JeffreyDavidChulayMD

Infectious Disease • Gainesville, FL

Physician

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Office
4525 Sw 97th Ter
Gainesville, FL 32608
Phone+1 352-372-3212
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Education & Training

National Capital ConsortiumFellowship, Infectious Disease, 1976 - 1977
The MetroHealth System/Case Western Reserve UniversityResidency, Internal Medicine, 1970 - 1974
Northwestern University The Feinberg School of MedicineClass of 1970

Certifications & Licensure

NC State Medical License 1995 - 2018

Publications & Presentations

PubMed

14 citations
Dose Range Finding Studies with Two RPGR Transgenes in a Canine Model of X-Linked Retinitis Pigmentosa Treated with Subretinal Gene Therapy.
Chunjuan Song, Valerie L. Dufour, Artur V. Cideciyan, Guo-jie Ye, Malgorzata Swider, Judith A Newmark, Adrian M. Timmers, Paulette M. Robinson, David R. Knop, Jeffrey ...> ;Human Gene Therapy. 2020 Jul 15
18 citations
Toxicity and Efficacy Evaluation of an Adeno-Associated Virus Vector Expressing Codon-Optimized RPGR Delivered by Subretinal Injection in a Canine Model of X-linked Re...
Valerie L. Dufour, Artur V. Cideciyan, Guo-jie Ye, Chunjuan Song, Adrian M. Timmers, Perry L. Habecker, Wei Pan, Nicole M. Weinstein, Malgorzata Swider, Amy C. Durham,...> ;Human Gene Therapy. 2020 Feb 14
7 citations
Bridging from Intramuscular to Limb Perfusion Delivery of rAAV: Optimization in a Non-human Primate Study.
Alisha M. Gruntman, Gwladys Gernoux, Qiushi Tang, Guo-jie Ye, Dave R. Knop, Gensheng Wang, Janet M. Benson, Kristen E. Coleman, Allison M. Keeler, Christian Mueller, L...> ;Molecular Therapy. Methods & Clinical Development. 2019 Jun 14
30 citations
Prospective Evaluation of Patients With X-Linked Retinoschisis During 18 Months.
Mark E. Pennesi, David G. Birch, K. Thiran Jayasundera, Maria Parker, Ou Tan, Rabia Gurses-Ozden, Carrie Reichley, Kathleen N Beasley, Paul Yang, Richard G. Weleber, L...> ;Investigative Ophthalmology & Visual Science. 2018 Dec 3
15 citations
Toxicology and Pharmacology of an AAV Vector Expressing Codon-Optimized RPGR in RPGR-Deficient Rd9 Mice
Chunjuan Song, Thomas J. Conlon, Wen-Tao Deng, Kirsten E. Coleman, Ping Zhu, Cayrn Plummer, Savitri Mandapati, Mailin Van Hoosear, Kari B. Green, Peter Sonnentag, Alok...> ;Human Gene Therapy. Clinical Development. 2018 Dec 17
38 citations
Results at 5 Years After Gene Therapy for RPE65-Deficient Retinal Dystrophy.
Mark E. Pennesi, Richard G. Weleber, Paul Yang, Chris Whitebirch, Beverly Thean, Terence R. Flotte, Margaret Humphries, Elvira N. Chegarnov, Kathleen N Beasley, J. Tim...> ;Human Gene Therapy. 2018 Dec 13
18 citations
Safety and Efficacy of AAV5 Vectors Expressing Human or Canine CNGB3 in CNGB3-Mutant Dogs.
Guo Jie Ye, András M. Komáromy, Caroline J. Zeiss, Roberto Calcedo, Christine Harman, Kristin Koehl, Gabriel Stewart, Simone Iwabe, Vince A. Chiodo, William W. Hauswir...> ;Human Gene Therapy. Clinical Development. 2017 Dec 1
41 citations
REPEATABILITY AND LONGITUDINAL ASSESSMENT OF FOVEAL CONE STRUCTURE IN CNGB3-ASSOCIATED ACHROMATOPSIA.
Christopher S Langlo, Laura R Erker, Maria Parker, Emily J. Patterson, Brian P. Higgins, Phyllis Summerfelt, Moataz M Razeen, Frederick T Collison, Gerald A. Fishman, ...> ;Retina. 2017 Oct 1
