EdwardBLeeMD

PubMed

• 2 citations
  Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
  Celeste Parra Bravo, Alice Maria Giani, Jesus Madero Perez, Zeping Zhao, Yuansong Wan, Avi J Samelson, Man Ying Wong, Alessandro Evangelisti, Ethan Cordes, Li Fan, Pea...> ;Cell. 2024 Mar 28
• Ultrastructure of human brain tissue vitrified from autopsy revealed by cryo-ET with cryo-plasma FIB milling.
  Benjamin C Creekmore, Kathryn Kixmoeller, Ben E Black, Yi-Wei Chang, Edward B Lee> ;Nature Communications. 2024 Mar 26
• MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons.
  Hong Xu, Qi Qiu, Peng Hu, Kevt'her Hoxha, Elliot Jang, Mia O'Reilly, Christopher Kim, Zhuohao He, Nicholas Marotta, Lakshmi Changolkar, Bin Zhang, Hao Wu, Gerard D Sch...> ;Acta Neuropathologica. 2024 Mar 12
• Tau-neurodegeneration mismatch reveals vulnerability and resilience to comorbidities in Alzheimer's continuum.
  Xueying Lyu, Michael Tran Duong, Long Xie, Robin de Flores, Hayley Richardson, Gyujoon Hwang, Laura E M Wisse, Michael DiCalogero, Corey T McMillan, John L Robinson, S...> ;Alzheimer's & Dementia. 2024 Mar 1
• Association of Structural Forms of 17q21.31 with the Risk of Progressive Supranuclear Palsy andSub-haplotypes.
  Hui Wang, Timothy S Chang, Beth A Dombroski, Po-Liang Cheng, Ya-Qin Si, Albert Tucci, Vishakha Patil, Leopoldo Valiente-Banuet, Kurt Farrell, Catriona Mclean, Laura Mo...> ;Medrxiv. 2024 Feb 28
• Neighborhood disadvantage reduces cognitive reserve independent of neuropathologic change.
  Boram Kim, Isabel Yannatos, Kaitlin Blam, Douglas Wiebe, Sharon X Xie, Corey T McMillan, Dawn Mechanic-Hamilton, David A Wolk, Edward B Lee> ;Alzheimer's & Dementia. 2024 Feb 23
• Network Proteomics of the Lewy Body Dementia Brain Reveals Presynaptic Signatures Distinct from Alzheimer's Disease.
  Shantaraman, A., Dammer, E., Duong, D., Yin, L., Carter, E., Gearing, M., Trojanowski, J., Bennett, D., Seyfried, N., Ugochukwu, O., Chen-Plotkin, A., Lee, E., Lah, J....> ;Biorxiv. 2024 Jan 24
• Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease.
  Sanaz Arezoumandan, Katheryn A Q Cousins, Daniel T Ohm, MaKayla Lowe, Min Chen, James Gee, Jeffrey S Phillips, Corey T McMillan, Kelvin C Luk, Andres Deik, Meredith A ...> ;Annals of Clinical and Translational Neurology. 2024 Mar 1
• Proteomic Changes in the Human Cerebrovasculature in Alzheimer's Disease and Related Tauopathies Linked to Peripheral Biomarkers in Plasma and Cerebrospinal Fluid.
  Wojtas, A., Dammer, E., Guo, Q., Ping, L., Shantaraman, A., Duong, D., Yin, L., Fox, E., Seifar, F., Lee, E., Johnson, E., Lah, J., Levey, A., Levites, Y., Rangaraju, ...> ;Medrxiv. 2024 Jan 11
• 2 citations
  Inferring super-resolution tissue architecture by integrating spatial transcriptomics with histology.
  Daiwei Zhang, Amelia Schroeder, Hanying Yan, Haochen Yang, Jian Hu, Michelle Y Y Lee, Kyung S Cho, Katalin Susztak, George X Xu, Michael D Feldman, Edward B Lee, Emma ...> ;Nature Biotechnology. 2024 Jan 2
• Polypathologic Associations with Gray Matter Atrophy in Neurodegenerative Disease.
  Jeffrey S Phillips, John L Robinson, Katheryn A Q Cousins, David A Wolk, Edward B Lee, Corey T McMillan, John Q Trojanowski, Murray Grossman, David J Irwin> ;The Journal of Neuroscience. 2024 Feb 7
• 1 citations
  The neuropathology of intimate partner violence.
  Kristen Dams-O'Connor, Alan C Seifert, John F Crary, Bradley N Delman, Marc R Del Bigio, Gabor G Kovacs, Edward B Lee, Amber L Nolan, Ariel Pruyser, Enna Selmanovic, W...> ;Acta Neuropathologica. 2023 Dec 1
• 2 citations
  Risk of chronic traumatic encephalopathy in rugby union is associated with length of playing career.
