ArthurBeyderMDPhD

PubMed

• Circadian rhythm and whole gut transit in mice.
  Emma Laible, Andrew Wegner, Kaitlyn Knutson, Halil Kacmaz, Gwyneth K Garramone, Kamalika Gogineni, Aleksey Matveyenko, David R Linden, Gianrico Farrugia, Arthur Beyder> ;Neurogastroenterology and Motility. 2024 Apr 1
• Stretch response of the mechano-gated channel TMEM63A in membrane patches and single cells.
  Niloy, S., Strege, P., Hannan, E., Cowan, L., Linsenmeier, F., Friedrich, O., Farrugia, G., Beyder, A.> ;American Journal of Physiology. Cell Physiology. 2024 Feb 1
• Modeling Gut Neuro-Epithelial Connections in a Novel Micro uidic Device.
  Manolo De Hoyos, Xi Yu, Alan Gonzalez-Suarez, Arnaldo Mercado-Perez, Eugene Krueger, Jeric Hernandez, Brooke Druliner, David R Linden, Arthur Beyder, Sisi Chen, Yarosl...> ;Research Square. 2023 Sep 7
• 14 citations
  PIEZO2 in somatosensory neurons controls gastrointestinal transit.
  M Rocio Servin-Vences, Ruby M Lam, Alize Koolen, Yu Wang, Dimah N Saade, Meaghan Loud, Halil Kacmaz, Suzanne Frausto, Yunxiao Zhang, Arthur Beyder, Kara L Marshall, Ca...> ;Cell. 2023 Aug 3
• Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel.
  Peter R Strege, Luke M Cowan, Constanza Alcaino, Amelia Mazzone, Christopher A Ahern, Lorin S Milescu, Gianrico Farrugia, Arthur Beyder> ;Elife. 2023 Mar 13
• Tracking Gut Motility in Organ and Cultures.
  Peng Du, Vikram Joshi, Arthur Beyder> ;Methods in Molecular Biology. 2023 Jan 1
• 3 citations
  Capsaicin as an amphipathic modulator of Na1.5 mechanosensitivity.
  Luke M Cowan, Peter R Strege, Radda Rusinova, Olaf S Andersen, Gianrico Farrugia, Arthur Beyder> ;Channels. 2022 Dec 1
• 4 citations
  Intestinal enteroendocrine cells rely on ryanodine and IPcalcium store receptors for mechanotransduction.
  Kaitlyn R Knutson, Sara T Whiteman, Constanza Alcaino, Arnaldo Mercado-Perez, Isabelle Finholm, Hannah K Serlin, Shreya S Bellampalli, David R Linden, Gianrico Farrugi...> ;The Journal of Physiology. 2023 Jan 1
• 3 citations
  Localized bioelectrical conduction block from radiofrequency gastric ablation persists after healing: safety and feasibility in a recovery model.
  Zahra Aghababaie, Gregory O'Grady, Linley A Nisbet, Andre E Modesto, Chih-Hsiang Alexander Chan, Ashton Matthee, Satya Amirapu, Arthur Beyder, Gianrico Farrugia, Samue...> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2022 Dec 1
• 8 citations
  Mechano-Sensing Channel PIEZO2 Enhances Invasive Phenotype in Triple-Negative Breast Cancer.
  Eriko Katsuta, Kazuaki Takabe, Marija Vujcic, Philip A Gottlieb, Tao Dai, Arnaldo Mercado-Perez, Arthur Beyder, Qingfei Wang, Mateusz Opyrchal> ;International Journal of Molecular Sciences. 2022 Aug 31
• LEtS set the tone.
  Vikram Joshi, Arthur Beyder> ;The Journal of Physiology. 2022 Jun 1
• 42 citations
  Gut feelings: mechanosensing in the gastrointestinal tract.
  Arnaldo Mercado-Perez, Arthur Beyder> ;Nature Reviews. Gastroenterology & Hepatology. 2022 May 1
• 8 citations
  Targeted ablation of gastric pacemaker sites to modulate patterns of bioelectrical slow wave activation and propagation in an anesthetized pig model.
  Zahra Aghababaie, Leo K Cheng, Niranchan Paskaranandavadivel, Recep Avci, Chih-Hsiang Alexander Chan, Ashton Matthee, Satya Amirapu, Samuel J Asirvatham, Gianrico Farr...> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2022 Apr 1
• Studying Murine Small Bowel Mechanosensing of Luminal Particulates.
