JoshuaKSabariMD

PubMed

• Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer.
  Rona Yaeger, Nataliya V Uboha, Meredith S Pelster, Tanios S Bekaii-Saab, Minal Barve, Joel Saltzman, Joshua K Sabari, Julio A Peguero, Andrew Scott Paulson, Pasi A Jän...> ;Cancer Discovery. 2024 Apr 8
• Safety and Intracranial Activity of Adagrasib in Patients With-Mutated Non-Small-Cell Lung Cancer and Untreated CNS Metastases in the KRYSTAL-1 Trial: A Case Series.
  Bernstein, E., Wang, K., Jänne, P., Luo, J., Negrao, M., Sabari, J.> ;JCO Precision Oncology. 2024 Feb 1
• Combinatorial therapy is a safe and durable treatment option in-rearranged non-small cell lung cancer with an acquiredexon 14 skipping mutation mediated resistance to ...
  Jang, C., Sabari, J.> ;Translational Lung Cancer Research. 2023 Dec 26
• 1 citations
  Selective Personalized RadioImmunotherapy for Locally Advanced Non-Small-Cell Lung Cancer Trial (SPRINT).
  Nitin Ohri, Shruti Jolly, Benjamin T Cooper, Rafi Kabarriti, William R Bodner, Jonathan Klein, Chandan Guha, Shankar Viswanathan, Elaine Shum, Joshua K Sabari, Haiying...> ;Journal of Clinical Oncology. 2024 Feb 10
• Matching-adjusted indirect comparison of amivantamab vs mobocertinib in platinum-pretreatedExon 20 insertion-mutated non-small-cell lung cancer.
  Tae Min Kim, Nicolas Girard, Natasha B Leighl, Joshua Sabari, Nora Rahhali, Claudio A Schioppa, Joris Diels, Jan Sermon, Conor Chandler, Venediktos Kapetanakis, Ruhee ...> ;Future Oncology. 2024 Mar 1
• 10 citations
  Amivantamab plus lazertinib in osimertinib-relapsed EGFR-mutant advanced non-small cell lung cancer: a phase 1 trial.
  Byoung Chul Cho, Dong-Wan Kim, Alexander I Spira, Jorge E Gomez, Eric B Haura, Sang-We Kim, Rachel E Sanborn, Eun Kyung Cho, Ki Hyeong Lee, Anna Minchom, Jong-Seok Lee...> ;Nature Medicine. 2023 Oct 1
• 6 citations
  Intracranial Efficacy of Adagrasib in Patients From the KRYSTAL-1 Trial With-Mutated Non-Small-Cell Lung Cancer Who Have Untreated CNS Metastases.
  Marcelo V Negrao, Alexander I Spira, Rebecca S Heist, Pasi A Jänne, Jose M Pacheco, Jared Weiss, Shirish M Gadgeel, Karen Velastegui, Wenjing Yang, Hirak Der-Torossian...> ;Journal of Clinical Oncology. 2023 Oct 1
• 6 citations
  Clinical and Genomic Features of Response and Toxicity to Sotorasib in a Real-World Cohort of Patients With Advanced-Mutant Non-Small Cell Lung Cancer.
  Rohit Thummalapalli, Ezra Bernstein, Benjamin Herzberg, Bob T Li, Afsheen Iqbal, Isabel Preeshagul, Fernando C Santini, Juliana Eng, Marc Ladanyi, Soo-Ryum Yang, Rongl...> ;JCO Precision Oncology. 2023 Jun 1
• 19 citations
  Adagrasib in Advanced Solid Tumors Harboring aMutation.
  Tanios S Bekaii-Saab, Rona Yaeger, Alexander I Spira, Meredith S Pelster, Joshua K Sabari, Navid Hafez, Minal Barve, Karen Velastegui, Xiaohong Yan, Aditya Shetty, Hir...> ;Journal of Clinical Oncology. 2023 Sep 1
• Seeing Beyond the Smoke: Reclassifying Lung Cancer by Smoking-Related Mutational Signatures.
  Joshua K Sabari, Moreira, A.> ;Journal of Thoracic Oncology. 2023 Apr 1
• 5 citations
  Management of infusion-related reactions (IRRs) in patients receiving amivantamab in the CHRYSALIS study.
  Keunchil Park, Joshua K Sabari, Eric B Haura, Catherine A Shu, Alexander Spira, Ravi Salgia, Karen L Reckamp, Rachel E Sanborn, Ramaswamy Govindan, Joshua M Bauml, Jos...> ;Lung Cancer. 2023 Apr 1
• 2 citations
  Extended Survival in Patients With Non-Small-Cell Lung Cancer-Associated Brain Metastases in the Modern Era.
  Assaf Berger, Reed Mullen, Kenneth Bernstein, Juan Diego Alzate, Joshua S Silverman, Erik P Sulman, Bernadine R Donahue, Abraham Chachoua, Elaine Shum, Vamsidhar Velch...> ;Neurosurgery. 2023 Jul 1
• 13 citations
  Amivantamab, an Epidermal Growth Factor Receptor (EGFR) and Mesenchymal-epithelial Transition Factor (MET) Bispecific Antibody, Designed to Enable Multiple Mechanisms ...
  Byoung Chul Cho, Allison Simi, Joshua Sabari, Smruthi Vijayaraghavan, Sheri Moores, Alexander Spira> ;Clinical Lung Cancer. 2023 Mar 1
• 90 citations
  First-in-Human Phase I/IB Dose-Finding Study of Adagrasib (MRTX849) in Patients With AdvancedSolid Tumors (KRYSTAL-1).
  Sai-Hong Ignatius Ou, Pasi A Jänne, Ticiana A Leal, Igor I Rybkin, Joshua K Sabari, Minal A Barve, Lyudmila Bazhenova, Melissa L Johnson, Karen L Velastegui, Cornelius...> ;Journal of Clinical Oncology. 2022 Aug 10