51 citations
Optimization of Retinal Gene Therapy for X-Linked Retinitis Pigmentosa Due to RPGR Mutations.
William A. Beltran, Artur V. Cideciyan, Shannon E. Boye, Guo-jie Ye, Simone Iwabe, Valerie L. Dufour, Luis Felipe Marinho, Malgorzata Swider, Mychajlo S. Kosyk, Jin Sh...> ;Molecular Therapy. 2017 Aug 2
142 citations
Results at 2 Years after Gene Therapy for RPE65-Deficient Leber Congenital Amaurosis and Severe Early-Childhood-Onset Retinal Dystrophy.
Richard G. Weleber, Mark E. Pennesi, David J. Wilson, Shalesh Kaushal, Laura R Erker, Lauren Jensen, Maureen T. McBride, Terence R. Flotte, Margaret Humphries, Roberto...> ;Ophthalmology. 2016 Jul 1
71 citations
5 Year Expression and Neutrophil Defect Repair after Gene Therapy in Alpha-1 Antitrypsin Deficiency.
Christian Mueller, Gwladys Gernoux, Alisha M. Gruntman, Florie Borel, Emer P. Reeves, Roberto Calcedo, Farshid N. Rouhani, Anthony T. Yachnis, Margaret Humphries, Mart...> ;Molecular Therapy. 2017 Jun 7
22 citations
Safety and Efficacy Evaluation of rAAV2tYF-PR1.7-hCNGA3 Vector Delivered by Subretinal Injection in CNGA3 Mutant Achromatopsia Sheep
Elisha Gootwine, Ron Ofri, Eyal Banin, Alexey Obolensky, Edward Averbukh, Raaya Ezra-Elia, Maya Ross, Hen Honig, Alexander Rosov, Esther Yamin, Guo-jie Ye, David R. Kn...> ;Human Gene Therapy. Clinical Development. 2017 Jun 1
78 citations
Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia.
Christopher S Langlo, Emily J Patterson, Brian P. Higgins, Phyllis Summerfelt, Moataz M Razeen, Laura R Erker, Maria Parker, Frederick T Collison, Gerald A. Fishman, C...> ;Investigative Ophthalmology & Visual Science. 2016 Aug 1
22 citations
Safety and Biodistribution Evaluation in Cynomolgus Macaques of rAAV2tYF-PR1.7-hCNGB3, a Recombinant AAV Vector for Treatment of Achromatopsia.
Guo-jie Ye, Ewa Budzynski, Peter Sonnentag, T Michael Nork, Paul E Miller, Alok K Sharma, James N Ver Hoeve, Leia M Smith, Tara Arndt, Roberto Calcedo, Chantelle Gaski...> ;Human Gene Therapy. Clinical Development. 2016 Mar 1
17 citations
Safety and Biodistribution Evaluation in Cynomolgus Macaques of rAAV2tYF-PR1.7-hCNGB3, a Recombinant AAV Vector for Treatment of Achromatopsia.
Ye, G., Budzynski, E., Sonnentag, P., Nork, T. M., Miller, P. E., Sharma, A. K., Hoeve, J. N., Smith, L., Arndt, T., Calcedo, R., Gaskin, C., Robinson, P., Knop, D. R....> ;Human gene therapy. Clinical development. 2016 Mar 10
10 citations
Safety and Biodistribution Evaluation in CNGB3-deficient Mice of rAAV2tYF-PR1.7-hCNGB3, a Recombinant AAV Vector for Treatment of Achromatopsia.
Ye, G., Budzynski, E., Sonnentag, P., Nork, T. M., Miller, P. E., McPherson, L., Hoeve, J. N., Smith, L., Arndt, T., Mandapati, S., Robinson, P., Calcedo, R., Knop, D....> ;Human gene therapy. Clinical development. 2016 Mar 8
17 citations
Safety and Biodistribution Evaluation in CNGB3-Deficient Mice of rAAV2tYF-PR1.7-hCNGB3, a Recombinant AAV Vector for Treatment of Achromatopsia.
Guo-jie Ye, Ewa Budzynski, Peter Sonnentag, T Michael Nork, Paul E Miller, Leslie McPherson, James N Ver Hoeve, Leia M Smith, Tara Arndt, Savitri Mandapati, Paulette M...> ;Human Gene Therapy. Clinical Development. 2016 Mar 1
14 citations
