UmaPrabhakarMD

PubMed

• 91 citations
  The anti-interleukin-6 antibody siltuximab down-regulates genes implicated in tumorigenesis in prostate cancer patients from a phase I study.
  Jayaprakash Karkera, Hannes Steiner, Weimin Li, Viktor Skradski, Patrizia Moser, Sabine Riethdorf, Manjula Reddy, Thomas A. Puchalski, Karim Safer, Uma Prabhakar, Klau...> ;The Prostate. 2011 Sep 15
• 48 citations
  Positive treatment effects of ustekinumab in psoriasis: Analysis of lesional and systemic parameters
  Manjula Reddy, Gisela Torres, Thomas S. McCormick, Colleen Marano, Kevin D. Cooper, Newman Yeilding, Y. Wang, Charles Pendley, Uma Prabhakar, Jackson Wong, Cuc Davis, ...> ;The Journal of Dermatology. 2010 May 1
• 78 citations
  Pharmacokinetic and pharmacodynamic modeling of an anti-interleukin-6 chimeric monoclonal antibody (siltuximab) in patients with metastatic renal cell carcinoma.
  Thomas A. Puchalski, Uma Prabhakar, Qun Jiao, Birge Berns, Hugh M. Davis> ;Clinical Cancer Research. 2010 Mar 1
• A phase I study of CNTO328, an anti-interleukin (IL)-6 monoclonal antibody combined with docetaxel in subjects with metastatic castration-resistant prostate cancer (CR...
  Hudes G, Tagawa S, Whang Y, Qi M, Qin X, Puchalski T, Prabhakar U, O'Brien K, Eisenberger M> ;J. Clin. Oncol.. 2009-05-20
• 44 citations
  The expression of monocyte chemotactic protein-1 in papillary thyroid carcinoma is correlated with lymph node metastasis and tumor recurrence.
  Katsuhiro Tanaka, Junichi Kurebayashi, Mai Sohda, Tsunehisa Nomura, Uma Prabhakar, Li Yan, Hiroshi Sonoo> ;Thyroid. 2009 Jan 2
• 77 citations
  Alpha-v integrins as therapeutic targets in oncology.
  Jeffrey A. Nemeth, Marian T Nakada, Mohit Trikha, Zhihui Lang, Michael S. Gordon, Gordon C Jayson, Robert Corringham, Uma Prabhakar, Hugh M. Davis, Robert A. Beckman> ;Cancer Investigation. 2007 Oct 1
• 50 citations
  Modulation of CLA, IL-12R, CD40L, and IL-2Rα expression and inhibition of IL-12- and IL-23-induced cytokine secretion by CNTO 1275
  Manjula Reddy, Cuc Davis, Jackson Wong, Paul Marsters, Charles Pendley, Uma Prabhakar> ;Cellular Immunology. 2007 May 1
• 112 citations
  Phase I Evaluation of a Fully Human Anti–αv Integrin Monoclonal Antibody (CNTO 95) in Patients with Advanced Solid Tumors
  Saifee Mullamitha, Nhuan C Ton, Geoff J M Parker, Alan Jackson, Peter J Julyan, Caleb Roberts, Giovanni A Buonaccorsi, Yvonne Watson, Karen Davies, Susan Cheung, Lynn ...> ;Clinical Cancer Research. 2007 Apr 1
• 42 citations
  Correlation of protein and gene expression profiles of inflammatory proteins after endotoxin challenge in human subjects.
  Uma Prabhakar, Theresa M. Conway, Paul R. Murdock, Jeff L. Mooney, Steve Clark, Priti Hedge, Brian C. Bond, Elizabeth C. Jazwinska, Michael R. Barnes, Frank L. Tobin, ...> ;DNA and Cell Biology. 2005 Jul 11
• 16 citations
  Reviews Preclinical Safety and Immune-Modulating Effects of Therapeutic Monoclonal Antibodies to Interleukin-6 and Tumor Necrosis Factor-alpha in Cynomolgus Macaques.
  Pauline L. Martin, Joel Cornacoff, Uma Prabhakar, Thomas Lohr, George Treacy, Jessica E. Sutherland, Sarah Hersey, Elise C. Martin> ;Journal of Immunotoxicology. 2005 Jul 1
• 8 citations
  Cutaneous lymphocyte antigen expression on activated lymphocytes and its association with IL-12R (β1 and β2), IL-2Rα, and CXCR3
  Manjula Reddy, Cuc Davis, Jackson Wong, Uma Prabhakar> ;Cellular Immunology. 2005 Jul 1
• 3 citations
  Co-expression of IL-12 receptors along with CXCR3 and CD25 on activated peripheral blood T lymphocytes.
  Manjula Reddy, Jackson Wong, Cuc Davis, Uma Prabhakar> ;Cellular Immunology. 2005 Jul 1
• 15 citations
  Multiplexed cytokine sandwich immunoassays: clinical applications.
  Uma Prabhakar, Edward Eirikis, Bruce E. Miller, Hugh M. Davis> ;Methods in Molecular Medicine. 2005 Jan 1
• 209 citations
  Comparative analysis of lymphocyte activation marker expression and cytokine secretion profile in stimulated human peripheral blood mononuclear cell cultures: an in vi...
  Manjula Reddy, Edward Eirikis, Cuc Davis, Hugh M. Davis, Uma Prabhakar> ;Journal of Immunological Methods. 2004 Oct 1
• 24 citations
  A pilot study on safety and pharmacokinetics of infliximab for the cancer anorexia/weight loss syndrome in non-small-cell lung cancer patients
  Aminah Jatoi, James R. Jett, Jeff A. Sloan, Paul J. Novotny, Joyce Ford, Uma Prabhakar, Charles L. Loprinzi> ;Supportive Care in Cancer. 2004 Sep 15
• 65 citations
  Validation and comparative analysis of a multiplexed assay for the simultaneous quantitative measurement of Th1/Th2 cytokines in human serum and human peripheral blood...
  Uma Prabhakar, Edward Eirikis, Manjula Reddy, Eva Silvestro, Susan Spitz, Charles Pendley, Hugh M. Davis, Bruce E. Miller> ;Journal of Immunological Methods. 2004 Aug 1
• 158 citations
  Simultaneous quantification of proinflammatory cytokines in human plasma using the LabMAP assay.
  Uma Prabhakar, Edward Eirikis, Hugh M Davis> ;Journal of Immunological Methods. 2002 Feb 1
• 110 citations
  SB 207499 (Ariflo), a Potent and Selective Second-Generation Phosphodiesterase 4 Inhibitor: In Vitro Anti-inflammatory Actions
  Mary S. Barnette, Siegfried B. Christensen, David M. Essayan, M Grous, Uma Prabhakar, Julia A. Rush, Anne Kagey-Sobotka, Theodore J. Torphy> ;The Journal of Pharmacology and Experimental Therapeutics. 1998 Jan 1
• 79 citations
  Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [3H]rolipra...
  M S Barnette, Bartus Jo, Burman M, Siegfried B. Christensen, L. B. Cieslinski, Esser Km, Prabhakar Us, Rush Ja, T J Torphy> ;Biochemical Pharmacology. 1996 Apr 12
• A multicenter, phase II study of infliximab plus gemcitabine in pancreatic cancer cachexia.
  Wiedenmann, B., Malfertheiner, P., Friess, H., Ritch, P., Arseneau, J., Mantovani, G., Caprioni, F., Van Cutsem, E., Richel, D., DeWitte, M., Qi, M., Robinson, D., Zho...> ;J Support Oncol. 2008 Jan
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