OmarAbdel-WahabMD

PubMed

• Mixed histiocytic neoplasms: A multicentre series revealing diverse somatic mutations and responses to targeted therapy.
  Joshua S Friedman, Benjamin H Durham, Anne S Reiner, Mariko Yabe, Kseniya Petrova-Drus, Ahmet Dogan, Melissa Pulitzer, Klaus J Busam, Jasmine H Francis, Raajit K Rampa...> ;British Journal of Haematology. 2024 Apr 12
• New means and challenges in the targeting of BTK.
  Vindhya Nawaratne, Anya K Sondhi, Omar Abdel-Wahab, Justin Taylor> ;Clinical Cancer Research. 2024 Apr 5
• A new SAGA for AML: targeting SGF29 in AML.
  Jeetayu Biswas, Omar Abdel-Wahab> ;Blood. 2024 Feb 22
• SWI/SNF regulation of germinal center fate and lymphomagenesis.
  Quinlan Sievers, Omar Abdel-Wahab> ;Cancer Cell. 2024 Apr 8
• Targeting the cBAF complex in T-ALL.
  Bingyi Chen, Omar Abdel-Wahab> ;Blood. 2024 Feb 15
• 5 citations
  Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
  Skye Montoya, Jessie Bourcier, Mark Noviski, Hao Lu, Meghan C Thompson, Alexandra Chirino, Jacob Jahn, Anya K Sondhi, Stefan Gajewski, Ying Siow May Tan, Stephanie Yun...> ;Science. 2024 Feb 2
• A microglia clonal inflammatory disorder in Alzheimer's Disease.
  Rocio Vicario, Stamatina Fragkogianni, Leslie Weber, Tomi Lazarov, Yang Hu, Samantha Y Hayashi, Barbara P Craddock, Nicholas D Socci, Araitz Alberdi, Ann Baako, Oyku A...> ;Biorxiv. 2024 Jan 25
• Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML.
  Emily C Wheeler, Benjamin J E Martin, William C Doyle, Sofia Neaher, Caroline A Conway, Caroline N Pitton, Rebecca A Gorelov, Melanie Donahue, Johann C Jann, Omar Abde...> ;Science Translational Medicine. 2024 Jan 3
• Targeting lysine demethylase 6B ameliorates ASXL1 truncation-mediated myeloid malignancies in preclinical models.
  Ge, G., Zhang, P., Sui, P., Chen, S., Yang, H., Guo, Y., Rubalcava, I., Noor, A., Delma, C., Agosto-Peña, J., Geng, H., Medina, E., Liang, Y., Nimer, S., Mesa, R., Abd...> ;The Journal of Clinical Investigation. 2024 Jan 2
• 1 citations
  BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state.
  Xiao, M., Kondo, S., Nomura, M., Kato, S., Nishimura, K., Zang, W., Zhang, Y., Akashi, T., Viny, A., Shigehiro, T., Ikawa, T., Yamazaki, H., Fukumoto, M., Tanaka, A., ...> ;Nature Communications. 2023 Dec 15
• 1 citations
  SRSF2 plays an unexpected role as reader of mC on mRNA, linking epitranscriptomics to cancer.
  Ma, H., Bizet, M., Soares Da Costa, C., Murisier, F., de Bony, E., Wang, M., Yoshimi, A., Lin, K., Riching, K., Wang, X., Beckman, J., Arya, S., Droin, N., Calonne, E....> ;Molecular Cell. 2023 Dec 7
• SRSF2 mutation cooperates with ASXL1 truncated alteration to accelerate leukemogenesis.
  Pinpin Sui, Guo Ge, Shi Chen, Jiaojiao Bai, Ivan P Rubalcava, Hui Yang, Ying Guo, Peng Zhang, Ying Li, Edward A Medina, Mingjiang Xu, Omar Abdel-Wahab, Robert Bradley,...> ;Leukemia. 2024 Feb 1
• 4 citations
  Classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): A state-of-the-art report on behalf of the International Cons...
  Maximilian Stahl, Jan Philipp Bewersdorf, Zhuoer Xie, Matteo Giovanni Della Porta, Rami Komrokji, Mina L Xu, Omar Abdel-Wahab, Justin Taylor, David P Steensma, Daniel ...> ;Blood Reviews. 2023 Nov 1
• 4 citations
  Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia.
  Claudia Bruedigam, Amy H Porter, Axia Song, Gerjanne Vroeg In de Wei, Thomas Stoll, Jasmin Straube, Leanne Cooper, Guidan Cheng, Vivian F S Kahl, Alexander P Sobinoff,...> ;Nature Cancer. 2024 Jan 1
• Enhanced clinical assessment of hematologic malignancies through routine paired tumor and normal sequencing.
  Ryan N Ptashkin, Mark D Ewalt, Gowtham Jayakumaran, Iwona Kiecka, Anita S Bowman, JinJuan Yao, Jacklyn Casanova, Yun-Te David Lin, Kseniya Petrova-Drus, Abhinita S Moh...> ;Nature Communications. 2023 Oct 28
• Histiocytic neoplasm subtypes differ in their MAP2K1 mutational type.
  Jean-François Emile, Zofia Hélias-Rodzewicz, Benjamin H Durham, Sébastien Héritier, Malik da Silva, Komel Younas, Fleur Cohen-Aubart, Omar Abdel-Wahab, Eli L Diamond, ...> ;Blood Advances. 2023 Dec 12
• Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia.
  Katherine Knorr, Jahan Rahman, Caroline Erickson, Eric Wang, Mara Monetti, Zhuoning Li, Juliana Ortiz-Pacheco, Andrew Jones, Sydney X Lu, Robert F Stanley, Maria Baez,...> ;Nature Cancer. 2023 Dec 1
• Mutant PIK3CA is a targetable driver alteration in histiocytic neoplasms.
  Benjamin H Durham, Oshrat Hershkovitz-Rokah, Omar Abdel-Wahab, Mariko Yabe, Young Rock Chung, Gilad Itchaki, Maayan Ben-Sasson, Vered A Asher-Guz, David Groshar, Seyra...> ;Blood Advances. 2023 Dec 12
• Genetic Basis of Relapse after GPRC5D-Targeted CAR T Cells.
  Xiaoli Mi, Alex Penson, Omar Abdel-Wahab, Sham Mailankody> ;The New England Journal of Medicine. 2023 Oct 12
• E7820, an anti-cancer sulfonamide, degrades RBM39 in patients with splicing factor mutant myeloid malignancies: a phase II clinical trial.
  Jan Philipp Bewersdorf, Justin Taylor, Xiaoli Mi, Namrata Sonia Chandhok, Justin Watts, Andriy Derkach, Mateusz Wysocki, Sydney X Lu, Jessie Bourcier, Simon J Hogg, Ja...> ;Leukemia. 2023 Dec 1
• 1 citations
  Vemurafenib and Obinutuzumab as Frontline Therapy for Hairy Cell Leukemia.
  Devlin, S., von Keudell, G., Vemuri, S., Shukla, M., Falco, V., Cuello, B., Park, J., Durham, B., Winer, E., Huntington, S., Gore, S., Stone, R., Abdel-Wahab, O., Tall...> ;NEJM Evidence. 2023 Oct 1
• Genome-Wide Association Study Identifies the First Germline Genetic Variant Associated With Erdheim-Chester Disease.
  Javier Martínez-López, Ana Márquez, Francesco Pegoraro, Lourdes Ortiz-Fernández, Marialbert Acosta-Herrera, Martin Kerick, Elena Gelain, Eli L Diamond, Benjamin H Durh...> ;Arthritis & Rheumatology. 2024 Jan 1
• 7 citations
  Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths.
  Mariela Cortés-López, Paulina Chamely, Allegra G Hawkins, Robert F Stanley, Ariel D Swett, Saravanan Ganesan, Tarek H Mouhieddine, Xiaoguang Dai, Lloyd Kluegel, Celine...> ;Cell Stem Cell. 2023 Sep 7
• Overlaid Transcriptional and Proteome Analyses Identify Mitotic Kinesins as Important Targets of Arylsulfonamide-Mediated RBM39 Degradation.
  Seemon Coomar, Pedro Mota, Alexander Penson, Jürg Schwaller, Omar Abdel-Wahab, Dennis Gillingham> ;Molecular Cancer Research. 2023 Aug 1
• 1 citations
  The bone marrow stroma in human myelodysplastic syndrome reveals alterations that regulate disease progression.
  Youmna S Kfoury, Fei Ji, Esha Jain, Michael Mazzola, Giulia Schiroli, Ani Papazian, Francois Mercier, David B Sykes, Anna Kiem, Mark Randolph, Laura M Calvi, Omar Abde...> ;Blood Advances. 2023 Nov 14
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Abstracts/Posters

