WilliamGeorgeNelsonMD

Professor of Oncology, Professor of Medicine, Professor of Pathology, Professor of Radiation Oncology and Molecular Radiation Sciences, Professor of Urology, Johns Hopkins University School of Medicine; Director, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Marion I. Knott Professor of Oncology

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Office
401 N. Broadway
Baltimore, MD 21231
Phone+1 410-955-8964
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Education & Training

Johns Hopkins UniversityFellowship, Hematology and Medical Oncology, 1989 - 1992
Johns Hopkins UniversityResidency, Internal Medicine, 1987 - 1989
Johns Hopkins University School of MedicineClass of 1987

Certifications & Licensure

MD State Medical License 1990 - 2025

Publications & Presentations

PubMed

Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer.
Joakin O Mori, Isra Elhussin, W Nathaniel Brennen, Mindy K Graham, Tamara L Lotan, Clayton C Yates, Angelo M De Marzo, Samuel R Denmeade, Srinivasan Yegnasubramanian, ...> ;Nature Reviews. Urology. 2023 Oct 31
2 citations
Progressive Spreading of DNA Methylation in the GSTP1 Promoter CpG Island across Transitions from Precursors to Invasive Prostate Cancer.
Harshath Gupta, Hitoshi Inoue, Yasutomo Nakai, Masashi Nakayama, Tracy Jones, Jessica L Hicks, Balasubramanian Kumar, Meltem Gurel, William G Nelson, Angelo M De Marzo...> ;Cancer Prevention Research. 2023 Aug 1
2 citations
Single-cell atlas of epithelial and stromal cell heterogeneity by lobe and strain in the mouse prostate.
Mindy K Graham, Roshan Chikarmane, Rulin Wang, Ajay Vaghasia, Anuj Gupta, Qizhi Zheng, Bulouere Wodu, Xin Pan, Nicole Castagna, Jianyong Liu, Jennifer Meyers, Alyza Sk...> ;The Prostate. 2023 Feb 1
2 citations
Genomic Characterization of Prostatic Basal Cell Carcinoma.
Jin-Yih Low, Minjeong Ko, Brian Hanratty, Radhika A Patel, Akshay Bhamidipati, Christopher M Heaphy, Erolcan Sayar, John K Lee, Shan Li, Angelo M De Marzo, William G N...> ;The American Journal of Pathology. 2023 Jan 1
1 citations
Identifying Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole-Genome Sequencing.
Minh-Tam Pham, Anuj Gupta, Harshath Gupta, Ajay Vaghasia, Alyza Skaist, McKinzie A Garrison, Jonathan B Coulter, Michael C Haffner, S Lilly Zheng, Jianfeng Xu, Christi...> ;Molecular Cancer Research. 2022 Jul 6
3 citations
Hormonal patterns in men with prediabetes and diabetes in NHANES III: possible links with prostate cancer.
Kerri Beckmann, Danielle Crawley, William G Nelson, Elizabeth A Platz, Elizabeth Selvin, Mieke Van Hemelrijck, Sabine Rohrmann> ;Cancer Causes & Control. 2022 Mar 1
7 citations
Phenotypic characterization of two novel cell line models of castration-resistant prostate cancer.
Michael C. Haffner, Akshay Bhamidipati, Harrison Tsai, David M. Esopi, Ajay Vaghasia, Jin-Yih Low, Radhika A. Patel, Gunes Guner, Minh-Tam Pham, Nicole Castagna, Jessi...> ;The Prostate. 2021 Aug 16
10 citations
GSTP1 positive prostatic adenocarcinomas are more common in Black than White men in the United States
Igor Vidal, Qizhi Zheng, Jessica L. Hicks, Jiayu Chen, Elizabeth A. Platz, Bruce J. Trock, Ibrahim Kulac, Javier Valle, Karen S. Sfanos, Sarah E. Ernst, Tracy Jones, J...> ;Plos One. 2021 Jun 30
