ScottHKaufmannMDPhD

PubMed

• A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia.
  Guru Subramanian Guru Murthy, Antoine N Saliba, Aniko Szabo, Alexandra Harrington, Sameem Abedin, Karen Carlson, Laura Michaelis, Lyndsey Runaas, Arielle Baim, Alex Hi...> ;Haematologica. 2024 Apr 4
• AMPK inhibition sensitizes acute leukemia cells to BH3 mimetic-induced cell death.
  Jia Jia, Wenbo Ji, Antoine N Saliba, Clifford M Csizmar, Kaiqin Ye, Lei Hu, Kevin L Peterson, Paula A Schneider, X Wei Meng, Annapoorna Venkatachalam, Mrinal M Patnaik...> ;Cell Death and Differentiation. 2024 Mar 27
• Phase 1 trial of navitoclax and sorafenib in patients with relapsed or refractory solid tumors with hepatocellular carcinoma expansion cohort.
  Emiloju, O., Yin, J., Koubek, E., Reid, J., Borad, M., Lou, Y., Seetharam, M., Edelman, M., Sausville, E., Jiang, Y., Kaseb, A., Posey, J., Davis, S., Gores, G., Rober...> ;Investigational New Drugs. 2024 Feb 1
• 1 citations
  Author Correction: Apoptotic stress causes mtDNA release during senescence and drives the SASP.
  Victorelli, S., Salmonowicz, H., Chapman, J., Martini, H., Vizioli, M., Riley, J., Cloix, C., Hall-Younger, E., Machado Espindola-Netto, J., Jurk, D., Lagnado, A., Sal...> ;Nature. 2024 Jan 1
• Endoxifen downregulates AKT phosphorylation through protein kinase C beta 1 inhibition in ERα+ breast cancer.
  Jayaraman, S., Wu, X., Kalari, K., Tang, X., Kuffel, M., Bruinsma, E., Jalali, S., Peterson, K., Correia, C., Kudgus, R., Kaufmann, S., Renuse, S., Ingle, J., Reid, J....> ;NPJ Breast Cancer. 2023 Dec 19
• 1 citations
  A phase 2 and pharmacological study of sapanisertib in patients with relapsed and/or refractory acute lymphoblastic leukemia.
  Aref Al-Kali, Ibrahim Aldoss, Pamela J Atherton, Carrie A Strand, Bijal Shah, Jonathan Webster, Bhavana Bhatnagar, Karen S Flatten, Kevin L Peterson, Paula A Schneider...> ;Cancer Medicine. 2023 Dec 1
• Concurrent RB1 loss and-deficiency predicts enhanced immunological response and long-term survival in tubo-ovarian high-grade serous carcinoma.
  Flurina A M Saner, Kazuaki Takahashi, Timothy Budden, Ahwan Pandey, Dinuka Ariyaratne, Tibor A Zwimpfer, Nicola S Meagher, Sian Fereday, Laura Twomey, Kathleen I Pisha...> ;Medrxiv. 2023 Nov 10
• 24 citations
  Apoptotic stress causes mtDNA release during senescence and drives the SASP.
  Stella Victorelli, Hanna Salmonowicz, James Chapman, Helene Martini, Maria Grazia Vizioli, Joel S Riley, Catherine Cloix, Ella Hall-Younger, Jair Machado Espindola-Net...> ;Nature. 2023 Oct 1
• PG545 sensitizes ovarian cancer cells to PARP inhibitors through modulation of RAD51-DEK interaction.
  Upasana Ray, Prabhu Thirusangu, Ling Jin, Yinan Xiao, Christopher L Pathoulas, Julie Staub, Courtney L Erskine, Keith Dredge, Edward Hammond, Matthew S Block, Scott H ...> ;Oncogene. 2023 Sep 1
• 4 citations
  Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer.
  Shrabanti Chowdhury, Jacob J Kennedy, Richard G Ivey, Oscar D Murillo, Noshad Hosseini, Xiaoyu Song, Francesca Petralia, Anna Calinawan, Sara R Savage, Anna B Berry, B...> ;Cell. 2023 Aug 3
• Eltrombopag directly activates BAK and induces apoptosis.
  Meng Chen, Lei Hu, Xuyuan Bao, Kaiqin Ye, Yunjian Li, Zhiyong Zhang, Scott H Kaufmann, Jun Xiao, Haiming Dai> ;Cell Death & Disease. 2023 Jul 1
• How CHKing ROS signaling preserves genomic integrity.
  Annapoorna Venkatachalam, Scott H Kaufmann> ;Cell Research. 2023 Nov 1
• 1 citations
  Relationship between BCL2 mutations and follicular lymphoma outcome in the chemoimmunotherapy era.
  Cristina Correia, Matthew J Maurer, Samantha J McDonough, Paula A Schneider, Paige E Ross, Anne J Novak, Andrew L Feldman, James R Cerhan, Susan L Slager, Thomas E Wit...> ;Blood Cancer Journal. 2023 May 17
• 12 citations
  Diagnostic and prognostic potential of the microbiome in ovarian cancer treatment response.
  Abigail E Asangba, Jun Chen, Krista M Goergen, Melissa C Larson, Ann L Oberg, Jvan Casarin, Francesco Multinu, Scott H Kaufmann, Andrea Mariani, Nicholas Chia, Marina ...> ;Scientific Reports. 2023 Jan 13
• 6 citations
  CCNE1 and survival of patients with tubo-ovarian high-grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study.
