TommyMikkelsenMD

Neurosurgery • Detroit, MI

Physician

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Office
2799 W Grand Blvd
Detroit, MI 48202
Phone+1 800-436-7936

Fax+1 313-916-7139
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Education & Training

University of Calgary Faculty of MedicineClass of 1983

Certifications & Licensure

MI State Medical License 1994 - 2025
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2008-2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
America's Top Doctors for Cancer Castle Connolly, 2005-2013

Clinical Trials

Study of a Drug [DCVax®-L] to Treat Newly Diagnosed GBM Brain Cancer Start of enrollment: 2006 Dec 01
Active, not recruiting
Phase 3
AQ4N in Combination With Radiotherapy and Temozolomide in Subjects With Newly Diagnosed Glioblastoma Multiforme Start of enrollment: 2006 Oct 01
Unknown status
Phase 1, Phase 2
PF-00299804 in Adult Patients With Relapsed/Recurrent Glioblastoma Start of enrollment: 2010 Apr 01
Completed
Phase 2
A Phase 1b/2 Study of PLX3397 + Radiation Therapy + Temozolomide in Patients With Newly Diagnosed Glioblastoma Start of enrollment: 2013 Jul 18
Completed
Phase 1, Phase 2
Safety and Efficacy Study of SL-701, a Glioma-Associated Antigen Vaccine To Treat Recurrent Glioblastoma Multiforme Start of enrollment: 2014 May 01
Completed
Phase 1, Phase 2
Sapanisertib Before and After Surgery in Treating Patients With Recurrent Glioblastoma Start of enrollment: 2014 May 12
Active, not recruiting
Phase 1
A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma Start of enrollment: 2019 Jul 30
Recruiting
Phase 2, Phase 3
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Publications & Presentations

