FrancisYLeeMD, Ph.D.

Musculoskeletal Oncology/Cancer, Pediatric Orthopedics

Professor of Orthopaedics & Rehabilitation with Tenure; Wayne O. Southwick Professor; Professor of Pathology, Secondary Appointment, Yale University School of Medicine

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Overview of Dr. Lee

Orthopaedic Oncology
Metastatic Bone Cancer
CT-Guided Procedure
Adult and Pediatric Orthopaedics
Infection
Complex Limb Reconstruction
Orthopaedic Research

Office
Yale Orthopaedics & Rehabilitation
260 Long Ridge Road
Stamford, CT 06902
Book by Phone+1(912) 666-2452
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Education & Training

Hospital for Sick Children, University of TorontoFellowship, Pediatric Orthopaedics, 1998 - 1999
Children's HospitalFellowship, Pediatric Orthopaedics, 1997 - 1998
Massachusetts General Hospital/Harvard Medical SchoolFellowship, Musculoskeletal Oncology, 1997 - 1998
Orthopedic CenterResidency, Orthopaedic Surgery, 1993 - 1997
Icahn School of Medicine at Mount SinaiOrthopaedic Research Fellowship, 1995 - 1996
Rutgers Health/New Jersey Medical SchoolResidency, Surgery, 1992 - 1993
Seoul National University COMClass of 1986

Certifications & Licensure

CT State Medical License 2016 - 2023
CA State Medical License 2015 - Present
NY State Medical License 1999 - 2018
NJ State Medical License 1996 - 2017

Awards, Honors, & Recognition

National Cancer Institute R01
National Institute of Arthritis Musculoskeletal Skin Disorders R01 Grant
NIAMS R01 Grant
American Academy of Orthopaedic Surgeons Kappa Delta Award 2016
NIBIB Research Grant Award NIH
Musculoskeletal Transplantation Foundation Award 2014-2016
Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012
Professor of Orthopaedic Surgery with Tenure Columbia University, New York, 2012
Department of Defense Research Grant Award DOD, 2010-2014
NIAMS R01 Research Award NIH, 2009-2018
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Publications & Presentations

