PatrickJBrennanMD

PubMed

• TCF1-LEF1 co-expression identifies a multipotent progenitor cell (T2-MPP) across human allergic diseases.
  Radomir Kratchmarov, Sarah Djeddi, Garrett Dunlap, Wenqin He, Xiaojiong Jia, Caitlin M Burk, Tessa Ryan, Alanna McGill, Jessica R Allegretti, Raghu P Kataru, Babak J M...> ;Nature Immunology. 2024 Apr 8
• Pla2g5 contributes to viral-like-induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment.
  Masaya Koganesawa, Daniel F Dwyer, Kinan Alhallak, Jun Nagai, Kendall Zaleski, Sachin Samuchiwal, Hayashi Hiroaki, Airi Nishida, Thomas I Hirsch, Patrick J Brennan, Ma...> ;Immunology. 2024 May 1
• PPARγ agonist treatment reduces fibroadipose tissue in secondary lymphedema by exhausting fibroadipogenic PDGFRα+ mesenchymal cells.
  Chen, Z., Ghavimi, S., Wu, M., McNamara, J., Barreiro, O., Maridas, D., Kratchmarov, R., Siegel, A., Djeddi, S., Gutierrez-Arcelus, M., Brennan, P., Padera, T., von An...> ;JCI Insight. 2023 Dec 22
• 3 citations
  Early-life fecal metabolomics of food allergy.
  Kathleen A Lee-Sarwar, Yih-Chieh Chen, Jessica Lasky-Su, Rachel S Kelly, Robert S Zeiger, George T O'Connor, Leonard B Bacharier, Xiaojiong Jia, Avraham Beigelman, Dia...> ;Allergy. 2023 Feb 1
• 2 citations
  Patient Characteristics Associated With Reactions to Mrgprx2-Activating Drugs in an Electronic Health Record-Linked Biobank.
  Dinah Foer, Matthew Wien, Elizabeth W Karlson, Wenyu Song, Joshua A Boyce, Patrick J Brennan> ;The Journal of Allergy and Clinical Immunology. in Practice. 2023 Feb 1
• 85 citations
  Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs.
  Ana Dioun Broyles, Aleena Banerji, Sara Barmettler, Catherine M. Biggs, Kimberly G. Blumenthal, Patrick J. Brennan, Rebecca G. Breslow, Knut Brockow, Kathleen M. Buchh...> ;The Journal of Allergy and Clinical Immunology. in Practice. 2020 Oct 1
• 18 citations
  A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling
  Carlos Donado, Anh Cao, Daimon P. Simmons, Ben A. Croker, Patrick J. Brennan, Michael B. Brenner> ;Cell Reports. 2020 Apr 7
• 24 citations
  Glycolipid-Mediated Basophil Activation in Alpha-Gal Allergy
  Onyinye I. Iweala, Shailesh K. Choudhary, Claire T. Addison, Cole J. Batty, Camille M. Kapita, Claire Amelio, Alexander J. Schuyler, Shenglou Deng, Eric M. Bachelder, ...> ;The Journal of Allergy and Clinical Immunology. 2020 Feb 20
• 17 citations
  Discovery of Salmonella trehalose phospholipids reveals functional convergence with mycobacteria.
  Peter Reinink, Jeffrey Buter, Vivek K. Mishra, Eri Ishikawa, Tan-Yun Cheng, Peter Willemsen, Steffen Porwollik, Patrick J. Brennan, Eva Heinz, Jacob A. Mayfield, Gordo...> ;The Journal of Experimental Medicine. 2019 Apr 1
• 98 citations
  Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions.
  Maria Gutierrez-Arcelus, Nikola Teslovich, Alex R. Mola, Rafael B. Polidoro, Aparna Nathan, Hyun Wha Kim, Susan K. Hannes, Kamil Slowikowski, Gerald F. Watts, Ilya Kor...> ;Nature Communications. 2019 Feb 8
• 33 citations
  Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy.
  Kathleen Lee-Sarwar, Rachel S. Kelly, Jessica Lasky-Su, D. Branch Moody, Alex R. Mola, Tan-Yun Cheng, Laurie E. Comstock, Robert S. Zeiger, George T. O'Connor, Megan S...> ;The Journal of Allergy and Clinical Immunology. 2018 May 2
• 30 citations
  Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface.
