WitoldBoleslawRybkaMD

Oncology • Hershey, PA

Hematologic Oncology

Professor, Medicine and Pathology, Pennsylvania State University College of Medicine

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Office
500 University Dr
Hershey, PA 17033
Phone+1 717-531-6601
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Education & Training

University of Toronto Faculty of MedicineClass of 1972

Certifications & Licensure

PA State Medical License 1991 - 2024
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Clinical Trials

Pentostatin, Cyclophosphamide, and Rituximab Followed By Campath-1H in Patients With Relapsed or Refractory B-Cell CLL Start of enrollment: 2005 Apr 14
Completed
Phase 2
Combination Chemotherapy and Alemtuzumab in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia Start of enrollment: 2006 Jun 01
Terminated
Phase 2
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Start of enrollment: 2008 Mar 12
Active, not recruiting
Phase 2
Fludarabine and Rituximab With or Without Lenalidomide or Cyclophosphamide in Treating Patients With Symptomatic Chronic Lymphocytic Leukemia Start of enrollment: 2008 Jan 15
Completed
Phase 2
Collecting Tissue Samples From Patients With Leukemia or Other Blood Disorders Planning to Enroll in an ECOG Leukemia Treatment Clinical Trial Start of enrollment: 2004 Sep 21
Completed
Stem Cell Related Donor Safety Study Start of enrollment: 2010 Jan 01
Completed
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) Start of enrollment: 2011 Oct 01
Recruiting
Trial of Eltrombopag During Consolidation Therapy in Adults With AML in Complete Remission Start of enrollment: 2012 Jul 01
Terminated
Phase 1, Phase 2
Rituximab and Combination Chemotherapy With or Without Lenalidomide in Treating Patients With Newly Diagnosed Stage II-IV Diffuse Large B Cell Lymphoma Start of enrollment: 2013 Aug 27
Active, not recruiting
Phase 2
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Publications & Presentations

