SanthoshAUpadhyayaMD

PubMed

• Atypical teratoid/rhabdoid tumour-TYR subtype arising in the setting of germline ring chromosome 22: An uncommon form of tumour predisposition.
  Julieann C Lee, Quynh T Tran, Rose B McGee, Melissa R Perrino, Santhosh A Upadhyaya, Emily M Hanzlik, Nicholas Pytel, Andrew J Carroll, Wilda Orisme, Mohammad Eldomery...> ;Neuropathology and Applied Neurobiology. 2024 Apr 1
• 3 citations
  High-grade glioma in infants and young children is histologically, molecularly, and clinically diverse: Results from the SJYC07 trial and institutional experience.
  Chiang, J., Bagchi, A., Li, X., Dhanda, S., Huang, J., Pinto, S., Sioson, E., Dalton, J., Tatevossian, R., Jia, S., Partap, S., Fisher, P., Bowers, D., Hassall, T., Lu...> ;Neuro-Oncology. 2024 Jan 5
• 2 citations
  Clinical, genomic, and epigenomic analyses of H3K27M-mutant diffuse midline glioma long-term survivors reveal a distinct group of tumors with MAPK pathway alterations.
  Holly J Roberts, Sunjong Ji, Alberto Picca, Marc Sanson, Mekka Garcia, Matija Snuderl, Ulrich Schüller, Thiébaud Picart, François Ducray, Adam L Green, Yoshiko Nakano,...> ;Acta Neuropathologica. 2023 Dec 1
• 3 citations
  Phase II Trial of Dabrafenib Plus Trametinib in Relapsed/RefractoryV600-Mutant Pediatric High-Grade Glioma.
  Darren R Hargrave, Keita Terashima, Junichi Hara, Uwe R Kordes, Santhosh A Upadhyaya, Felix Sahm, Eric Bouffet, Roger J Packer, Olaf Witt, Larissa Sandalic, Agnieszka ...> ;Journal of Clinical Oncology. 2023 Nov 20
• Constitutional balanced translocations involving SMARCB1: A rare cause of rhabdoid tumor predisposition syndrome.
  Patrick R Blackburn, Rose B McGee, Roya Mostafavi, Andrew J Carroll, Fady M Mikhail, Gregory T Armstrong, Larissa V Furtado, Jason Chiang, David A Wheeler, Steven S Ca...> ;Genes, Chromosomes & Cancer. 2024 Jan 1
• DNA-methylation subgroups carry no prognostic significance in ATRT-SHH patients in clinical trial cohorts.
  Quynh T Tran, Santhosh A Upadhyaya, Catherine A Billups, Arzu Onar-Thomas, Md Zahangir Alom, Steven S Carey, Giles W Robinson, David W Ellison, Amar Gajjar, Brent A Orr> ;Acta Neuropathologica. 2023 Sep 1
• 5 citations
  Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities.
  Irene Paassen, Justin Williams, Carla Ríos Arceo, Femke Ringnalda, Kimberly Shea Mercer, Juliane L Buhl, Natalia Moreno, Aniello Federico, Niels E Franke, Mariette Kra...> ;Oncogene. 2023 May 1
• 6 citations
  Molecular classification and outcome of children with rare CNS embryonal tumors: results from St. Jude Children's Research Hospital including the multi-center SJYC07 a...
  Anthony P Y Liu, Sandeep K Dhanda, Tong Lin, Edgar Sioson, Aksana Vasilyeva, Brian Gudenas, Ruth G Tatevossian, Sujuan Jia, Geoffrey Neale, Daniel C Bowers, Tim Hassal...> ;Acta Neuropathologica. 2022 Oct 1
• 1 citations
  Reducing Wait Time in a High-volume Pediatric Neuro-oncology Clinic by Optimizing Process Flow: A Quality Improvement Project.
  Anna Vinitsky, Barbara David, Layna Michalik, Nicole Ramirez, Adam Risinger, Jonathan D Burlison, Jacky Zanders, Bridget Mans, Katie Heady, Joni Holdiness, Ibrahim Qad...> ;Pediatric Quality & Safety. 2022 Jun 14
• 7 citations
  Phase II study of alisertib as a single agent for treating recurrent or progressive atypical teratoid/rhabdoid tumor.
  Santhosh A Upadhyaya, Olivia Campagne, Catherine A Billups, Brent A Orr, Arzu Onar-Thomas, Ruth G Tatevossian, Roya Mostafavi, Jason R Myers, Anna Vinitsky, Daniel C M...> ;Neuro-Oncology. 2023 Feb 14
• 13 citations
  NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.
  Yiannis Drosos, Jacquelyn A Myers, Beisi Xu, Kaeli M Mathias, Emma C Beane, Sandi Radko-Juettner, Robert J Mobley, Margaret E Larsen, Federica Piccioni, Xiaotu Ma, Jon...> ;Molecular Cell. 2022 Jul 7
• 19 citations
  Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma
  Chen He, Ke Xu, Xiaoyan Zhu, Paige S. Dunphy, Brian Gudenas, Wenwei Lin, Nathaniel R. Twarog, Laura D. Hover, Chang-Hyuk Kwon, Lawryn H. Kasper, Junyuan Zhang, Xiaoyu ...> ;Nature Communications. 2021 Jul 2
• 1 citations
  A rare manifestation of choriocarcinoma syndrome in a child with primary intracranial germ cell tumor and extracranial metastases: A case report and review of the lite...
