JosephMinhowChanMD

PubMed

• Functional Characterisation of the ATOH1 Molecular Subtype Indicates a Pro-Metastatic Role in Small Cell Lung Cancer.
  Catozzi, A., Peiris-Pagès, M., Humphrey, S., Revill, M., Morgan, D., Roebuck, J., Chen, Y., Davies-Williams, B., Lallo, A., Galvin, M., Pearce, S., Kerr, A., Priest, L...> ;Biorxiv. 2024 Feb 17
• Immune heterogeneity in small-cell lung cancer and vulnerability to immune checkpoint blockade.
  Barzin Y Nabet, Habib Hamidi, Myung Chang Lee, Romain Banchereau, Stefanie Morris, Leah Adler, Velimir Gayevskiy, Ahmed M Elhossiny, Minu K Srivastava, Namrata S Patil...> ;Cancer Cell. 2024 Mar 11
• Role of CD38 in anti-tumor immunity of small cell lung cancer.
  Hirokazu Taniguchi, Shweta S Chavan, Hiroshi Mukae, Triparna Sen, Andrew Chow, Joseph M Chan, Charles M Rudin> ;Frontiers in Immunology. 2024 Jan 1
• 1 citations
  CRACD loss promotes small cell lung cancer tumorigenesis via EZH2-mediated immune evasion.
  Shengzhe Zhang, Kee-Beom Kim, Yuanjian Huang, Dong-Wook Kim, Bongjun Kim, Kyung-Pil Ko, Gengyi Zou, Jie Zhang, Sohee Jun, Nicole A Kirk, Ye Eun Hwang, Young Ho Ban, Ch...> ;Biorxiv. 2023 May 17
• 16 citations
  Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade.
  Pai, J., Hellmann, M., Sauter, J., Mattar, M., Rizvi, H., Woo, H., Shah, N., Nguyen, E., Uddin, F., Quintanal-Villalonga, A., Chan, J., Manoj, P., Allaj, V., Baine, M....> ;Cancer Cell. 2023 Apr 10
• 1 citations
  ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer.
  Dan Li, Yu Zhan, Naitao Wang, Fanying Tang, Cindy J Lee, Gabriella Bayshtok, Amanda R Moore, Elissa W P Wong, Mohini R Pachai, Yuanyuan Xie, Jessica Sher, Jimmy L Zhao...> ;Science Advances. 2023 Apr 5
• 18 citations
  The ectonucleotidase CD39 identifies tumor-reactive CD8T cells predictive of immune checkpoint blockade efficacy in human lung cancer.
  Chow, A., Uddin, F., Liu, M., Dobrin, A., Nabet, B., Mangarin, L., Lavin, Y., Rizvi, H., Tischfield, S., Quintanal-Villalonga, A., Chan, J., Shah, N., Allaj, V., Manoj...> ;Immunity. 2023 Jan 10
• Protocol to dissociate, process, and analyze the human lung tissue using single-cell RNA-seq.
  Álvaro Quintanal-Villalonga, Joseph M Chan, Ignas Masilionis, Vianne Ran Gao, Yubin Xie, Viola Allaj, Andrew Chow, John T Poirier, Dana Pe'er, Charles M Rudin, Linas M...> ;STAR Protocols. 2022 Dec 16
• 74 citations
  Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling.
  Joseph M Chan, Samir Zaidi, Jillian R Love, Jimmy L Zhao, Manu Setty, Kristine M Wadosky, Anuradha Gopalan, Zi-Ning Choo, Sitara Persad, Jungmin Choi, Justin LaClair, ...> ;Science. 2022 Sep 9
• 23 citations
  Targeting Lysine-Specific Demethylase 1 Rescues Major Histocompatibility Complex Class I Antigen Presentation and Overcomes Programmed Death-Ligand 1 Blockade Resistan...
