JamesJ DHsiehMD

PubMed

• Author Correction: Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma.
  Yige Wu, Nadezhda V Terekhanova, Wagma Caravan, Nataly Naser Al Deen, Preet Lal, Siqi Chen, Chia-Kuei Mo, Song Cao, Yize Li, Alla Karpova, Ruiyang Liu, Yanyan Zhao, An...> ;Nature Communications. 2023 May 17
• 11 citations
  Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma.
  Yige Wu, Nadezhda V Terekhanova, Wagma Caravan, Nataly Naser Al Deen, Preet Lal, Siqi Chen, Chia-Kuei Mo, Song Cao, Yize Li, Alla Karpova, Ruiyang Liu, Yanyan Zhao, An...> ;Nature Communications. 2023 Mar 27
• 3 citations
  SETD2 regulates chromatin accessibility and transcription to suppress lung tumorigenesis.
  Yuchen Xie, Merve Sahin, Toru Wakamatsu, Akane Inoue-Yamauchi, Wanming Zhao, Song Han, Amrita M Nargund, Shaoyuan Yang, Yang Lyu, James J Hsieh, Christina S Leslie, Em...> ;JCI Insight. 2023 Feb 22
• 38 citations
  Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer.
  Briana G Nixon, Fengshen Kuo, LiangLiang Ji, Ming Liu, Kristelle Capistrano, Mytrang Do, Ruth A Franklin, Xiaodi Wu, Emily R Kansler, Raghvendra M Srivastava, Tanaya A...> ;Immunity. 2022 Nov 8
• 7 citations
  Multiregional single-cell proteogenomic analysis of ccRCC reveals cytokine drivers of intratumor spatial heterogeneity.
  Natalia Miheecheva, Ekaterina Postovalova, Yang Lyu, Akshaya Ramachandran, Alexander Bagaev, Viktor Svekolkin, Ilia Galkin, Vladimir Zyrin, Vladislav Maximov, Yaroslav...> ;Cell Reports. 2022 Aug 16
• 31 citations
  Precise reconstruction of the TME using bulk RNA-seq and a machine learning algorithm trained on artificial transcriptomes.
  Aleksandr Zaitsev, Maksim Chelushkin, Daniiar Dyikanov, Ilya Cheremushkin, Boris Shpak, Krystle Nomie, Vladimir Zyrin, Ekaterina Nuzhdina, Yaroslav Lozinsky, Anastasia...> ;Cancer Cell. 2022 Aug 8
• 22 citations
  Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial.
  Chung-Han Lee, Robert Motzer, Hamid Emamekhoo, Marc Matrana, Ivor Percent, James J Hsieh, Arif Hussain, Ulka Vaishampayan, Sandy Liu, Steven McCune, Vijay Patel, Monta...> ;Clinical Cancer Research. 2022 Aug 2
• 23 citations
  SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes.
  Yuchen Xie, Merve Sahin, Sonali Sinha, Yufeng Wang, Amrita M Nargund, Yang Lyu, Song Han, Yiyu Dong, James J Hsieh, Christina S Leslie, Emily H Cheng> ;Nature Cancer. 2022 Feb 1
• 54 citations
  Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis.
  Kosuke Tanaka, Helena A. Yu, Shaoyuan Yang, Song Han, S. Duygu Selcuklu, Kwanghee Kim, Shriram Ramani, Yogesh Tengarai Ganesan, Allison Moyer, Sonali Sinha, Yuchen Xie...> ;Cancer Cell. 2021 Sep 13
• Diagnostic Utility of RNA-Seq for Evaluation of PD-L1 Expression in Clear Cell Renal Cell Carcinoma.
  Maria Sorokina, Danil Stupichev, Yang Lyu, Akshaya Ramachandran, Natalia Miheecheva, Jessica H. Brown, Krystle Nomie, Ekaterina Postovalova, Alexander Bagaev, Maria Ts...> ;Clinical Genitourinary Cancer. 2021 Jul 10
• 1 citations
  Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA
  Hidetaka Niizuma, Adam C. Searleman, Shugaku Takeda, Scott A. Armstrong, Christopher Y. Park, Emily H. Cheng, James J. Hsieh> ;JCI Insight. 2021 Aug 9
• 80 citations
  Lenvatinib plus pembrolizumab in patients with either treatment-naive or previously treated metastatic renal cell carcinoma (Study 111/KEYNOTE-146): a phase 1b/2 study.