23 citations
Resistance to androgen receptor signaling inhibition does not necessitate development of neuroendocrine prostate cancer
W. Nathaniel Brennen, Yezi Zhu, Ilsa Coleman, Susan L. Dalrymple, Lizamma Antony, Radhika A. Patel, Brian Hanratty, Roshan Chikarmane, Alan K. Meeker, S. Lilly Zheng, ...> ;JCI Insight. 2021 Apr 22
7 citations
Epigenetic and transcriptional analysis reveals a core transcriptional program conserved in clonal prostate cancer metastases
Tesa M. Severson, Yanyun Zhu, Angelo M. De Marzo, Tracy Jones, Jonathan W. Simons, William G. Nelson, Srinivasan Yegnasubramanian, Matthew L. Freedman, Lodewyk F. A. W...> ;Molecular Oncology. 2021 Jul 1
179 citations
Genomic and phenotypic heterogeneity in prostate cancer.
Michael C. Haffner, Wilbert Zwart, Martine Roudier, Lawrence D. True, William G. Nelson, Jonathan I. Epstein, Angelo M. De Marzo, Peter S. Nelson, Srinivasan Yegnasubr...> ;Nature Reviews. Urology. 2021 Feb 1
28 citations
The association of sex steroid hormone concentrations with non-alcoholic fatty liver disease and liver enzymes in US men
Hong Phan, Aline Richard, Mariana Lazo, William G. Nelson, Samuel R. Denmeade, John D. Groopman, Norma Kanarek, Elizabeth A. Platz, Sabine Rohrmann> ;Liver International. 2021 Feb 1
2 citations
Association of Serum Carotenoids and Retinoids with Intraprostatic Inflammation in Men without Prostate Cancer or Clinical Indication for Biopsy in the Placebo Arm of ...
Susan Chadid, Xiaoling Song, Jeannette M. Schenk, Bora Gurel, M. Scott Lucia, Ian M. Thompson, Marian L. Neuhouser, Phyllis J. Goodman, Howard L. Parnes, Scott M. Lipp...> ;Nutrition and Cancer. 2021 Jan 29
3 citations
Effects of High-Fructose Diet vs . Teklad Diet in the MNU-Induced Rat Mammary Cancer Model: Altered Tumorigenesis, Metabolomics and Tumor RNA Expression.
Amit Kumar, Ronald A. Lubet, Jennifer T. Fox, William G. Nelson, Harold E. Seifried, Clinton J. Grubbs, Mark Steven Miller> ;Journal of Obesity and Chronic Diseases. 2021 Jan 11
7 citations
Use of Aspirin and Statins in Relation to Inflammation in Benign Prostate Tissue in the Placebo Arm of the Prostate Cancer Prevention Trial.
Lauren M. Hurwitz, Ibrahim Kulac, Berrak Gumuskaya, Javier A. Baena Del Valle, Ines Benedetti, Fan Pan, Jun O. Liu, Michael T. Marrone, Kathryn B. Arnold, Phyllis J. G...> ;Cancer Prevention Research. 2020 Jun 24
The association between serum sex steroid hormone concentrations and intraprostatic inflammation in men without prostate cancer and irrespective of clinical indication...
Susan Chadid, John R. Barber, William G. Nelson, Bora Gurel, M. Scott Lucia, Ian M. Thompson, Phyllis J. Goodman, Frank Z. Stanczyk, Howard L. Parnes, Scott M. Lippman...> ;The Prostate. 2020 Aug 1
9 citations
Pervasive promoter hypermethylation of silenced TERT alleles in human cancers
David M. Esopi, Mindy K. Graham, Jacqueline A. Brosnan-Cashman, Jennifer Meyers, Ajay Vaghasia, Anuj Gupta, Binod Kumar, Michael C. Haffner, Christopher M. Heaphy, A. ...> ;Cellular Oncology. 2020 May 28
5 citations
Age-Specific Serum Total and Free Estradiol Concentrations in Healthy Men in US Nationally Representative Samples.