PubMed

1 citations
The addition of doxycycline to fluoroquinolones for bacterial prophylaxis in autologous stem cell transplantation for multiple myeloma.
Emma G Guare, Cory M Hale, Jeffrey Sivik, Erik Lehman, Yoshika Inoue, Kevin Rakszawski, Natthapol Songdej, Myles Nickolich, Hong Zheng, Seema Naik, David Claxton, Wito...> ;Transplant Infectious Disease. 2024 Apr 1
1 citations
Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model.
Bei Jia, Kentaro Minagawa, Hiroko Shike, David F Claxton, W Christopher Ehmann, Witold B Rybka, Shin Mineishi, Ming Wang, Todd D Schell, K Sandeep Prabhu, Robert F Pau...> ;Journal of Immunology. 2023 Nov 1
Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide...
Joseph Cioccio, Kevin Rakszawski, Hong Zheng, Myles Nickolich, Seema Naik, Baldeep Wirk, Witold Rybka, Christopher Ehmann, Brooke Silar, Caitlin Vajdic, Neal Shah, Leo...> ;Annals of Hematology. 2023 Mar 1
1 citations
Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosp...
Neal Shah, Joseph Cioccio, Kevin Rakszawski, Hong Zheng, Myles Nickolich, Seema Naik, Baldeep Wirk, Witold Rybka, Christopher Ehmann, Brook Silar, Caitlin Vajdic, Jose...> ;Leukemia Research. 2022 Dec 1
Non-myeloablative allogeneic stem cell transplant with fludarabine and reduced dose cyclophosphamide in acute myeloid leukemia for older adults with comorbidities.
Christopher J Pizzola, Joseph Cioccio, Kevin L Rakszawski, Myles Nickolich, W Christopher Ehmann, Witold B Rybka, Baldeep Wirk, Seema Naik, Hong Zheng, Brooke Silar, H...> ;Bone Marrow Transplantation. 2022 Nov 1
17 citations
Post-transplant cyclophosphamide alters immune signatures and leads to impaired T cell reconstitution in allogeneic hematopoietic stem cell transplant.
Chenchen Zhao, Matthew Bartock, Bei Jia, Neal Shah, David F Claxton, Baldeep Wirk, Kevin L Rakszawski, Myles S Nickolich, Seema G Naik, Witold B Rybka, W Christopher C...> ;Journal of Hematology & Oncology. 2022 May 19
14 citations
Pembrolizumab plus dinaciclib in patients with hematologic malignancies: the phase 1b KEYNOTE-155 study.
Gregory, G., Kumar, S., Wang, D., Mahadevan, D., Walker, P., Wagner-Johnston, N., Escobar, C., Bannerji, R., Bhutani, D., Chang, J., Hernandez-Ilizaliturri, F., Klein,...> ;Blood Advances. 2022 Feb 22
2 citations
Tipifarnib as maintenance therapy did not improve disease-free survival in patients with acute myelogenous leukemia at high risk of relapse: Results of the phase III r...
Selina M. Luger, Victoria Wang, Jacob M. Rowe, Mark R. Litzow, Elisabeth Paietta, Rhett P. Ketterling, Hillard M. Lazarus, Witold B. Rybka, Michael Craig, Judith E. Ka...> ;Leukemia Research. 2021 Oct 28
1 citations
Improved outcome in AML relapse after allogeneic transplant with high-intensity chemotherapy followed by 2nd allogeneic stem cell transplant or donor lymphocyte infusion.
Neal Shah, Kevin Rakszawski, Myles Nickolich, Christopher Ehmann, Baldeep Wirk, Seema Naik, Witold B. Rybka, Hong Zheng, Joseph Mierski, Brooke Silar, Gina Mackey, Rob...> ;Annals of Hematology. 2021 Jul 29
5 citations
Impact of depth of clinical response on outcomes of acute myeloid leukemia patients in first complete remission who undergo allogeneic hematopoietic cell transplantation.
Mary-Elizabeth Percival, Hai-Lin Wang, Mei-Jie Zhang, Wael Saber, Marcos de Lima, Mark Litzow, Partow Kebriaei, Hisham Abdel-Azim, Kehinde Adekola, Mahmoud Aljurf, Ulr...> ;Bone Marrow Transplantation. 2021 Sep 1
16 citations
A phase I clinical trial of avelumab in combination with decitabine as first line treatment of unfit patients with acute myeloid leukemia.
Hong Zheng, Shin Mineishi, David F. Claxton, Junjia Zhu, Bei Jia, W. Christopher Ehmann, Witold B. Rybka, Seema Naik, Natthapol Songdej, Joseph J. Drabick, Raymond J. ...> ;American Journal of Hematology. 2021 Feb 1
Correction to: Impact of depth of clinical response on outcomes of acute myeloid leukemia patients in first complete remission who undergo allogeneic hematopoietic cel...
Mary Elizabeth Percival, Hai-Lin Wang, Mei-Jie Zhang, Wael Saber, Marcos de Lima, Mark R. Litzow, Partow Kebriaei, Hisham Abdel-Azim, Kehinde Adekola, Mahmoud Aljurf, ...> ;Bone Marrow Transplantation. 2021 Sep 1