  Eun-Young Kang, Ashley Weir, Nicola S Meagher, Kyo Farrington, Gregg S Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J Riggan, Adelyn Bolithon, Gordana Popovic, Bet...> ;Cancer. 2023 Mar 1
• 2 citations
  A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C.
  Haiming Dai, Kevin L Peterson, Karen S Flatten, X Wei Meng, Annapoorna Venkatachalam, Cristina Correia, Marina Ramirez-Alvarado, Yuan-Ping Pang, Scott H Kaufmann> ;Cell Death and Differentiation. 2023 Mar 1
• 4 citations
  Pevonedistat with azacitidine in older patients with TP53-mutated AML: a phase 2 study with laboratory correlates.
  Antoine N Saliba, Scott H Kaufmann, Eytan M Stein, Prapti A Patel, Maria R Baer, Wendy Stock, Michael Deininger, William Blum, Gary J Schiller, Rebecca L Olin, Mark R ...> ;Blood Advances. 2023 Jun 13
• 12 citations
  Homologous recombination-deficient mutation cluster in tumor suppressoridentified by comprehensive analysis of cancer variants.
  Rohit Prakash, Yashpal Rawal, Meghan R Sullivan, McKenzie K Grundy, Hélène Bret, Michael J Mihalevic, Hayley L Rein, Jared M Baird, Kristie Darrah, Fang Zhang, Raymond...> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Sep 20
• 2 citations
  DAGBagM: learning directed acyclic graphs of mixed variables with an application to identify protein biomarkers for treatment response in ovarian cancer.
  Shrabanti Chowdhury, Ru Wang, Qing Yu, Catherine J Huntoon, Larry M Karnitz, Scott H Kaufmann, Steven P Gygi, Michael J Birrer, Amanda G Paulovich, Jie Peng, Pei Wang> ;BMC Bioinformatics. 2022 Aug 5
• Machine-learning aided in situ drug sensitivity screening predicts treatment outcomes in ovarian PDX tumors.
  Max J Cotler, Khalil B Ramadi, Xiaonan Hou, Elena Christodoulopoulos, Sebastian Ahn, Ashvin Bashyam, Huiming Ding, Melissa Larson, Ann L Oberg, Charles Whittaker, Oliv...> ;Translational Oncology. 2022 Jul 1
• 5 citations
  A phase 1 and pharmacodynamic study of chronically-dosed, single-agent veliparib (ABT-888) in patients with BRCA1- or BRCA2-mutated cancer or platinum-refractory ovari...
  Julia Manzo, Shannon Puhalla, Shalu Pahuja, Fei Ding, Yan Lin, Leonard Appleman, Hussein Tawbi, Ronald Stoller, James J Lee, Brenda Diergaarde, Brian F Kiesel, Jing Yu...> ;Cancer Chemotherapy and Pharmacology. 2022 May 1
• Correction: High cell surface death receptor expression determines type I versus type II signaling.
  Xue Wei Meng, Kevin L Peterson, Haiming Dai, Paula Schneider, Sun-Hee Lee, Jin-San Zhang, Alexander Koenig, Steve Bronk, Daniel D Billadeau, Gregory J Gores, Scott H K...> ;The Journal of Biological Chemistry. 2022 May 1
• 15 citations
  Impact of homologous recombination status and responses with veliparib combined with first-line chemotherapy in ovarian cancer in the Phase 3 VELIA/GOG-3005 study.
  Elizabeth M Swisher, Carol Aghajanian, David M O'Malley, Gini F Fleming, Scott H Kaufmann, Douglas A Levine, Michael J Birrer, Kathleen N Moore, Nick M Spirtos, Mark S...> ;Gynecologic Oncology. 2022 Feb 1
• 7 citations
  Uncovering Pharmacological Opportunities for Cancer Stem Cells-A Systems Biology View.
  Cristina Correia, Taylor M Weiskittel, Choong Yong Ung, Jose C Villasboas Bisneto, Daniel D Billadeau, Scott H Kaufmann, Hu Li> ;Frontiers in Cell and Developmental Biology. 2022 Jan 1
• 23 citations
  Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer.
  Dongqing Huang, Shrabanti Chowdhury, Hong Wang, Sara R Savage, Richard G Ivey, Jacob J Kennedy, Jeffrey R Whiteaker, Chenwei Lin, Xiaonan Hou, Ann L Oberg, Melissa C L...> ;Cell Reports. Medicine. 2021 Dec 21
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Journal Articles

• Methylation of All BRCA1 Copies Predicts Response to the PARP Inhibitor Rucaparib in Ovarian Carcinoma  
  Scott H Kaufmann, Elizabeth M Swisher, Nature

Abstracts/Posters

• A Multisite Phase Ib Study of Pevonedistat, Azacitidine and Venetoclax (PAVE) for the Treatment of Subjects with Acute Myelogenous Leukemia (AML)
  Scott H. Kaufmann, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Clinical Categorization of Chronic Myelomonocytic Leukemia into Proliferative and Dysplastic Subtypes Correlates with Distinct Genomic, Transcriptomic and Epigenomic S...
  Scott H. Kaufmann, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019