PubMed

1 citations
Biocompatibility of platinum-based bulk metallic glass in orthopedic applications.
Ayomiposi M. Loye, Hyuk-Kwon Kwon, David Dellal, Rodrigo Ojeda, Sangmin Lee, Rose Davis, Natalie Nagle, Panagiotis G Doukas, Jan Schroers, Francis Y. Lee, Themis R. Ky...> ;Biomedical Materials. 2021 Apr 19
3 citations
Locally delivered adjuvant biofilm‐penetrating antibiotics rescue impaired endochondral fracture healing caused by MRSA infection
Sean V. Cahill, Hyuk-Kwon Kwon, Jung Ho Back, Inkyu Lee, Saelim Lee, Kareme D Alder, Zichen Hao, Kristin E. Yu, Christopher M. Dussik, Themis R. Kyriakides, Francis Y....> ;Journal of Orthopaedic Research. 2021 Feb 1
1 citations
Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Percutaneous Endoskeletal Reconstruction of Periacetabular and Other Periarticular Osteolytic Metastases.
Courtney Toombs, Devin Conway, Alana M. Munger, Kareme D Alder, Igor Latich, Francis Y. Lee> ;Journal of Bone and Joint Surgery, American Volume. 2021 Jan 1
3 citations
Smoking Alters Inflammation and Skeletal Stem and Progenitor Cell Activity During Fracture Healing in Different Murine Strains
Zichen Hao, Jun Li, Bo Li, Kareme D Alder, Sean V. Cahill, Alana M. Munger, Inkyu Lee, Hyuk-Kwon Kwon, Jung Ho Back, Shuogui Xu, Min-Jong Kang, Francis Y. Lee> ;Journal of Bone and Mineral Research. 2021 Jan 1
10 citations
Re-appraising the potential of naringin for natural, novel orthopedic biotherapies.
Kristin E. Yu, Kareme D Alder, Montana T Morris, Alana M. Munger, Inkyu Lee, Sean V. Cahill, Hyuk-Kwon Kwon, Jung Ho Back, Francis Y. Lee> ;Therapeutic Advances in Musculoskeletal Disease. 2020 Dec 8
Bone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus.
Andre M. Samuel, Alana M. Munger, Francis Y. Lee, Gary E. Friedlaender, Izuchukwu K Ibe, Dieter M. Lindskog> ;Orthopedics. 2020 Sep 3
16 citations
Intracellular Staphylococcus aureus in bone and joint infections: A mechanism of disease recurrence, inflammation, and bone and cartilage destruction.
Kareme D Alder, Inkyu Lee, Alana M. Munger, Hyuk-Kwon Kwon, Montana T Morris, Sean V. Cahill, Jung Ho Back, Kristin E. Yu, Francis Y. Lee> ;Bone. 2020 Jul 31
3 citations
Systemic Parathyroid Hormone Enhances Fracture Healing in Multiple Murine Models of Type 2 Diabetes Mellitus
Kareme D Alder, Andrew H. A. White, Yeon-Ho Chung, Inkyu Lee, Jung Ho Back, Hyuk-Kwon Kwon, Sean V. Cahill, Zichen Hao, Lu Li, Fancheng Chen, Saelim Lee, Matthew D. Ri...> ;JBMR plus. 2020 May 1
1 citations
Avoiding Limb-Length Discrepancy with Reconstruction of a Massive Tibial Defect Using a Bone Allograft and a Minimally Invasive Lengthening System in a Pediatric Patie...
Kareme D Alder, Montana T Morris, Zichen Hao, Lu Li, Kristin E. Yu, Francis Y. Lee> ;Journal of Bone and Joint Surgery, American Volume. 2020 Apr 1
12 citations
Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of W...
Francis Y. Lee, Igor Latich, Courtney Toombs, Alana Mungur, Devin Conway, Kareme D Alder, Izuchukwu K Ibe, Dieter M. Lindskog, Gary E. Friedlaender> ;Journal of Vascular and Interventional Radiology. 2020 Mar 3
10 citations
Recalcitrant methicillin-resistant Staphylococcus aureus infection of bone cells: Intracellular penetration and control strategies.
Kristin E. Yu, Lee Song, Hyunwoo P Kang, Hyuk-Kwon Kwon, Jung Ho Back, Francis Y. Lee> ;Bone and Joint Research. 2020 Feb 7
Rotational Tibio-Pelvic Constrained Hip Arthroplasty: A Surgical Technique: A Case Report.
Sean V. Cahill, Kristin E. Yu, Christopher M. Dussik, Francis Y. Lee> ;Journal of Bone and Joint Surgery, American Volume. 2019 Nov 7
14 citations
Bone Quality and Fracture-Healing in Type-1 and Type-2 Diabetes Mellitus
Shasta E Henderson, Izuchukwu K Ibe, Sean V. Cahill, Yeon-Ho Chung, Francis Y. Lee> ;Journal of Bone and Joint Surgery, American Volume. 2019 Aug 7
Excisional Curettage of Benign Cystic Lesions.
Izuchukwu K Ibe, Kareme D Alder, Shasta E Henderson, Kristin E Yu, Francis Y Lee> ;JBJS essential surgical techniques. 2019 Jul 10
A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice.
Kwon, H. K.,Patra, M. C.,Shin, H. J.,Gui, X.,Achek, A.,Panneerselvam, S.,Kim, D. J.,Song, S. J.,Hong, R.,Kim, K. S.,Kim, Y. G.,Lee, F. Y.,Hahm, D. H.,Lee, S. H.,Choi, S.> ;Exp. Mol. Med.. 2019 Apr 28
9 citations
Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone: A 1 to 12-Year Follow-up Study.
David D. Greenberg, Francis Y. Lee> ;American Journal of Clinical Oncology. 2019 Mar 1
Defining preoperative imaging findings of sacral chordomas associated with decreased overall survival and local recurrence.
Munger, A. M.,Geddes, B. J.,Lee, F. Y.> ;J Spine Surg. 2019 Apr 30
Femoral and Tibial Reconstruction for Skeletal Metastases and Pathologic Fractures.
Shasta E Henderson, Kristin E. Yu, Kareme D Alder, Izuchukwu K Ibe, Francis Y. Lee, Dieter M. Lindskog> ;Journal of Bone and Joint Surgery, American Volume. 2019 Jan 1
Pharmacologic and Radiation Therapies for Cancer-Induced Bone Loss.
Shasta E Henderson, Christopher M. Dussik, Jordan Brand, Izuchukwu K Ibe, Francis Y. Lee> ;Journal of Bone and Joint Surgery, American Volume. 2019 Jan 1
2 citations
Metastatic Cancers to Bone: An Overview and Cancer-Induced Bone Loss.
Izuchukwu K Ibe, Adam Sahlstrom, Andrew H. A. White, Shasta E Henderson, Francis Y. Lee> ;Journal of Bone and Joint Surgery, American Volume. 2019 Jan 1
10 citations
Calreticulin inhibits inflammation-induced osteoclastogenesis and bone resorption.
Charla R. Fischer, Maya Mikami, Hiroshi Minematsu, Saqib Nizami, Heon Goo Lee, Danielle K. Stamer, Neel Patel, Do Y. Soung, Jung Ho Back, Lee Song, Hicham Drissi, Fran...> ;Journal of Orthopaedic Research. 2017 Dec 1
Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic mice.
Mirza, F.,Lorenzo, J.,Drissi, H.,Lee, F. Y.,Soung, D. Y.> ;J. Nutr. Biochem.. 2017 Nov 18
35 citations
Tendon stem/progenitor cells regulate inflammation in tendon healing via JNK and STAT3 signaling
Solaiman Tarafder, Esther Chen, Yena Jun, Kristy Kao, Kun Hee Sim, Jung Ho Back, Francis Y. Lee, Chang H. Lee> ;The FASEB Journal. 2017 May 22
53 citations
Additive manufacturing of hydrogel-based materials for next-generation implantable medical devices
Sau Yin Chin, Yukkee C Poh, Anne-Céline Kohler, Jocelyn T. Compton, Lauren L. Hsu, Kathryn Mei Ming Lau, Sohyun Kim, Benjamin W. Lee, Francis Y. Lee, Samuel K. Sia> ;Science robotics. 2017 Jan 4
7 citations
Tissue engineering advances in spine surgery
Melvin C. Makhni, Jon-Michael E. Caldwell, Comron Saifi, Charla R. Fischer, Ronald A. Lehman, Lawrence G. Lenke, Francis Y. Lee> ;Regenerative Medicine. 2016 Feb 15
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Journal Articles

More than 100 articles on Orthopaedic Tumors, Pediatric Orthopaedics, and Musculoskeletal Science
Francis Y. Lee, M.D., Ph.D., Scientific Articles, 1/1/2014

Hospital Affiliations

Greenwich HospitalGreenwich, Connecticut