Recombinant Adeno-Associated Virus Vector Genomes Take the Form of Long-Lived, Transcriptionally Competent Episomes in Human Muscle
Bruce C. Schnepp, Jeffrey D. Chulay, Guo-jie Ye, Terence R. Flotte, Bruce C. Trapnell, Philip R. Johnson> ;Human Gene Therapy. 2016 Jan 1
52 citations
Cone-Specific Promoters for Gene Therapy of Achromatopsia and Other Retinal Diseases.
Guo-jie Ye, Ewa Budzynski, Peter Sonnentag, T Michael Nork, Nader Sheibani, Zafer Gurel, Sanford L. Boye, Jim Peterson, Shannon E. Boye, William W. Hauswirth, Jeffrey ...> ;Human Gene Therapy. 2016 Jan 1
39 citations
Safety and Biodistribution Evaluation in Cynomolgus Macaques of rAAV2tYF-CB-hRS1, a Recombinant Adeno-Associated Virus Vector Expressing Retinoschisin.
Guo-jie Ye, Ewa Budzynski, Peter Sonnentag, Paul E. Miller, Alok K. Sharma, James N. Ver Hoeve, Kellie Howard, David R. Knop, Martha Neuringer, Trevor J. McGill, Jonat...> ;Human Gene Therapy. Clinical Development. 2015 Aug 25
23 citations
Safety and Biodistribution Evaluation of rAAV2tYF-CB-hRS1, a Recombinant Adeno-Associated Virus Vector Expressing Retinoschisin, in RS1-Deficient Mice
Guo-jie Ye, Thomas J. Conlon, Kirsten E. Erger, Peter Sonnentag, Alok K. Sharma, Kellie Howard, David R. Knop, Jeffrey D. Chulay> ;Human Gene Therapy. Clinical Development. 2015 Aug 25
7 citations
Herpes simplex virus clearance during purification of a recombinant adeno-associated virus serotype 1 vector.
Guo-jie Ye, Marina M Scotti, Darby L Thomas, Lijun Wang, David R Knop, Jeffrey D Chulay> ;Human Gene Therapy. Clinical Development. 2014 Dec 1
5 citations
Herpes Simplex Virus Clearance during Purification of a Recombinant Adeno-associated Virus Serotype 1 Vector.
Ye, G., Scotti, M. M., Thomas, D. L., Wang, L., Knop, D. R., Chulay, J. D.> ;Human gene therapy. Clinical development. 2014 Oct 2
110 citations
Human Treg responses allow sustained recombinant adeno-associated virus- mediated transgene expression
Christian Mueller, Jeffrey D. Chulay, Bruce C. Trapnell, Margaret Humphries, Brenna Carey, Robert A. Sandhaus, Noel G. McElvaney, Louis M. Messina, Qiushi Tang, Farshi...> ;The Journal of Clinical Investigation. 2013 Dec 2
4 citations
Development, validation and use of ELISA for antibodies to human alpha-1 antitrypsin.
Guo-jie Ye, Regina Oshins, Farshid N. Rouhani, Mark L. Brantly, Jeffrey D. Chulay> ;Journal of Immunological Methods. 2013 Feb 28
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Press Mentions

AGTC Appoints Matthew Feinsod, M.D. As Interim Chief Medical OfficerSeptember 5th, 2017

Grant Support

Phase 2 Study Of Raav1-Cb-Haat For Treatment Of Alpha-1 Antitrypsin DeficiencyFood And Drug Administration2010–2011
Phase 1/2 Trial Of Raav2-Cb-Hrpe65 (Bb-Ind 13848, 11 SEP 2009) For Leber CongenitFood And Drug Administration2010–2011
Raav5-Hcngb3 Gene Therapy For Achromatopsia: Efficacy In A Dog ModelNational Eye Institute2010
Alphavirus Replicon Vaccines Against Botulinum Neurotox*National Institute Of Allergy And Infectious Diseases2003–2006
HIV Subtype C Alphavirus Vaccine Design &DevelopmentNational Institute Of Allergy And Infectious Diseases2002–2003

JeffreyDavidChulayMD

Dr. Chulay is on Doximity

Education & Training

Certifications & Licensure

Publications & Presentations

Press Mentions

Grant Support

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