WajdAl-HolouMD

Neurosurgery • Ann Arbor, MI

Brain & Spinal Tumor

Physician

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Office
1500 E. Medical Center Drive
3552 Taubman Health Care Center
Ann Arbor, MI 48109
Phone+1 734-936-5015
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Education & Training

University of Texas M D Anderson Cancer CenterFellowship, Neurosurgical Oncology, 2016 - 2017
University of Michigan Health SystemResidency, Neurological Surgery, 2009 - 2016
University of Michigan Medical SchoolClass of 2009

Certifications & Licensure

MI State Medical License 2009 - 2025
TX State Medical License 2016 - 2018
American Board of Neurological Surgery Neurological Surgery

Publications & Presentations

PubMed

GTP Signaling Links Metabolism, DNA Repair, and Responses to Genotoxic Stress.
Zhou, W., Zhao, Z., Lin, A., Yang, J., Xu, J., Wilder-Romans, K., Yang, A., Li, J., Solanki, S., Speth, J., Walker, N., Scott, A., Wang, L., Wen, B., Andren, A., Zhang...> ;Cancer Discovery. 2024 Jan 12
A road map for the treatment of pediatric diffuse midline glioma.
Franson, A. (., Franson, A. (., Franson, A. (., Kilburn, L. B., Kilburn, L. B., Carl Koschmann, Wajd N Al-Holou, Marta M Alonso, Jamie Anastas, Pratiti Bandopadhayay, ...> ;Cancer Cell. 2024 Jan 8
7 citations
Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial.
Yoshie Umemura, Daniel Orringer, Larry Junck, Maria L Varela, Molly E J West, Syed M Faisal, Andrea Comba, Jason Heth, Oren Sagher, Denise Leung, Aaron Mammoser, Shawn...> ;The Lancet. Oncology. 2023 Sep 1
25 citations
Artificial-intelligence-based molecular classification of diffuse gliomas using rapid, label-free optical imaging.
Todd Hollon, Cheng Jiang, Asadur Chowdury, Mustafa Nasir-Moin, Akhil Kondepudi, Alexander Aabedi, Arjun Adapa, Wajd Al-Holou, Jason Heth, Oren Sagher, Pedro Lowenstein...> ;Nature Medicine. 2023 Apr 1
1 citations
Generation of 3D ex vivo mouse- and patient-derived glioma explant slice model for integration of confocal time-lapse imaging and spatial analysis.
Andrea Comba, Maria Luisa Varela, Syed M Faisal, Clifford C Abel 2nd, Anna E Argento, Wajd N Al-Holou, Todd C Hollon, Jacqueline D Perelman, Patrick J Dunn, Sebastien ...> ;STAR Protocols. 2023 Mar 16
2 citations
Metabolomic Profiles of Human Glioma Inform Patient Survival.
Andrew J Scott, Luis O Correa, Donna M Edwards, Yilun Sun, Visweswaran Ravikumar, Anthony C Andren, Li Zhang, Sudharsan Srinivasan, Neil Jairath, Kait Verbal, Karin Mu...> ;Antioxidants & Redox Signaling. 2023 Nov 1
1 citations
Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma.
Wajd N Al-Holou, Hanxiao Wang, Visweswaran Ravikumar, Sunita Shankar, Morgan Oneka, Ziad Fehmi, Roel Gw Verhaak, Hoon Kim, Drew Pratt, Sandra Camelo-Piragua, Corey Spe...> ;Neoplasia. 2023 Feb 1
11 citations
Spatiotemporal analysis of glioma heterogeneity reveals COL1A1 as an actionable target to disrupt tumor progression.
Andrea Comba, Syed M Faisal, Patrick J Dunn, Anna E Argento, Todd C Hollon, Wajd N Al-Holou, Maria Luisa Varela, Daniel B Zamler, Gunnar L Quass, Pierre F Apostolides,...> ;Nature Communications. 2022 Jun 24
3 citations
Circumferential sulcus-guided resection technique for improved outcomes of low-grade gliomas.
Wajd N Al-Holou, Dima Suki, Tiffany R Hodges, Richard G Everson, Jacob Freeman, Sherise D Ferguson, Ian E McCutcheon, Sujit S Prabhu, Jeffrey S Weinberg, Raymond Saway...> ;Journal of Neurosurgery. 2022 Jan 7
44 citations
G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy.
Mahmoud S. Alghamri, Brandon L. McClellan, Ruthvik Avvari, Rohit Thalla, Stephen Carney, Margaret S. Hartlage, Santiago Haase, Maria Ventosa, Ayman Taher, Neha Kamran,...> ;Science Advances. 2021 Sep 29
24 citations
Uncovering Spatiotemporal Heterogeneity of High-Grade Gliomas: From Disease Biology to Therapeutic Implications.
Andrea Comba, Syed M Faisal, Maria Luisa Varela, Todd C. Hollon, Wajd N. Al-Holou, Yoshie Umemura, Felipe J Nunez, Sebastien Motsch, Maria G. Castro, Pedro R. Lowenstein> ;Frontiers in Oncology. 2021 Aug 5
13 citations
Stem cells for the treatment of glioblastoma: a 20-year perspective.
Anda Alexandra Calinescu, McKenzie C. Kauss, Zain Sultan, Wajd N. Al-Holou, Sue O'Shea> ;CNS Oncology. 2021 May 19
14 citations