• Spliceosomal Disruption of the Non-Canonical SWI/SNF Chromatin Remodeling Complex in SF3B1 Mutant Leukemias
  Omar Abdel-Wahab, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• First Line Chemo-Free Therapy with the BRAF Inhibitor Vemurafenib Combined with Obinutuzumab Is Effective in Patients with Hcl
  Omar Abdel-Wahab, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Aberrant RNA Splicing Contributes to the Pathogenesis of EVI-Rearranged Myeloid Leukemias
  Omar Abdel-Wahab, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Lectures

• Selinexor, a First-in-Class XPO1 Inhibitor, Is Efficacious and Tolerable in Patients with Myelodysplastic Syndromes Refractory to Hypomethylating Agents 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Activating Mutations in CSF1R and Additional Receptor Tyrosine Kinases in Sporadic and Familial Histiocytic Neoplasms 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Multimodal Single-Cell Profiling Defines the Epigenetic Determinants of Chronic Lymphocytic Leukemia Evolution 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• RUNX1 Deficiency Cooperates with SRSF2 Mutation to Further Disrupt RNA Splicing and Exacerbate Myelodysplastic Syndromes in Mouse Models 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Hematologic Malignancies Arising in Patients with Germ Cell Tumors: Secondary Somatic Differentiation of Hematopoietic Malignancies from Germ Cell Precursors 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
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