  Chung-Han Lee, Amishi Yogesh Shah, Drew W. Rasco, Arpit Rao, Matthew H. Taylor, Christopher Di Simone, James J. Hsieh, Alvaro Pinto, David R. Shaffer, Regina Gironés S...> ;The Lancet. Oncology. 2021 Jul 1
• Resource-efficient pooled sequencing expands translational impact in solid tumors.
  Renzo G. DiNatale, Roy Mano, Vladimir Makarov, Nicole Rusk, Esther Drill, Andrew G. Winer, Alexander Sankin, Angela Yoo, Benjamin A Freeman, James J. Hsieh, Ying-Bei C...> ;Kidney Cancer Journal. 2021 Jun 1
• 35 citations
  A Single-arm, Multicenter, Phase 2 Study of Lenvatinib Plus Everolimus in Patients with Advanced Non-Clear Cell Renal Cell Carcinoma.
  Thomas E. Hutson, M. Dror Michaelson, Timothy M. Kuzel, Neeraj Agarwal, Ana M. Molina, James J. Hsieh, Ulka N. Vaishampayan, Ran Xie, Urmi Bapat, Weifei Ye, Rohit Jain...> ;European Urology. 2021 Apr 16
• The 2021 Variant Histology Issue.
  James J. Hsieh> ;Clinical Genitourinary Cancer. 2021 Apr 1
• 4 citations
  Structural insights into the function of the catalytically active human Taspase1
  Nirupa Nagaratnam, Silvia Delker, Rebecca Jernigan, Thomas E. Edwards, Janey Snider, Darren Thifault, Dewight Williams, Brent L. Nannenga, Mary Stofega, Lidia Sambucet...> ;Structure. 2021 Aug 5
• 11 citations
  Single-cell Spatial Proteomic Revelations on the Multiparametric MRI Heterogeneity of Clinically Significant Prostate Cancer.
  Russell K. Pachynski, Eric H. Kim, Natalia Miheecheva, Nikita Kotlov, Akshaya Ramachandran, Ekaterina Postovalova, Ilia Galkin, Viktor Svekolkin, Yang Lyu, Qiong Zou, ...> ;Clinical Cancer Research. 2021 Mar 26
• 752 citations
  Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma.
  Toni K. Choueiri, Thomas Powles, Mauricio Burotto, Bernard Escudier, Maria T Bourlon, B. Zurawski, Victor M. Oyervides Juárez, James J. Hsieh, Umberto Basso, Amishi Yo...> ;The New England Journal of Medicine. 2021 Mar 4
• The 2021 COVID-19 Artificial Intelligence Issue.
  James J. Hsieh> ;Clinical Genitourinary Cancer. 2021 Feb 1
• 1 citations
  The 2020 nccRCC Immunotherapy Issue
  James J. Hsieh> ;Clinical Genitourinary Cancer. 2020 Dec 1
• 2 citations
  Laparoscopic cytoreductive nephrectomy is associated with significantly improved survival compared with open cytoreductive nephrectomy or targeted therapy alone.
  Kaidong Zhao, Eric H. Kim, Joel Vetter, James J. Hsieh, Ramakrishna Venkatesh, Sam B. Bhayani, R. Sherburne Figenshau> ;Molecular and Clinical Oncology. 2020 Dec 1
• 87 citations
  TGF-β suppresses type 2 immunity to cancer.
  Ming Liu, Fengshen Kuo, Kristelle J. Capistrano, Davina Kang, Briana G. Nixon, Wei Shi, Chun Chou, Mytrang H. Do, Efstathios G. Stamatiades, Shengyu Gao, Shun Li, Ying...> ;Nature. 2020 Oct 21
• The 2020 Prostate Cancer Issue.
  James J. Hsieh> ;Clinical Genitourinary Cancer. 2020 Oct 1
• 1 citations
  The Pan-Omics Landscape of Renal Cell Carcinoma and Its Implication on Future Clinical Practice.
  Jennifer J. Huang, James J. Hsieh> ;Kidney Cancer. 2020 Sep 16
• 5 citations
  Targeting Metabolic Pathways in Kidney Cancer: Rationale and Therapeutic Opportunities.