  Camille Keenan, Nicole Ramirez, Lucas Elijovich, Paul Klimo, Asim K. Bag, Sahaja Acharya, Santhosh A. Upadhyaya> ;Pediatric Blood & Cancer. 2021 Apr 5
• 28 citations
  Relevance of Molecular Groups in Children with Newly Diagnosed Atypical Teratoid Rhabdoid Tumor: Results from Prospective St. Jude Multi-institutional Trials
  Santhosh A. Upadhyaya, Giles W. Robinson, Arzu Onar-Thomas, Brent A. Orr, Pascal Johann, Gang Wu, Catherine A. Billups, Ruth G. Tatevossian, Sandeep Kumar Dhanda, Asho...> ;Clinical Cancer Research. 2021 Mar 18
• 35 citations
  Atypical teratoid/rhabdoid tumors (ATRTs) with SMARCA4 mutation are molecularly distinct from SMARCB1-deficient cases.
  Dörthe Holdhof, Pascal Johann, Michael Spohn, Michael Bockmayr, Sepehr Safaei, Piyush Joshi, Julien Masliah-Planchon, Ben Ho, Mamy Andrianteranagna, Franck Bourdeaut, ...> ;Acta Neuropathologica. 2021 Feb 1
• 1 citations
  Comment on: Response to the BRAF/MEK inhibitors dabrafenib/trametinib in an adolescent with a BRAF V600E mutated anaplastic ganglioglioma intolerant to vemurafenib
  Melissa S Bourque, Noah D. Sabin, Meredith Canale, Santhosh A. Upadhyaya, Marta Salek> ;Pediatric Blood & Cancer. 2021 Apr 1
• 13 citations
  Infratentorial C11orf95-fused gliomas share histologic, immunophenotypic, and molecular characteristics of supratentorial RELA-fused ependymoma
  Camille Keenan, Richard T Graham, Julie H. Harreld, John T. Lucas, David Finkelstein, David A. Wheeler, Xiaoyu Li, James Dalton, Santhosh A. Upadhyaya, Susana C. Raimo...> ;Acta Neuropathologica. 2020 Oct 24
• 2 citations
  Relevance of the Type and Timing of Radiation Therapy to the Outcomes Reported in the ACNS0333 Trial for Atypical Teratoid/Rhabdoid Tumors
  Santhosh A. Upadhyaya> ;Journal of Clinical Oncology. 2020 Jul 30
• 1 citations
  Treatment-related calvarial lesions in pediatric brain tumor survivors.
  David Wallace, Douglas R. Taylor, Haitao Pan, Scott N. Hwang, John T. Lucas, Paul Klimo, Santhosh A. Upadhyaya, Frederick A. Boop> ;Pediatric Blood & Cancer. 2020 Apr 14
• 2 citations
  Handedness switching as a presenting sign for pediatric low-grade gliomas: An insight into brain plasticity from a short case series.
  Yahya Ghazwani, Zoltan Patay, Zsila S. Sadighi, Jessica Sparrow, Santhosh A. Upadhyaya, Frederick A. Boop, Amar Gajjar, Ibrahim Qaddoumi> ;Journal of Pediatric Rehabilitation Medicine. 2021 Jan 1
• 51 citations
  Molecular grouping and outcomes of young children with newly diagnosed ependymoma treated on the multi-institutional SJYC07 trial
  Santhosh A. Upadhyaya, Giles W. Robinson, Arzu Onar-Thomas, Brent A. Orr, Catherine A. Billups, Daniel C. Bowers, Anne Bendel, Tim Hassall, John R. Crawford, Sonia Par...> ;Neuro-Oncology. 2019 Oct 9
• 3 citations
  From uncertainty to pathogenicity: clinical and functional interrogation of a rare TP53 in-frame deletion.
  Emily Quinn, Jamie L. Maciaszek, Emilia M. Pinto, Aaron H. Phillips, David Berdy, Mohammad Khandwala, Santhosh A. Upadhyaya, Gerard P. Zambetti, Richard W. Kriwacki, D...> ;Cold Spring Harbor Molecular Case Studies. 2019 Aug 1
• 8 citations
  Chromosome arm 1q gain is an adverse prognostic factor in localized and diffuse leptomeningeal glioneuronal tumors with BRAF gene fusion and 1p deletion.
  Jason Chiang, James Dalton, Santhosh A. Upadhyaya, Zoltan Patay, Ibrahim Qaddoumi, Xiaoyu Li, Annette D. Segura, Suash Sharma, Azzam Ismail, Sheila A. Shurtleff, Susan...> ;Acta Neuropathologica. 2019 Jan 1
• 4 citations
  Anaplastic Astrocytoma in a Child With Coffin-Siris Syndrome and a Germline SMARCE1 Mutation: A Case Report.
  Beryl Lin, Chimene Kesserwan, Emily Quinn, Stephanie L. Einhaus, Karen Wright, Elizabeth M Azzato, Brent A. Orr, Santhosh A. Upadhyaya> ;Journal of Pediatric Hematology/oncology. 2020 Apr 1
• Clinical Implications of Real-time Integrative Sequencing in Management of Patients With Suspected Germline BAP1 Mutations.
  Shayan Sengupta, Angela C. Weyand, Santhosh A. Upadhyaya, Yi-Mi Wu, Dan R. Robinson, Rajen Mody> ;Journal of Pediatric Hematology/oncology. 2019 May 1
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Lectures

• Outcomes for young children with molecularly defined ependymoma treated on the multi-institutional SJYC07 clinical trial. 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/2/2018