Soc. 2007 Dec 26
• Substrate recognition and catalysis by the cofactor-independent dioxygenase DpgC.
  Fielding, E. N., Widboom, P. F., Bruner, S. D.> ;Biochemistry. 2007 Dec 11
• Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.
  Cooke, H. A., Zhang, J., Griffin, M. A., Nonaka, K., Van Lanen, S. G., Shen, B., Bruner, S. D.> ;J Am Chem Soc. 2007 Jun 27
• The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway.
  Christianson, C. V., Montavon, T. J., Van Lanen, S. G., Shen, B., Bruner, S. D.> ;Biochemistry. 2007 Jun 19
• Structural basis for cofactor-independent dioxygenation in vancomycin biosynthesis.
  Widboom, P. F., Fielding, E. N., Liu, Y., Bruner, S. D.> ;Nature. 2007 May 17
• Rational manipulation of carrier-domain geometry in nonribosomal peptide synthetases.
  Liu, Y., Bruner, S. D.> ;Chembiochem. 2007 Apr 16
• Type II thioesterase restores activity of a NRPS module stalled with an aminoacyl-S-enzyme that cannot be elongated.
  Yeh, E., Kohli, R. M., Bruner, S. D., Walsh, C. T.> ;Chembiochem. 2004 Sep 6
• DpgC is a metal- and cofactor-free 3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase in the vancomycin biosynthetic pathway.
  Tseng, C. C., Vaillancourt, F. H., Bruner, S. D., Walsh, C. T.> ;Chem Biol. 2004 Sep
• Product-assisted catalysis in base-excision DNA repair.
  Fromme, J. C., Bruner, S. D., Yang, W., Karplus, M., Verdine, G. L.> ;Nat Struct Biol. 2003 Mar
• Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase.
  Tseng, C. C., Bruner, S. D., Kohli, R. M., Marahiel, M. A., Walsh, C. T., Sieber, S. A.> ;Biochemistry. 2002 Nov 12
• Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE.
  Bruner, S. D., Weber, T., Kohli, R. M., Schwarzer, D., Marahiel, M. A., Walsh, C. T., Stubbs, M. T.> ;Structure. 2002 Mar
• Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein.
  Norman, D. P., Bruner, S. D., Verdine, G. L.> ;J Am Chem Soc. 2001 Jan 17
• Selective inhibition of herpes simplex virus type-1 uracil-DNA glycosylase by designed substrate analogs.
  Sekino, Y., Bruner, S. D., Verdine, G. L.> ;J Biol Chem. 2000 Nov 24
• Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA.
  Bruner, S. D., Norman, D. P., Verdine, G. L.> ;Nature. 2000 Feb 24
• Structural and mechanistic studies on repair of 8-oxoguanine in mammalian cells.
  Bruner, S. D., Norman, D. P., Fromme, J. C., Verdine, G. L.> ;Cold Spring Harb Symp Quant Biol. 2000
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