• 36 citations
  Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data from Patients with KRASG12C-Mutant Non-Small Cell Lung Cancer.
  Joshua K Sabari, Vamsidhar Velcheti, Kazuhide Shimizu, Matthew R Strickland, Rebecca S Heist, Mohini Singh, Naema Nayyar, Anita Giobbie-Hurder, Subba R Digumarthy, Jus...> ;Clinical Cancer Research. 2022 Aug 2
• 189 citations
  Adagrasib in Non-Small-Cell Lung Cancer Harboring aMutation.
  Pasi A Jänne, Gregory J Riely, Shirish M Gadgeel, Rebecca S Heist, Sai-Hong I Ou, Jose M Pacheco, Melissa L Johnson, Joshua K Sabari, Konstantinos Leventakos, Edwin Ya...> ;The New England Journal of Medicine. 2022 Jul 14
• 1 citations
  The incidence and predictors of new brain metastases in patients with non-small cell lung cancer following discontinuation of systemic therapy.
  Dennis London, Dev N Patel, Bernadine Donahue, Ralph E Navarro, Jason Gurewitz, Joshua S Silverman, Erik Sulman, Kenneth Bernstein, Amy Palermo, John G Golfinos, Joshu...> ;Journal of Neurosurgery. 2021 Dec 10
• 3 citations
  Hitting the Right Spot: Advances in the Treatment of NSCLC With Uncommon EGFR Mutations.
  Joshua K Sabari, John V Heymach, Beth Sandy> ;Journal of the National Comprehensive Cancer Network. 2021 Dec 1
• 1 citations
  Presentation, Diagnosis and Management of Innominate Artery Thromboembolism.
  Heepeel Chang, Caron B. Rockman, Navneet Narula, Joshua K. Sabari, Karan Garg> ;Journal of Endovascular Therapy. 2021 Oct 27
• 20 citations
  Comparison of solid tissue sequencing and liquid biopsy accuracy in identification of clinically relevant gene mutations and rearrangements in lung adenocarcinomas.
  Lawrence Hsu Lin, Douglas H R Allison, Yang Feng, George Jour, Kyung En Park, Fang Zhou, Andre L. Moreira, Guomiao Shen, Xiaojun Feng, Joshua K. Sabari, Vamsidhar Velc...> ;Modern Pathology. 2021 Aug 6
• 240 citations
  Amivantamab in EGFR exon 20 insertion-mutated non-small-cell lung cancer progressing on platinum chemotherapy: initial results from the CHRYSALIS phase I study
  Keunchil Park, Eric B. Haura, Natasha B. Leighl, Paul Mitchell, Catherine A. Shu, Nicolas Girard, Santiago Viteri, Ji-Youn Han, Sang-We Kim, Chee Khoon Lee, Joshua K. ...> ;Journal of Clinical Oncology. 2021 Aug 2
• 2 citations
  The Common Thread: A Case of Synchronous Lung Cancers and a Germline CHEK2 Mutation.
  Edward T. Carey, Virginia Ferreira, Elaine Shum, Fang Zhou, Joshua K. Sabari> ;Clinical Lung Cancer. 2021 Jun 12
• 26 citations
  Clinicopathologic Features and Response to Therapy of NRG1 Fusion-Driven Lung Cancers: The eNRGy1 Global Multicenter Registry.
  Alexander Drilon, Michael Duruisseaux, Ji Youn Han, Masaoki Ito, Christina Falcon, Soo-Ryum Yang, Yonina R. Murciano-Goroff, Haiquan Chen, Morihito Okada, Miguel Angel...> ;Journal of Clinical Oncology. 2021 Jun 2
• Durvalumab consolidation therapy in a patient with stage IIIB unresectable NSCLC harboring a MET exon 14 splice site alteration.
  Samuel Cytryn, Virginia Ferreira, Patrick Boland, Abraham Chachoua, Joshua K. Sabari> ;Lung Cancer. 2021 May 29
• 34 citations
  Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes.
  Jason C. Chang, Michael Offin, Christina Falcon, David N Brown, Brian Houck-Loomis, Fanli Meng, Vasilisa A. Rudneva, Helen Won, Sharon Amir, Joseph Montecalvo, Patrice...> ;Clinical Cancer Research. 2021 May 4
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Journal Articles

• PD-L1 Expression, Tumor Mutational Burden, and Response to Immunotherapy in Patients with MET Exon 14 Altered Lung Cancers  
  G J Riely, J Dienstag, C Mrad, J K Sabari, M G Kris, K C Arbour, D F Halpenny, N Rekhtman, R Chen, A J Plodkowski, P K Paik, B T Li, I Bergagnini, M D Offin, C M Rudin..., Annals of Oncology
• Activation of KRAS Mediates Resistance to Targeted Therapy in MET Ex on 14 Mutant Non-Small Cell Lung Cancer  
  Joshua Sabari, MD, Clinical Cancer Research
• Case Report Next-Generation Sequencing Based Detection of Germline and Somatic Alterations in a Patient with Four Metachronous Primary Tumors  
  Joshua K Sabari, Gulisa Turashvili, Vicky Makker, Darragh F Halpenny, ScienceDirect

Lectures

• RET-rearranged lung cancers: Immunophenotype and response to immunotherapy. 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/3/2018