  William Stewart, Michael E Buckland, Bobak Abdolmohammadi, Andrew J Affleck, Victor E Alvarez, Shannon Gilchrist, Bertrand R Huber, Edward B Lee, Donald M Lyall, Chris...> ;Acta Neuropathologica. 2023 Dec 1
• An autosomal-dominant childhood-onset disorder associated with pathogenic variants in VCP.
  Annelise Y Mah-Som, Jil Daw, Diana Huynh, Mengcheng Wu, Benjamin C Creekmore, William Burns, Steven A Skinner, Øystein L Holla, Marie F Smeland, Marc Planes, Kevin Ugu...> ;American Journal of Human Genetics. 2023 Nov 2
• Neurodegenerative Disease Tauopathies.
  Benjamin C Creekmore, Ryohei Watanabe, Edward B Lee> ;Annual Review of Pathology. 2024 Jan 24
• 1 citations
  C9orf72 proline-arginine dipeptide repeats disrupt the proteasome and perturb proteolytic activities.
  Yifan Zhang, Sophia C K Nelson, Ashley P Viera Ortiz, Edward B Lee, Robert Fairman> ;Journal of Neuropathology and Experimental Neurology. 2023 Oct 20
• Alzheimer Disease Biomarkers: Moving from CSF to Plasma for Reliable Detection of Amyloid and tau Pathology.
  Ju Hee Kang, Magdalena Korecka, Edward B Lee, Katheryn A Q Cousins, Thomas F Tropea, Alice A Chen-Plotkin, David J Irwin, David Wolk, Magdalena Brylska, Yang Wan, Lesl...> ;Clinical Chemistry. 2023 Nov 2
• 1 citations
  Native ultrastructure of fresh human brain vitrified directly from autopsy revealed by cryo-electron tomography with cryo-plasma focused ion beam milling.
  Benjamin C Creekmore, Kathryn Kixmoeller, Ben E Black, Edward B Lee, Yi-Wei Chang> ;Biorxiv. 2023 Sep 17
• 1 citations
  Detection of blood-brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2.
  Hailong Song, Alexandra Tomasevich, Kofi K Acheampong, Dylan L Schaff, Sydney M Shaffer, Jean-Pierre Dolle, Victoria E Johnson, Bailey Mikytuck, Edward B Lee, Amber No...> ;Acta Neuropathologica. 2023 Nov 1
• Correction: APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease.
  Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Lee> ;Acta Neuropathologica. 2023 Oct 1
• 7 citations
  Human Alzheimer's disease reactive astrocytes exhibit a loss of homeostastic gene expression.
  David L Dai, Mingyao Li, Edward B Lee> ;Acta Neuropathologica Communications. 2023 Aug 2
• 5 citations
  Leveraging spatial transcriptomics data to recover cell locations in single-cell RNA-seq with CeLEry.
  Qihuang Zhang, Shunzhou Jiang, Amelia Schroeder, Jian Hu, Kejie Li, Baohong Zhang, David Dai, Edward B Lee, Rui Xiao, Mingyao Li> ;Nature Communications. 2023 Jul 8
• 2 citations
  Cellular processing of α-synuclein fibrils results in distinct physiological C-terminal truncations with a major cleavage site at residue Glu 114.
  Stephan Quintin, Grace M Lloyd, Giavanna Paterno, Yuxing Xia, Zachary Sorrentino, Brach M Bell, Kimberly-Marie Gorion, Edward B Lee, Stefan Prokop, Benoit I Giasson> ;The Journal of Biological Chemistry. 2023 Jul 1
• 10 citations
  Deciphering tumor ecosystems at super resolution from spatial transcriptomics with TESLA.
  Jian Hu, Kyle Coleman, Daiwei Zhang, Edward B Lee, Humam Kadara, Linghua Wang, Mingyao Li> ;Cell Systems. 2023 May 17
• Creating the Pick's disease International Consortium: Association study ofH2 haplotype with risk of Pick's disease.
  White, C. L., White, C. L., Rebecca R Valentino, William J Scotton, Shanu F Roemer, Tammaryn Lashley, Michael G Heckman, Maryam Shoai, Alejandro Martinez-Carrasco, Nic...> ;Medrxiv. 2023 Apr 24
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Journal Articles

• Neurodegenerative Disease Concomitant Proteinopathies Are Prevalent, Age-Related and APOE4-Associated  
  David Wolk, Steven E Arnold, Edward B Lee, David J Irwin, Leo McCluskey, Howard I Hurtig, Lauren Elman, Bruce Miller, Murray Grossman, John E Duda, John Q Trojanowski,..., Brain