Frank A Sinicrope MD FACP
Gastrointestinal Cancer, Hepatology & Liver Transplantation
Professor, Internal Medicine and Oncology, Mayo Medical School
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200 1st St SwRochester, MN 55905
Phone+1 507-284-2511
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Education & Training
University of Texas Health Science Center at Houston/M D Anderson Cancer CenterFellowship, Hematology and Medical Oncology, 1996 - 1997
University of ChicagoFellowship, Gastroenterology, 1989 - 1992
Michael Reese Hospital and Medical CenterResidency, Internal Medicine, 1986 - 1988
University of Chicago Division of the Biological Sciences The Pritzker School of MedicineClass of 1985
Certifications & Licensure
CA State Medical License 1991 - Present
MN State Medical License 2002 - 2025
TX State Medical License 1992 - 2003
IL State Medical License 1985 - 1993
American Board of Internal Medicine Internal Medicine- American Board of Internal Medicine Gastroenterology
- American Board of Internal Medicine Medical Oncology
Clinical Trials
- Comparison of Combination Chemotherapy Regimens With or Without Cetuximab in Treating Patients Who Have Undergone Surgery For Stage III Colon Cancer Start of enrollment: 2004 Feb 01
- Neoadjuvant Celecoxib and Capecitabine Combined With Pelvic Irradiation in Treating Patients With Stage II or Stage III Adenocarcinoma (Cancer) of the Rectum Start of enrollment: 2004 Dec 01
- Acetylsalicylic Acid and Eflornithine in Treating Patients at High Risk for Colorectal Cancer Start of enrollment: 2009 Aug 20
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Publications & Presentations
PubMed
- Identification of Candidate Alterations Mediating KRASG12C Inhibitor Resistance in Advanced Colorectal and Pancreatic Cancers.Khalid Jazieh, Jill Tsai, Sheila Solomon, Mojun Zhu, Frank A Sinicrope
Clinical Cancer Research. 2025-03-03 - Esophageal Squamous Cell Carcinoma Causing Tracheal Invasion and Compression.John A Damianos, Krishan R Jethwa, Michael Camilleri, Frank A Sinicrope
Mayo Clinic Proceedings. 2025-03-01 - Spatially resolved, multi-region proteomics for prediction of immunotherapy outcome in deficient mismatch repair metastatic colorectal cancer.Bahar Saberzadeh-Ardestani, Zhenglong Liu, Mariam I Stein, Will A Sherman, Christy E Trussoni
Clinical Cancer Research. 2025-02-19
Journal Articles
- MiR-139-5p as a Novel Serum Biomarker for Recurrence and Metastasis in Colorectal CancerFrank A Sinicrope, Steven R Alberts, Ajay Goel, Nature
Lectures
- Relative contribution of clinical and molecular features to outcome within low and high risk T and N groups in stage III colon cancer (CC).2019 ASCO Annual Meeting - 6/1/2019
- Randomized trial of standard chemotherapy alone or combined with atezolizumab as adjuvant therapy for patients with stage III colon cancer and deficient mismatch repai...2019 ASCO Annual Meeting - 6/1/2019
- Validation of tumor infiltrating lymphocytes (TIL) and tumor budding as predictors of prognosis in patients with stage III colon cancers treated in a FOLFOX-based adju...2018 ASCO Annual Meeting - Chicago, Illinois - 06/3/2018
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Press Mentions
HMN 2025: How Specific Proteins Are Linked to Immunotherapy Resistance in Metastatic Colorectal CancerMarch 14th, 2025- Breakthrough Research by Mayo Clinic Uncovers Proteins Associated with Immunotherapy Resistance in Metastatic Colorectal CancerMarch 13th, 2025
- Proteins Identified as Key Players in Immunotherapy Resistance for Colorectal CancerMarch 12th, 2025
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Grant Support
- Translational Research In Colon Cancer Prevention &TreatmentNational Cancer Institute2009–2011
- Polyphenon E For The Chemoprevention Of Colorectal CancerNational Cancer Institute2008–2011
- Aberrant Crypt FOCI As A Biomarker For ChemopreventionNational Cancer Institute2006–2009
- Clinical Significance Of Apoptosis In Colon CancerNational Cancer Institute2004–2006
- Clinical Significance Of Apoptosis In Colon CancerNational Cancer Institute2003
- Beta-Catenin And RAR Interact At The PKC Alpha PromoterNational Institute Of Diabetes And Digestive And Kidney Diseases2002
- A Three Arm Phase II Chemoprevention Trial In AdenomatouDivision Of Cancer Prevention And Control1999–2000
- Calcium And Aspirin Prevention TrialNational Cancer Institute1997
Professional Memberships
- Member
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