A validated integrated clinical and molecular glioblastoma long-term survival-predictive nomogram
Sherise D. Ferguson, Tiffany R Hodges, Nazanin Majd, Kristin Alfaro-Munoz, Wajd N. Al-Holou, Dima Suki, John de Groot, Gregory N. Fuller, Lee Xue, Miao Li, Carmen Jaco...> ;Neuro-Oncology Advances. 2021 Jan 1
16 citations
A Phase 2 Study of Dose-intensified Chemoradiation Using Biologically Based Target Volume Definition in Patients With Newly Diagnosed Glioblastoma
Michelle M. Kim, Yilun Sun, Madhava P. Aryal, Hemant Parmar, Morand Piert, B.S. Rosen, Charles S. Mayo, James M. Balter, Matthew J. Schipper, Nicolette Gabel, Emily M....> ;International Journal of Radiation Oncology, Biology, Physics. 2020 Nov 1
21 citations
Rapid, label-free detection of diffuse glioma recurrence using intraoperative stimulated Raman histology and deep neural networks.
Todd C. Hollon, Balaji Pandian, Esteban Urias, Akshay V. Save, Arjun R. Adapa, Sudharsan Srinivasan, Neil K. Jairath, Zia Farooq, Tamara Marie, Wajd N. Al-Holou, Karen...> ;Neuro-Oncology. 2021 Jan 30
2 citations
H3K27M-mutant diffuse midline glioma with extensive intratumoral microthrombi in a young adult with COVID-19-associated coagulopathy.
Matthew Pun, James Haggerty-Skeans, Drew Pratt, Yelena Fudym, Wajd N. Al-Holou, Sandra Camelo-Piragua, Sriram Venneti> ;Acta Neuropathologica. 2020 Jun 29
8 citations
Symptomatic CNS Radiation Necrosis Requiring Neurosurgical Resection During Treatment with Lorlatinib in ALK-Rearranged NSCLC: A Report of Two Cases
Viola W. Zhu, Misako Nagasaka, Takafumi Kubota, Kunil Raval, Natasha L. Robinette, Octavio Armas, Wajd N. Al-Holou, Sai-Hong Ignatius Ou> ;Lung Cancer. 2020 Jan 14
29 citations
Perilesional Resection of Glioblastoma Is Independently Associated With Improved Outcomes.
Wajd N. Al-Holou, Tiffany R. Hodges, Richard Everson, Jacob L. Freeman, Shouhao Zhou, Dima Suki, Ganesh Rao, Sherise D. Ferguson, Amy B. Heimberger, Ian E. McCutcheon,...> ;Neurosurgery. 2020 Jan 1
8 citations
Gastrostomy tube placement increases the risk of ventriculoperitoneal shunt infection: a multiinstitutional study.
Wajd N. Al-Holou, Thomas J. Wilson, Zarina S. Ali, Ryan P. Brennan, Kelly J. Bridges, Tannaz Guivatchian, Ghaith Habboub, Ajit A. Krishnaney, Giuseppe Lanzino, Kendall...> ;Journal of Neurosurgery. 2019 Oct 1
11 citations
Impact of early access to multidisciplinary care on treatment outcomes in patients with skull base chordoma
Jacob L. Freeman, Franco DeMonte, Wajd N. Al-Holou, Paul W. Gidley, Ehab Y. Hanna, Michael E. Kupferman, Shirley Y. Su, Shaan M. Raza> ;Acta Neurochirurgica. 2018 Apr 1
17 citations
A Novel Use of the Intraoperative MRI for Metastatic Spine Tumors: Laser Interstitial Thermal Therapy for Percutaneous Treatment of Epidural Metastatic Spine Disease
Jonathan G. Thomas, Wajd N. Al-Holou, Dhiego Chaves de Almeida Bastos, Amol J. Ghia, Jing Li, Andrew J. Bishop, Behrang Amini, Laurence D. Rhines, Claudio E. Tatsui> ;Neurosurgery Clinics of North America. 2017 Oct 1
9 citations
Is intensive care monitoring necessary after coil embolization of unruptured intracranial aneurysms
William R. Stetler, Julius Griauzde, Yamaan S Saadeh, Thomas J. Wilson, Wajd N. Al-Holou, Neeraj Chaudhary, B. Gregory Thompson, Aditya S. Pandey, Joseph J. Gemmete> ;Journal of Neurointerventional Surgery. 2017 Aug 1
5 citations
MRI-Guided Stereotactic Biopsy of Murine GBM for Spatiotemporal Molecular Genomic Assessment.
Stefanie Galbán, Wajd N. Al-Holou, Hanxiao Wang, Amanda R. Welton, Kevin A. Heist, Xin Kathy Hu, Roeland Verhaak, Yuan Zhu, Carlos Espinoza, Thomas L. Chenevert, B. A....> ;Tomography. 2017 Mar 1
15 citations
Comparison of the accuracy and proximal shunt failure rate of freehand placement versus intraoperative guidance in parietooccipital ventricular catheter placement.
Thomas J. Wilson, Kathleen E. McCoy, Wajd N. Al-Holou, Sergio L. Molina, Matthew D. Smyth, Stephen E. Sullivan> ;Neurosurgical Focus. 2016 Sep 1
15 citations
Morphometric analysis of the developing pediatric cervical spine.
Kyle T Johnson, Wajd N. Al-Holou, Richard C. E. Anderson, Thomas J. Wilson, Tejas Karnati, Mohannad Ibrahim, Hugh J. L. Garton, Cormac O. Maher> ;Journal of Neurosurgery. Pediatrics. 2016 May 27
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