  Patrick J. Brennan, Tan-Yun Cheng, Daniel G. Pellicci, Gerald F. Watts, Natacha Veerapen, David C. Young, Jamie Rossjohn, Gurdyal S. Besra, Dale I. Godfrey, Michael B....> ;Proceedings of the National Academy of Sciences of the United States of America. 2017 Aug 1
• 26 citations
  Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets
  Eleanor Clancy-Thompson, Gui Zhen Chen, Paul M Tyler, Mariah M. Servos, Marta Barisa, Patrick J. Brennan, Hidde L. Ploegh, Stephanie K. Dougan> ;Journal of Immunology. 2017 Jul 1
• 43 citations
  Activation strategies for invariant natural killer T cells.
  Ayano C. Kohlgruber, Carlos Donado, Nelson M. LaMarche, Michael B. Brenner, Patrick J. Brennan> ;Immunogenetics. 2016 Jul 25
• 149 citations
  Safety, Costs, and Efficacy of Rapid Drug Desensitizations to Chemotherapy and Monoclonal Antibodies
  David E. Sloane, Usha Govindarajulu, Jacob Harrow-Mortelliti, William H. Barry, Florence Ida Hsu, David I. Hong, Tanya M. Laidlaw, Ross I. Palis, Henry J. Legere, Supi...> ;The Journal of Allergy and Clinical Immunology. in Practice. 2016 May 1
• 48 citations
  The transcriptional programs of iNKT cells.
  Edy Y. Kim, Lydia Lynch, Patrick J. Brennan, Nadia R. Cohen, Michael B. Brenner> ;Seminars in Immunology. 2015 Feb 1
• 255 citations
  Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue
  Lydia Lynch, Xavier Michelet, Sai Zhang, Patrick J. Brennan, Ashley Moseman, Chantel Lester, Gurdyal S. Besra, Emilie E. Vomhof-DeKrey, Mike Tighe, Hui-Fern Koay, Dale...> ;Nature Immunology. 2015 Jan 1
• 79 citations
  Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction.
  Patrick J. Brennan, Raju V. V. Tatituri, Christian Heiss, Gerald F. Watts, Fong-Fu Hsu, Natacha Veerapen, Liam R. Cox, Parastoo Azadi, Gurdyal S. Besra, Michael B. Bre...> ;Proceedings of the National Academy of Sciences of the United States of America. 2014 Sep 16
• 35 citations
  Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells.
  Xinli Hu, Hyun Wha Kim, Towfique Raj, Patrick J. Brennan, Gosia Trynka, Nikola Teslovich, Kamil Slowikowski, Wei-Min Chen, Suna Onengut, Clare Baecher-Allan, Philip L....> ;Plos Genetics. 2014 Jun 26
• Application of User-Guided Automated Cytometric Data Analysis to Large-Scale Immunoprofiling of Invariant Natural Killer T Cells
  Patrick J Brennan, Michael B Brenner, Soumya Raychaudhuri> ;Proceedings of the National Academy of Sciences. 2013 Nov 06
• Identification of transcriptional regulators in the mouse immune system.
  Jojic V, Shay T, Sylvia K, Zuk O, Sun X, Kang J, Regev A, Koller D, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim...> ;Nat. Immunol.. 2013-06-01
• The transcriptional landscape of αβ T cell differentiation.
  Mingueneau, M.,Kreslavsky, T.,Gray, D.,Heng, T.,Cruse, R.,Ericson, J.,Bendall, S.,Spitzer, M. H.,Nolan, G. P.,Kobayashi, K.,von Boehmer, H.,Mathis, D.,Benoist, C.,Best...> ;Nat. Immunol.. 2013 Jun
• 590 citations
  Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions
  Patrick J. Brennan, Manfred Brigl, Michael B. Brenner> ;Nature Reviews. Immunology. 2013 Feb 1
• Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.
  Cohen NR, Brennan PJ, Shay T, Watts GF, Brigl M, Kang J, Brenner MB> ;Nat. Immunol.. 2013-01-01
• 241 citations
  Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals
  Patrick J. Brennan, Raju V. V. Tatituri, Manfred Brigl, Aamit Tuli, Joseph P. Sanderson, Stephan D. Gadola, Fong-Fu Hsu, Gurdyal S. Besra, Michael B. Brenner, Kim, E. ...> ;Nature Immunology. 2011 Dec 1
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