PubMed

Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma.
Wajd N Al-Holou, Hanxiao Wang, Visweswaran Ravikumar, Sunita Shankar, Morgan Oneka, Ziad Fehmi, Roel Gw Verhaak, Hoon Kim, Drew Pratt, Sandra Camelo-Piragua, Corey Spe...> ;Neoplasia. 2023 Feb 1
8 citations
Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma: A P...
Linda M Liau, Keyoumars Ashkan, Steven Brem, Jian L Campian, John E Trusheim, Fabio M Iwamoto, David D Tran, George Ansstas, Charles S Cobbs, Jason A Heth, Michael E S...> ;JAMA Oncology. 2023 Jan 1
2 citations
Detection of tumor-specific DNA methylation markers in the blood of patients with pituitary neuroendocrine tumors.
Grayson A Herrgott, Karam P Asmaro, Michael Wells, Thais S Sabedot, Tathiane M Malta, Maritza S Mosella, Kevin Nelson, Lisa Scarpace, Jill S Barnholtz-Sloan, Andrew E ...> ;Neuro-Oncology. 2022 Jul 1
1 citations
Radiomics for precision medicine in glioblastoma.
Kiran Aftab, Faiqa Binte Aamir, Saad Mallick, Fatima Mubarak, Whitney B Pope, Tom Mikkelsen, Jack P Rock, Syed Ather Enam> ;Journal of Neuro-Oncology. 2022 Jan 1
29 citations
A serum-based DNA methylation assay provides accurate detection of glioma.
Thais S. Sabedot, Tathiane M. Malta, James Snyder, Kevin Nelson, Michael Wells, Ana C. deCarvalho, Abir Mukherjee, Dhananjay Chitale, Maritza S Mosella, Artem Sokolov,...> ;Neuro-Oncology. 2021 Sep 1
3 citations
Rapid real-world data analysis of patients with cancer, with and without COVID-19, across distinct health systems.
Clara Hwang, Monika A Izano, Michael A. Thompson, Shirish M. Gadgeel, James L. Weese, Tom Mikkelsen, Andrew Schrag, Mahder Teka, Sheetal Walters, Frank M. Wolf, Jonath...> ;Cancer Reports. 2021 May 20
6 citations
Randomized prospective trial of fractionated stereotactic radiosurgery with chemotherapy versus chemotherapy alone for bevacizumab-resistant high-grade glioma
David Bergman, Ankit Modh, Lonni Schultz, James Snyder, Tom Mikkelsen, Mira M. Shah, Samuel Ryu, M. Salim Siddiqui, Tobias Walbert> ;Journal of Neuro-oncology. 2020 May 22
40 citations
First-In-Human Phase I Study Of A Dual mTOR Kinase And DNA-PK Inhibitor (CC-115) In Advanced Malignancy.
Pamela N. Munster, Monica M. Mita, Amit Mahipal, John Nemunaitis, Christophe Massard, Tom Mikkelsen, Cristina Cruz, Luis Paz-Ares, Manuel Hidalgo, Dana E. Rathkopf, Ge...> ;Cancer management and research. 2019 Dec 13
60 citations
Safety and efficacy of depatuxizumab mafodotin + temozolomide in patients with EGFR-amplified, recurrent glioblastoma: results from an international phase I multicente...
Andrew B. Lassman, Martin J. van den Bent, Hui K Gan, David A. Reardon, Priya Kumthekar, Nicholas Butowski, Zarnie Lwin, Tom Mikkelsen, Louis B. Nabors, Kyriakos P. Pa...> ;Neuro-oncology. 2019 Jan 1
14 citations
Volumetric response quantified using T1 subtraction predicts long-term survival benefit from cabozantinib monotherapy in recurrent glioblastoma.
Benjamin M. Ellingson, Dana T. Aftab, Gisela Schwab, Colin Hessel, Robert J. Harris, Davis C. Woodworth, Kevin Leu, Ararat Chakhoyan, Catalina Raymond, Jan Drappatz, J...> ;Neuro-oncology. 2018 Sep 3
8 citations
Correction: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma [J Transl Med., 16, (...
Linda M. Liau, Keyoumars Ashkan, David Tran, Jian Campian, John E. Trusheim, Charles S. Cobbs, Jason Heth, Michael Salacz, Sarah A. Taylor, Stacy D. D’Andre, Fabio M. ...> ;Journal of Translational Medicine. 2018 Jun 29
122 citations
Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma
Ana C. deCarvalho, Hoon Kim, Laila M. Poisson, Mary E. Winn, Claudius Mueller, David Cherba, Julie Koeman, Sahil Seth, Alexei Protopopov, Michelle Madden Felicella, Si...> ;Nature Genetics. 2018 Apr 23
95 citations
A Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence
Camila Ferreira de Souza, Thais S. Sabedot, Tathiane M. Malta, Lindsay Stetson, Olena Morozova, Artem Sokolov, Peter W. Laird, Maciej Wiznerowicz, Antonio Iavarone, Ja...> ;Cell Reports. 2018 Apr 10
986 citations
Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.