  Christian R. Hoerner, Susanna Y. Miao, James J. Hsieh, Alice C. Fan> ;Cancer Journal. 2020 Sep 1
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Journal Articles

• Hyperpolarized MRI Visualizes Warburg Effects and Predicts Treatment Response to mTOR Inhibitors in Patient-Derived ccRCC Xenograft Models  
  James Hsieh, MD, Clinical Cancer Research
• Analysis of Renal Cancer Cell Lines from Two Major Resources Enables Genomics-Guided Cell Line Selection  
  Satish K Tickoo, Paul Russo, A Ari Hakimi, Victor E Reuter, James J Hsieh, Jonathan A Coleman, Michael Chevinsky, Christopher Jakubowski, Andrew G Winer, Nature
• Efficacy Genomic Biomarkers of a Randomized Trial Comparing First-Line Everolimus and Sunitinib in Patients with Metastatic Renal Cell Carcinoma  
  Hsieh JJ, David Chen, Patricia I. Wang, Mahtab Marker, Almedina Redzematovic, Ying-Bei Chen, S. Duygu Selcuklu, Nils Weinhold, Nancy Bouvier, Kety H. Huberman, Umesh B..., Eur Urol, 1/14/2016
• Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets associated with varying clinical outcomes  
  Chen Y, Xu J, Skanderup, AJ, Dong Y, Brannon AR, Wang L, Won WH, Wang PI, Nanjangud GJ, Jungbluth AA, Li W, Ojeda V, Hakimi AA, Voss MH, Schultz N, Motzer RJ, Russo P,..., Nat Comm, 1/1/2016
• A braided cancer river connects tumor heterogeneity and precision medicine  
  Hsieh JJ, Cheng EH, Clinical and Translational Medicine, 1/1/2016
• The Panoramic View of Clear Cell Renal Cell Carcinoma Metabolism: Values of Integrated Global Cancer Metabolomics  
  Hsieh JJ, Cheng EH, Trans Andro Urol, 1/1/2016
• Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant mRNA signatures  
  Senbabaoglu Y, Gejman RS, Winer AG, Liu M, Van Allen EM, de Velasco G, Miao D, Ostrovnaya I, Drill E, Luna A, Weinhold N, Lee W, Manley B, Khalil DN, Kaffenberger SD, ..., Genome Biology, 1/1/2016
• Modeling Tumor Growth for Kidney Cancer Based on Nuclei Clusters of Pathology Slides  
  Saribudak A, Dong Y, Hsieh JJ, Uyar MU, Inter J Engineering and Technology, 1/1/2016
• Tumor Xenografts of Human Clear Cell Renal Cell Carcinoma but not Corresponding Cell Lines Recapitulate Clinical Response to Sunitinib: Feasibility of Using Biopsy Sam...  
  Dong Y, Manley BJ, Becerra MF, Redzematovid A, Casuscelli J, Tennebaum DM, Reznik E, Han S, Benfante N, Chen Y, Arcia ME, Aras O, Voss MH, Feldman DR, Motzer RJ, Fabbr..., Eur Urol Focus, 1/1/2016
• Integration of recurrent somatic mutations with clinical outcomes: a pooled analysis of 1049 clear cell renal cell carcinoma patients  
  Manley BJ, Zabor EC, Casuscelli J, Tennenbaum DM, Redzematovic A, Becerra MF, Benfante N, Sato Y, Morikawa T, Kume H, Fukayama M, Homma Y, Ogawa S, Arcila ME, Voss MH,..., Eur Urol Focus, 1/1/2016
• Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components  
  Manley BJ, Hsieh JJ, Transl Caner Res, 1/1/2016
• ClearCode34: A Prognostic Risk Predictor for Localized Clear Cell Renal Cell Carcinoma  
  Brooks SA, Brannon AR, Parker JS, Fisher JC, Sen O, Kattan MW, Hakimi AA, Hsieh JJ, Choueiri TK, Tamboli P, Maranchie JK, Hinds P, Miller CR, Nielsen ME, Rathmell WK, Eur Urol, 1/25/2014
• Tumor Genetic Analyses of Patients with Metastatic Renal Cell Carcinoma and Extended Benefit from mTOR Inhibitor Therapy  