  Evelyn M Nguyen, Hirokazu Taniguchi, Joseph M Chan, Yingqian A Zhan, Xiaoping Chen, Juan Qiu, Elisa de Stanchina, Viola Allaj, Nisargbhai S Shah, Fathema Uddin, Parvat...> ;Journal of Thoracic Oncology. 2022 Aug 1
• 36 citations
  WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC.
  Hirokazu Taniguchi, Rebecca Caeser, Shweta S Chavan, Yingqian A Zhan, Andrew Chow, Parvathy Manoj, Fathema Uddin, Hidenori Kitai, Rui Qu, Omar Hayatt, Nisargbhai S Sha...> ;Cell Reports. 2022 May 17
• 13 citations
  Inhibition of XPO1 sensitizes small cell lung cancer to first- and second-line chemotherapy.
  Álvaro Quintanal-Villalonga, Hirokazu Taniguchi, Yuan Hao, Andrew Chow, Yingqian Zhan, Shweta S Chavan, Fathema Uddin, Viola Allaj, P. Manoj, Nisargbhai S. Shah, Josep...> ;Cancer Research. 2021 Nov 23
• 118 citations
  Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer
  Joseph M. Chan, Álvaro Quintanal-Villalonga, Vianne R. Gao, Yubin Xie, Viola Allaj, Ojasvi Chaudhary, Ignas Masilionis, Jacklynn V. Egger, Andrew Chow, Thomas Walle, M...> ;Cancer Cell. 2021 Nov 8
• 22 citations
  Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation.
  Álvaro Quintanal-Villalonga, Hirokazu Taniguchi, Yingqian Zhan, Maysun Hasan, Shweta S. Chavan, Fanli Meng, Fathema Uddin, Viola Allaj, P. Manoj, Nisargbhai S. Shah, J...> ;Journal of Hematology & Oncology. 2021 Oct 16
• 85 citations
  Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity.
  , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Cancer Cell. 2021 Jul 12
• 50 citations
  Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformation.
  Álvaro Quintanal-Villalonga, Hirokazu Taniguchi, Yingqian Zhan, Maysun Hasan, Shweta S Chavan, Fanli Meng, Fathema Uddin, P. Manoj, Mark T.A. Donoghue, Helen Won, Jose...> ;Cancer Discovery. 2021 Jun 21
• 2 citations
  Publisher Correction: Lineage plasticity in cancer: a shared pathway of therapeutic resistance.
  Álvaro Quintanal-Villalonga, Helena A. Yu, Dana Pe'er, Sawyers Charles L, Triparna Sen, Charles M. Rudin> ;Nature Reviews. Clinical Oncology. 2020 Jun 1
• 179 citations
  Tumor Analyses Reveal Squamous Transformation and Off-Target Alterations As Early Resistance Mechanisms to First-line Osimertinib in EGFR-Mutant Lung Cancer
  Adam J. Schoenfeld, Joseph M. Chan, Daisuke Kubota, Hiroki Sato, Hira Rizvi, Yahya Daneshbod, Jason C. Chang, Paul K. Paik, Michael Offin, Maria E. Arcila, Monika A. D...> ;Clinical Cancer Research. 2020 Jun 1
• 220 citations
  Lineage plasticity in cancer: a shared pathway of therapeutic resistance.
  Álvaro Quintanal-Villalonga, Joseph M. Chan, Helena A. Yu, Dana Pe'er, Sawyers Charles L, Triparna Sen, Charles M. Rudin> ;Nature Reviews. Clinical Oncology. 2020 Mar 9
• 194 citations
  Concurrent RB1 and TP53 Alterations Define a Subset of EGFR-Mutant Lung Cancers at risk for Histologic Transformation and Inferior Clinical Outcomes
  Michael Offin, Joseph M. Chan, Megan Tenet, Hira Rizvi, Ronglai Shen, Gregory J. Riely, Natasha Rekhtman, Yahya Daneshbod, Álvaro Quintanal-Villalonga, Alexander V Pen...> ;Journal of Thoracic Oncology. 2019 Oct 1
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