Katherine A Hoadley, Christina Yau, Toshinori Hinoue, Denise M. Wolf, Alexander J. Lazar, Esther Drill, Ronglai Shen, Alison M. Taylor, Andrew D. Cherniack, Vesteinn T...> ;Cell. 2018 Apr 5
76 citations
Efficacy of depatuxizumab mafodotin (ABT-414) monotherapy in patients with EGFR-amplified, recurrent glioblastoma: results from a multi-center, international study
Martin J. van den Bent, Hui K Gan, Andrew B. Lassman, Priya Kumthekar, Ryan Merrell, Nicholas Butowski, Zarnie Lwin, Tom Mikkelsen, Louis B. Nabors, Kyriakos P. Papado...> ;Cancer Chemotherapy and Pharmacology. 2017 Dec 1
10 citations
A parametric model of the brain vascular system for estimation of the arterial input function (AIF) at the tissue level.
Siamak P. Nejad-Davarani, Hassan Bagher-Ebadian, James R. Ewing, Douglas C. Noll, Tom Mikkelsen, Michael Chopp, Quan Jiang> ;NMR in Biomedicine. 2017 May 1
8 citations
An extended vascular model for less biased estimation of permeability parameters in DCE-T1 images.
Siamak P. Nejad-Davarani, Hassan Bagher-Ebadian, James R. Ewing, Douglas C. Noll, Tom Mikkelsen, Michael Chopp, Quan Jiang> ;NMR in Biomedicine. 2017 Feb 17
109 citations
Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis
Vijay Ramaswamy, Thomas Hielscher, Stephen C. Mack, Alvaro Lassaletta, Tong Lin, Kristian W. Pajtler, David T.W. Jones, Betty Luu, Florence M.G. Cavalli, Kenneth Aldap...> ;Journal of Clinical Oncology. 2016 Jul 20
16 citations
Combination of vatalanib and a 20-HETE synthesis inhibitor results in decreased tumor growth in an animal model of human glioma
Adarsh Shankar, Thaiz F. Borin, Asm Iskander, Nadimpalli Ravi S. Varma, Bhagelu R. Achyut, Meenu Jain, Tom Mikkelsen, Austin M. Guo, Wilson B. Chwang, James R. Ewing, ...> ;OncoTargets and Therapy. 2016 Mar 9
502 citations
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
Dominik Sturm, Brent A. Orr, Umut H. Toprak, Volker Hovestadt, David T.W. Jones, David Capper, Martin Sill, Ivo Buchhalter, Paul A. Northcott, Irina Leis, Marina Ryzho...> ;Cell. 2016 Feb 25
1195 citations
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.
Michele Ceccarelli, Floris P. Barthel, Tathiane M. Malta, Thais S. Sabedot, Sofie R. Salama, Bradley A. Murray, Olena Morozova, Yulia Newton, Amie Radenbaugh, Stefano ...> ;Cell. 2016 Jan 28
39 citations
A phase I study of cediranib in combination with cilengitide in patients with recurrent glioblastoma
Elizabeth R. Gerstner, Xiaobu Ye, Dan G. Duda, Michael A. Levine, Tom Mikkelsen, Thomas Kaley, Jeffrey J. Olson, Burt L. Nabors, Manmeet Ahluwalia, Patrick Y. Wen, Rak...> ;Neuro-oncology. 2015 Oct 1
33 citations
Identification of regions of normal grey matter and white matter from pathologic glioblastoma and necrosis in frozen sections using Raman imaging
Rachel E. Kast, Gregory W. Auner, Sally Yurgelevic, Brandy Broadbent, Aditya Raghunathan, Laila M. Poisson, Tom Mikkelsen, Mark L. Rosenblum, Steven N. Kalkanis> ;Journal of Neuro-oncology. 2015 Sep 10
23 citations
RTVP-1 promotes mesenchymal transformation of glioma via a STAT-3/IL-6-dependent positive feedback loop
Nis Giladi, Amotz Ziv-Av, Hae Kyung Lee, Susan Finniss, Simona Cazacu, Cunli Xiang, Hiba Waldman Ben-Asher, Ana C. deCarvalho, Tom Mikkelsen, Laila M. Poisson, Chaya B...> ;Oncotarget. 2015 Jul 20
20 citations
High-Throughput Screening of Patient-Derived Cultures Reveals Potential for Precision Medicine in Glioblastoma.
Christine E. Quartararo, Eduard Reznik, Ana C. deCarvalho, Tom Mikkelsen, Brent R. Stockwell> ;ACS Medicinal Chemistry Letters. 2015 Jun 22
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Hospital Affiliations

Henry Ford HospitalDetroit, Michigan
Henry Ford Wyandotte HospitalWyandotte, Michigan
Henry Ford West Bloomfield HospitalWest Bloomfield, Michigan

TommyMikkelsenMD

Dr. Mikkelsen is on Doximity

Education & Training

Certifications & Licensure

Awards, Honors, & Recognition

Clinical Trials

Publications & Presentations

Hospital Affiliations

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