Susan Chadid, John R. Barber, Sabine Rohrmann, William G. Nelson, James D. Yager, Norma Kanarek, Gary Bradwin, Adrian S. Dobs, Katherine A. McGlynn, Elizabeth A. Platz> ;Journal of the Endocrine Society. 2019 Jul 19
10 citations
Trichomonas vaginalis infection and prostate‐specific antigen concentration: Insights into prostate involvement and prostate disease risk
Marvin E. Langston, Ankita Bhalla, John F. Alderete, Remington L. Nevin, Ratna Pakpahan, Johannah Hansen, Debra J. Elliott, Angelo M. De Marzo, Charlotte A. Gaydos, Wi...> ;The Prostate. 2019 Aug 2
7 citations
Nationally Representative Estimates of Serum Testosterone Concentration in Never-Smoking, Lean Men Without Aging-Associated Comorbidities.
Elizabeth A. Platz, John R. Barber, Susan Chadid, Jiayun Lu, Adrian S. Dobs, Norma Kanarek, William G. Nelson, Gary Bradwin, Katherine A. McGlynn, Sabine Rohrmann> ;Journal of the Endocrine Society. 2019 Jul 3
11 citations
A high-throughput screen of pharmacologically active compounds for inhibitors of UHRF1 reveals epigenetic activity of anthracycline derivative chemotherapeutic drugs.
Hugh Giovinazzo, David Walker, Nicolas Wyhs, Jianyong Liu, David M. Esopi, Ajay Vaghasia, Yash Jain, Akshay Bhamidipati, Jianya Zhou, William G. Nelson, Srinivasan Yeg...> ;Oncotarget. 2019 Apr 30
20 citations
Prostate Cancer Epigenetics: From Basic Mechanisms to Clinical Implications
Srinivasan Yegnasubramanian, Angelo M. De Marzo, William G. Nelson> ;Cold Spring Harbor Perspectives in Medicine. 2019 Apr 1
1 citations
Selenium and Sex Steroid Hormones in a U.S. Nationally Representative Sample of Men: A Role for the Link between Selenium and Estradiol in Prostate Carcinogenesis?
Mieke Van Hemelrijck, Sam Sollie, William G. Nelson, James D. Yager, Norma Kanarek, Adrian S. Dobs, Elizabeth A. Platz, Sabine Rohrmann> ;Cancer Epidemiology, Biomarkers & Prevention. 2019 Mar 1
17 citations
If this is true, what does it imply? How end-user antibody validation facilitates insights into biology and disease
Karen S. Sfanos, Srinivasan Yegnasubramanian, William G. Nelson, Tamara L. Lotan, Ibrahim Kulac, Jessica L. Hicks, Qizhi Zheng, Charles J. Bieberich, Michael C. Haffne...> ;Asian Journal of Urology. 2019 Jan 1
8 citations
Association between Liver Fibrosis and Serum PSA among U.S. Men: National Health and Nutrition Examination Survey (NHANES), 2001-2010.
Anqi Wang, Mariana Lazo, H. Ballentine Carter, John D. Groopman, William G. Nelson, Elizabeth A. Platz> ;Cancer Epidemiology, Biomarkers & Prevention. 2019 Jan 1
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Journal Articles

Sustained Influence of Infections on Prostate‐Specific Antigen Concentration: An Analysis of Changes over 10 Years of Follow‐Up
Remington L Nevin, William G Nelson, Elizabeth A Platz, Jonathan M Zenilman, The Prostate

Press Mentions

V Foundation Wine Celebration Raises Millions to Support Cancer ResearchAugust 14th, 2021
Johns Hopkins Medicine Celebrates Opening of the Johns Hopkins National Proton Center at Sibley Memorial Hospital, in Collaboration with Children’s NationalOctober 28th, 2019
DNA Can Point the Way Toward Curing or Controlling CancerJune 27th, 2019
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