  Voss MH, Hakimi AA, Pham CG, Brannon AR, Chen YB, Cunha LF, Akin O, Liu H, Takeda S, Scott SN, Socci ND, Viale A, Schultz N, Sander C, Reuter VE, Russo P, Cheng EH, Mo..., Clin Cancer Res, 1/1/2014
• A systematic review of predictive and prognostic biomarkers for VEGF-targeted therapy in renal cell carcinoma  
  Funakoshi T, Lee CH, Hsieh JJ, Cancer Treat Rev, 1/1/2014
• Radiogenomics of clear-cell renal cell carcinoma: Associations between CT imaging features and mutations  
  Karlo CA, Di Paolo PL, Chaim J, Hakimi AA, Ostrovnaya I, Russo P, Motzer RJ, Hricak H, Tickoo SK, Reuter VE, Hsieh JJ, Akin O, Radiology, 1/12/2013
• Adverse Outcomes in Clear Cell Renal Cell Carcinoma with Mutations of 3p21 Epigenetic Regulators BAP1 and SETD2: a Report by MSKCC and the KIRC TCGA Research Network  
  Hakimi AA, Ostrovnaya I, Reva B, Schultz N, Chen Y, Gonen M, Liu H, Takeda S, Voss MH, Tickoo SK, Reuter VE, Russo P, Cheng EH, Sander C, Motzer RJ, Hsieh JJ for The c..., Clin Can Res, 1/1/2013
• An Epidemiologic and Genomic Investigation into the Obesity Paradox in Clear Cell Renal Cell Carcinoma  
  Hakimi AA, Furberg H, Zabor EC, Jacobsen A, Schultz N, Ciriello G, Mikklineni N, Fiegoli B, Kim PH, Voss MH, Shen H, Laird PW, Sander C, Reuter VE, Motzer RJ, Hsieh JJ..., JNCI, 1/1/2013
• Comprehensive Molecular Characterization of clear cell renal cell carcinoma  
  The Cancer Genome Atlas Research Network* (Hsieh JJ), Nature, 1/1/2013
• Clear Picture of Renal Cell Carcinoma  
  Hakimi AA, Pham CG, Hsieh JJ, Nature Genetics, 1/1/2013
• Clinical and Pathologic Impact of Select Chromatin Modulating Tumor Suppressors in Clear Cell Renal Cell Carcinoma  
  Hakimi A, Chen Y, Wren J, Gonen M, Abdel-Wahab O, Heguy A, Liu H, Takeda S, Tickoo SK, Reuter VE, Voss MH, Motzer RJ, Coleman JA, Cheng EH, Russo P, Hsieh JJ, Eur Urol, 1/27/2012
• Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer  
  Vanharanta S, Shu W, Brenet F, Hakimi AA, Heguy A, Viale A, Reuter VE, Hsieh JJ, Scandura JM, Massague J, Nat Med, 1/9/2012
• A Pharmacologic Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth  
  Chen DY, Lee Y, Van Tine BA, Searleman AC, Westergard TD, Liu H, Tu HC, Takeda S, Dong Y, Piwnica-Worms DR, Oh KJ, Korsmeyer SJ, Hermone A, Gussio R, Shoemaker RH, Che..., Cancer Research, 1/1/2012
• Taspase1 Functions as a Non-oncogene Addiction Protease that Coordinates Cancer Cell Proliferation and Apoptosis  
  Chen D.Y., Liu H., Takeda S., Tu H., Sasagawa S, Van Tine B., Lu D., Cheng E.H.-Y., Hsieh JJ, Cancer Research, 1/1/2010
• Phosphorylation of MLL by ATR is Required for Execution of Mammalian S Phase Checkpoint  
  Liu H., Takeda S., Kumar R., Westergard T.D., Brown E.J., Pandita T., Cheng E.H.-Y., Hsieh JJ, Nature, 1/1/2010
• MLL5 Governs Hematopoiesis  
  Liu H., Westergard T.D., Hsieh JJ, Blood, 1/1/2009
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Books/Book Chapters

• Renal Cell Carcinoma: Molecular Targets and Clinical Applications 
  Chapter: PBRM1: A Critical Subunit of the SWI/SNF Chromatin Redmodeling Complex. 
  Lee CH, Pham CG, Hsieh JJEdition 3rd,2015
• Handbook of Proteolytic Enzymes. 
  Chapter: Taspase1. 
  Cunha L, Tong L, Hsieh JJEditors: Neil D. Rawlings, Guy Salvesen.2013