RaviVChariMD

PubMed

• Evaluation of Targets for Maytansinoid ADC Therapy Using a Novel Radiochemical Assay.
  Lai, K. C.,Deckert, J.,Setiady, Y. Y.,Shah, P.,Wang, L.,Chari, R.,Lambert, J. M.> ;Pharm. Res.. 2015 Jan 30
• 268 citations
  Antibody conjugate therapeutics: challenges and potential.
  Beverly A. Teicher, Ravi V.J. Chari> ;Clinical Cancer Research. 2011 Oct 15
• 28 citations
  World Antibody Drug Conjugate Summit Europe: February 21-23, 2011; Frankfurt, Germany.
  Alain Beck, Peter D. Senter, Ravi J. Chari> ;Mabs. 2011 Jul 1
• 106 citations
  Long- and short-range electrostatic interactions affect the rheology of highly concentrated antibody solutions.
  Ravi Chari, Kavita S. Jerath, Advait Badkar, Devendra S. Kalonia> ;Pharmaceutical Research. 2009 Oct 1
• 10 citations
  Development of Improved Empirical Models for Estimating the Binding Constant of a β-Cyclodextrin Inclusion Complex
  Ravi Chari, Farooq Qureshi, John Moschera, Ralph Tarantino, Devendra S. Kalonia> ;Pharmaceutical Research. 2009 Jan 1
• 20 citations
  The role of halogen substitution in classical cannabinoids: a CB1 pharmacophore model.
  Spyros P. Nikas, Jolanta Grzybowska, Demetris P. Papahatjis, Avgui Charalambous, Ali R. Banijamali, Ravi Chari, Pusheng Fan, Therapia Kourouli, Sonyuan Lin, Albert J. ...> ;The AAPS Journal. 2004 Dec 1
• Magnetically aligned bicelles to study the orientation of lipophilic ligands in membrane bilayers.
  Guo, J., Yang, D. P., Chari, R., Tian, X., Pavlopoulos, S., Lu, D., Makriyannis, A.> ;J Med Chem. 2008 Nov 13
• Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'.
  Papahatjis, D. P., Nikas, S. P., Kourouli, T., Chari, R., Xu, W., Pertwee, R. G., Makriyannis, A.> ;J Med Chem. 2003 Jul 17
• The development of antibody delivery systems to target cancer with highly potent maytansinoids.
  Liu, C., Chari, R. V.> ;Expert Opin Investig Drugs. 1997 Feb
• Design of antibody-maytansinoid conjugates allows for efficient detoxification via liver metabolism.
  Sun, X., Widdison, W., Mayo, M., Wilhelm, S., Leece, B., Chari, R., Singh, R., Erickson, H.> ;Bioconjug Chem. 2011 Apr 20
• The antileukemic efficacy of an immunotoxin composed of a monoclonal anti-Thy-1 antibody disulfide linked to the ribosome-inactivating protein gelonin.
  Scott, C. F., Goldmacher, V. S., Lambert, J. M., Chari, R. V., Bolender, S., Gauthier, M. N., Blättler, W. A.> ;Cancer Immunol Immunother. 1987
• Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability.
  Oroudjev, E., Lopus, M., Wilson, L., Audette, C., Provenzano, C., Erickson, H., Kovtun, Y., Chari, R., Jordan, M. A.> ;Mol Cancer Ther. 2010 Oct
• Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules.
  Lopus, M., Oroudjev, E., Wilson, L., Wilhelm, S., Widdison, W., Chari, R., Jordan, M. A.> ;Mol Cancer Ther. 2010 Oct
• Folate-maytansinoids: target-selective drugs of low molecular weight.
  Ladino, C. A., Chari, R. V., Bourret, L. A., Kedersha, N. L., Goldmacher, V. S.> ;Int J Cancer. 1997 Dec 10
• Eradication of large colon tumor xenografts by targeted delivery of maytansinoids.
  Liu, C., Tadayoni, B. M., Bourret, L. A., Mattocks, K. M., Derr, S. M., Widdison, W. C., Kedersha, N. L., Ariniello, P. D., Goldmacher, V. S., Lambert, J. M., Blättler...> ;Proc Natl Acad Sci U S A. 1996 Aug 6
• Immunoconjugates containing novel maytansinoids: promising anticancer drugs.
  Chari, R. V., Martell, B. A., Gross, J. L., Cook, S. B., Shah, S. A., Blättler, W. A., McKenzie, S. J., Goldmacher, V. S.> ;Cancer Res. 1992 Jan 1
• Enhancement of the selectivity and antitumor efficacy of a CC-1065 analogue through immunoconjugate formation.
  Chari, R. V., Jackel, K. A., Bourret, L. A., Derr, S. M., Tadayoni, B. M., Mattocks, K. M., Shah, S. A., Liu, C., Blättler, W. A., Goldmacher, V. S.> ;Cancer Res. 1995 Sep 15
• Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer.
  Zhao, R. Y., Erickson, H. K., Leece, B. A., Reid, E. E., Goldmacher, V. S., Lambert, J. M., Chari, R. V.> ;J Med Chem. 2012 Jan 26
• A novel pathway for maytansinoid release from thioether linked antibody-drug conjugates (ADCs) under oxidative conditions.
  Fishkin, N., Maloney, E. K., Chari, R. V., Singh, R.> ;Chem Commun (Camb). 2011 Oct 14
• Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates.
  Zhao, R. Y., Wilhelm, S. D., Audette, C., Jones, G., Leece, B. A., Lazar, A. C., Goldmacher, V. S., Singh, R., Kovtun, Y., Widdison, W. C., Lambert, J. M., Chari, R. V.> ;J Med Chem. 2011 May 26
• Disulfide-linked antibody-maytansinoid conjugates: optimization of in vivo activity by varying the steric hindrance at carbon atoms adjacent to the disulfide linkage.
  Kellogg, B. A., Garrett, L., Kovtun, Y., Lai, K. C., Leece, B., Miller, M., Payne, G., Steeves, R., Whiteman, K. R., Widdison, W., Xie, H., Singh, R., Chari, R. V., La...> ;Bioconjug Chem. 2011 Apr 20
• Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study.
  Tolcher, A. W., Ochoa, L., Hammond, L. A., Patnaik, A., Edwards, T., Takimoto, C., Smith, L., de Bono, J., Schwartz, G., Mays, T., Jonak, Z. L., Johnson, R., DeWitte, ...> ;J Clin Oncol. 2003 Jan 15
• Tumor-specific novel taxoid-monoclonal antibody conjugates.
  Ojima, I., Geng, X., Wu, X., Qu, C., Borella, C. P., Xie, H., Wilhelm, S. D., Leece, B. A., Bartle, L. M., Goldmacher, V. S., Chari, R. V.> ;J Med Chem. 2002 Dec 19
• Antibody-maytansinoid conjugates designed to bypass multidrug resistance.
  Kovtun, Y. V., Audette, C. A., Mayo, M. F., Jones, G. E., Doherty, H., Maloney, E. K., Erickson, H. K., Sun, X., Wilhelm, S., Ab, O., Lai, K. C., Widdison, W. C., Kell...> ;Cancer Res. 2010 Mar 15
• Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate.
  Lewis Phillips, G. D., Li, G., Dugger, D. L., Crocker, L. M., Parsons, K. L., Mai, E., Blättler, W. A., Lambert, J. M., Chari, R. V., Lutz, R. J., Wong, W. L., Jacobso...> ;Cancer Res. 2008 Nov 15
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