PeterMFischerMD

PubMed

• 3 citations
  GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors
  Abigail L. Emtage, Shailesh N. Mistry, Peter Fischer, Barrie Kellam, Charles A. Laughton> ;Journal of Biomolecular Structure & Dynamics. 2017 Sep 1
• 61 citations
  Approved and Experimental Small-Molecule Oncology Kinase Inhibitor Drugs: A Mid-2016 Overview.
  Peter Fischer> ;Medicinal Research Reviews. 2017 Mar 1
• 7 citations
  Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1
  Gopal P. Jadhav, Ishwinder Kaur, Maryati Maryati, Blessing Airhihen, Peter Fischer, G. Sebastiaan Winkler> ;Bioorganic & Medicinal Chemistry Letters. 2015 Oct 1
• 46 citations
  Coagulation factor XII protease domain crystal structure.
  Monika Pathak, P. Wilmann, J. Awford, Chan Li, Badraldin Kareem Hamad, Peter Fischer, Ingrid Dreveny, Lodewijk V. Dekker, Jonas Emsley> ;Journal of Thrombosis and Haemostasis. 2015 Apr 1
• Active colloidal microdrills.
  Gibbs JG, Fischer P> ;Chem. Commun. (Camb.). 2015-03-11
• 15 citations
  A facile approach to tryptophan derivatives for the total synthesis of argyrin analogues.
  Chou-Hsiung Chen, Sivaneswary Genapathy, Peter Fischer, Weng C. Chan> ;Organic & Biomolecular Chemistry. 2014 Nov 19
• 29 citations
  Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction.
  Tummala Rama Krishna Reddy, Chan Li, Xiaoxia Guo, Peter Fischer, Lodewijk V. Dekker> ;Bioorganic & Medicinal Chemistry. 2014 Oct 1
• 43 citations
  Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73
  Frankie Lam, Abdullahi Y. Abbas, Hao Shao, Theodosia Teo, Julian Adams, Peng Li, Tracey D. Bradshaw, Peter Fischer, Elisabeth Jane Walsby, Chris Pepper, Yi Chen, Jian ...> ;Oncotarget. 2014 Aug 2
• 9 citations
  Investigation of the flexibility of protein kinases implicated in the pathology of Alzheimer's disease.
  Michael P. Mazanetz, Charles A. Laughton, Peter Fischer> ;Molecules. 2014 Jun 30
• 21 citations
  A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity
  Maryati Maryati, Ishwinder Kaur, Gopal P. Jadhav, Loyin Olotu-Umoren, Blessing Oveh, Lubna Hashmi, Peter Fischer, G. Sebastiaan Winkler> ;Nucleic Acids Research. 2014 Mar 1
• 56 citations
  A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine
  Elisabeth Jane Walsby, Guy Pratt, Hao Shao, Abdullah Y. Abbas, Peter Fischer, Tracey D. Bradshaw, Paul Brennan, Christopher Fegan, Shudong Wang, Chris Pepper> ;Oncotarget. 2014 Jan 30
• 28 citations
  Synthesis, structure-activity relationship and biological evaluation of 2,4,5-trisubstituted pyrimidine CDK inhibitors as potential anti-tumour agents.
  Hao Shao, Shenhua Shi, David W. Foley, Frankie Lam, Abdullah Y. Abbas, Xiangrui Liu, Shiliang Huang, Xiangrui Jiang, Nadiah Baharin, Peter Fischer, Shudong Wang> ;European Journal of Medicinal Chemistry. 2013 Dec 1
• 10 citations
  5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2
  Michael P. Dickens, Patricia Roxburgh, Andreas K. Hock, Mokdad Mezna, Barrie Kellam, Karen H. Vousden, Peter Fischer> ;Bioorganic & Medicinal Chemistry. 2013 Nov 15
• 11 citations
  Synthesis and in vitro and in vivo characterization of highly β1-Selective β-Adrenoceptor partial agonists
  Shailesh N. Mistry, Jillian G. Baker, Peter Fischer, Stephen J. Hill, Sheila M. Gardiner, Barrie Kellam> ;Journal of Medicinal Chemistry. 2013 May 23
• High cortisol and low folate are the only routine blood tests predicting probable Alzheimer's disease after age 75-results of the Vienna Transdanube Aging Study.
  Hinterberger M, Zehetmayer S, Jungwirth S, Huber K, Krugluger W, Leitha T, Krampla W, Tragl K, Fischer P> ;J Am Geriatr Soc. 2013-04-01
• 79 citations
  Substituted 4-(thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: synthesis, X-ray crystal structures, structure-activity relationship, and an...
  Hao Shao, Shenhua Shi, Shiliang Huang, Alison J. Hole, Abdullahi Y. Abbas, Sonja Baumli, Xiangrui Liu, Frankie Lam, David W. Foley, Peter Fischer, Martin E.M. Noble, J...> ;Journal of Medicinal Chemistry. 2013 Feb 14
• 39 citations
  Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
  Alison J. Hole, Sonja Baumli, Hao Shao, Shenhua Shi, Shiliang Huang, Chris Pepper, Peter Fischer, Shudong Wang, Jane A. Endicott, Martin E.M. Noble> ;Journal of Medicinal Chemistry. 2013 Feb 14
• One target-two different binding modes: structural insights into gevokizumab and canakinumab interactions to interleukin-1β.
  Blech M, Peter D, Fischer P, Bauer MMT, Hafner M, Zeeb M, Nar H> ;J. Mol. Biol.. 2013-01-09
• 69 citations
  Synthetic lethal targeting of DNA double‐strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors
  Rebeka Sultana, Daniel R. McNeill, Rachel Abbotts, Mohammed Z. Mohammed, Małgorzata Z. Zdzienicka, Haitham Qutob, Claire Seedhouse, Charles A. Laughton, Peter Fischer,...> ;International Journal of Cancer. 2012 Nov 15
• 25 citations
  Three-dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction.
  Tummala Rama Krishna Reddy, Chan Li, Peter Fischer, Lodewijk V. Dekker> ;Chemmedchem. 2012 May 29
• 7 citations
  In vitro antitumor mechanism of a novel cyclin-dependent kinase inhibitor CDKI-83
  Xiangrui Liu, Frankie Lam, Shenhua Shi, Peter Fischer, Shudong Wang> ;Investigational New Drugs. 2012 Jun 1
• 28 citations
  Small molecules that bind the Mdm2 RING stabilize and activate p53
  Patricia Roxburgh, Andreas K. Hock, Michael P. Dickens, Mokdad Mezna, Peter Fischer, Karen H. Vousden> ;Carcinogenesis. 2012 Apr 1
• 49 citations
  CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol.
  Xiangrui Liu, Shenhua Shi, Frankie Lam, Chris Pepper, Peter Fischer, Shudong Wang> ;International Journal of Cancer. 2012 Mar 1
• The role of memory-related gene polymorphisms, KIBRA and CLSTN2, on replicate memory assessment in the elderly.
  Sédille-Mostafaie N, Sebesta C, Huber KR, Zehetmayer S, Jungwirth S, Tragl KH, Fischer P, Krugluger W> ;J Neural Transm. 2012-01-01
• 21 citations
  Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.
  Stuart Wilson, Butrus Atrash, Clare Barlow, Sue Eccles, Peter Fischer, Angela Hayes, Lloyd R. Kelland, Wayne Jackson, Michael Jarman, Amin Mirza, Javier Moreno, Bernar...> ;Bioorganic & Medicinal Chemistry. 2011 Nov 15
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