1 citations
Unexpected Short-Tandem-Repeat Patterns in Posttransplant Chimerism Testing: Investigation of 3 Cases with Help from Forensic Science
Kristina Gvozdjan, Heather Casey, Carrie L. Mowery, Lorie H. Kumer, Carolyn Fisher, Jennifer Tyler, Mike G Bayerl, Jozef Malysz, Seema Naik, Witold B. Rybka, Christoph...> ;Laboratory Medicine. 2020 Nov 2
3 citations
A novel PrECOG (PrE0901) dose-escalation trial using eltrombopag: enhanced platelet recovery during consolidation therapy in acute myeloid leukemia.
Stephen A. Strickland, Xin Victoria Wang, Jan Cerny, Jacob M. Rowe, Witold B. Rybka, Martin S. Tallman, Mark R. Litzow, Hillard M. Lazarus> ;Leukemia & Lymphoma. 2020 May 30
10 citations
Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML.
Bei Jia, Ming Wang, Todd D. Schell, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Seema Naik, Natthapol Songdej, Jeff Sivik, Raymond J. Hohl...> ;British Journal of Haematology. 2020 Mar 1
34 citations
Eomes+T-betlow CD8+ T cells are functionally impaired and are associated with poor clinical outcome in patients with acute myeloid leukemia
Bei Jia, Kevin Rakszawski, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Ming Wang, Hiroko Shike, Michael G. Bayerl, Jeffrey Sivik, Todd D. ...> ;Cancer Research. 2019 Apr 1
26 citations
Characteristics of Late Fatal Infections after Allogeneic Hematopoietic Cell Transplantation
Maxim Norkin, Bronwen E. Shaw, Ruta Brazauskas, Heather R. Tecca, Helen Leather, Juan Gea-Banacloche, Rammurti T. Kamble, Zachariah DeFilipp, David A. Jacobsohn, Olle ...> ;Biology of Blood and Marrow Transplantation. 2019 Feb 1
20 citations
A randomized trial of three novel regimens for recurrent acute myeloid leukemia demonstrates the continuing challenge of treating this difficult disease.
Mark R. Litzow, Xin V. Wang, Martin Carroll, Judith E. Karp, Rhett P. Ketterling, Yanming Zhang, Scott H. Kaufmann, Hillard M. Lazarus, Selina M. Luger, Elisabeth Paie...> ;American Journal of Hematology. 2019 Jan 1
18 citations
Effect of Antihuman T Lymphocyte Globulin on Immune Recovery after Myeloablative Allogeneic Stem Cell Transplantation with Matched Unrelated Donors: Analysis of Immune...
Mahasweta Gooptu, Haesook T. Kim, Yi Bin Chen, Witold B. Rybka, Andrew S. Artz, Michael Boyer, Laura Johnston, Joseph P. McGuirk, Thomas C. Shea, Madan Jagasia, Paul J...> ;Biology of Blood and Marrow Transplantation. 2018 Nov 1
97 citations
VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML.
Liru Wang, Bei Jia, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Seema Naik, Muhammad Rizwanulhaq Khawaja, Jeff Sivik, Junyan Han, Raymond ...> ;Oncoimmunology. 2018 Jul 11
43 citations
Bone marrow CD8 T cells express high frequency of PD-1 and exhibit reduced anti-leukemia response in newly diagnosed AML patients.
Bei Jia, Liru Wang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Syed Rizvi, Hiroko Shike, Michael G. Bayerl, Todd D. Schell, Raymond J. Ho...> ;Blood Cancer Journal. 2018 Mar 21
196 citations
T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8+ T-Cell Exhaustion and Poor Clinical Outcome in AML Patients
Yaxian Kong, Liuluan Zhu, Todd D. Schell, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Melissa R. George, Hui Zeng, Hong Zheng> ;Clinical Cancer Research. 2016 Jun 15
195 citations
Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Pa...
Robert J. Soiffer, Haesook T. Kim, Joseph P. McGuirk, Mitchell E. Horwitz, Laura Johnston, Mrinal M. Patnaik, Witold B. Rybka, Andrew S. Artz, David L. Porter, Thomas ...> ;Journal of Clinical Oncology. 2017 Oct 17
39 citations
Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia
Liuluan Zhu, Yaxian Kong, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Neil Palmisiano, Ming Wang, Bei Jia, Michael G. Bayerl, Todd D. Sch...> ;Journal of Hematology & Oncology. 2017 Jun 19
8 citations
PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features
Emmanuel K. Teye, Abigail Sido, Ping Xin, Niklas Finnberg, Prashanth Gokare, Yuka Imamura Kawasawa, Anna C. Salzberg, Sara Shimko, Michael G. Bayerl, W. Christopher Eh...> ;Oncotarget. 2017 Feb 7
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