  Arnaldo Mercado-Perez, Andrew Wegner, Kaitlyn Knutson, Michael Zumchak, Arthur Beyder> ;Journal of Visualized Experiments. 2022 Mar 18
• 31 citations
  Specialized mechanosensory epithelial cells in mouse gut intrinsic tactile sensitivity
  Anthony J. Treichel, Isabelle W. Finholm, Kaitlyn R. Knutson, Constanza Alcaino, Sara T. Whiteman, Matthew R. Brown, Aleksey V. Matveyenko, Andrew J. Wegner, Halil Kac...> ;Gastroenterology. 2021 Oct 22
• 17 citations
  Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease
  Tenghao Zheng, David Ellinghaus, Simonas Juzenas, François Cossais, Greta Burmeister, Gabriele Mayr, Isabella Friis Jørgensen, Maris Teder-Laving, Anne Heidi Skogholt,...> ;Gut. 2021 Apr 22
• 19 citations
  Mechanotransduction in gastrointestinal smooth muscle cells: Role of mechanosensitive ion channels.
  Vikram Joshi, Peter R. Strege, Gianrico Farrugia, Arthur Beyder> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2021 Mar 17
• 8 citations
  Gastric ablation as a novel technique for modulating electrical conduction in the in vivo stomach.
  Zahra Aghababaie, Niranchan Paskaranandavadivel, Satya Amirapu, Chih Hsiang Alexander Chan, Peng Du, Samuel J. Asirvatham, Gianrico Farrugia, Arthur Beyder, Gregory O'...> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2021 Apr 1
• 4 citations
  A simple automated approach to measure mouse whole gut transit
  Halil Kacmaz, Alecia Alto, Kaitlyn R. Knutson, David R. Linden, Simon J. Gibbons, Gianrico Farrugia, Arthur Beyder> ;Neurogastroenterology and Motility. 2021 Feb 1
• 6 citations
  Identification of intrinsic primary afferent neurons in mouse jejunum.
  Carina Guimarães de Souza Melo, Evan N. Nicolai, Constanza Alcaino, Tiffany J. Cassmann, Sara T. Whiteman, Alec M. Wright, Katie E. Miller, Simon J. Gibbons, Arthur Be...> ;Neurogastroenterology and Motility. 2020 Sep 28
• 11 citations
  NACHO and 14-3-3 promote expression of distinct subunit stoichiometries of the α4β2 acetylcholine receptor.
  Simone Mazzaferro, Sara T. Whiteman, Constanza Alcaino, Arthur Beyder, Steven M. Sine> ;Cellular and Molecular Life Sciences. 2021 Feb 1
• 18 citations
  microRNA overexpression in slow transit constipation leads to reduced NaV1.5 current and altered smooth muscle contractility
  Amelia Mazzone, Peter R. Strege, Simon J. Gibbons, Constanza Alcaino, Vikram Joshi, Andrew J. Haak, Daniel J. Tschumperlin, Cheryl E. Bernard, Robert R. Cima, David W....> ;Gut. 2020 May 1
• TRPPing up bronchiectasis.
  Arnaldo Mercado-Perez, Arthur Beyder> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2019 Oct 1
• 3 citations
  Telocytes express ANO-1-encoded chloride channels in canine ventricular myocardium.
  Christopher V. DeSimone, Christopher J. McLeod, Pedro J. Gomez Pinilla, Arthur Beyder, Gianrico Farrugia, Samuel J. Asirvatham, Suraj Kapa> ;Journal of Arrhythmia. 2019 Jun 1
• 10 citations
  SCN5A mutation G615E results in NaV1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity.
  Peter R. Strege, Arnaldo Mercado-Perez, Amelia Mazzone, Yuri A. Saito, Cheryl E. Bernard, Gianrico Farrugia, Arthur Beyder> ;Channels. 2019 Jul 2
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Journal Articles

• A Population of Gut Epithelial Enterochromaffin Cells Is Mechanosensitive and Requires Piezo2 to Convert Force into Serotonin Release  
  Arthur Beyder, Gianrico Farrugia, Andrew B Leiter, Proceedings of the National Academy of Sciences
• Chronic passive venous congestion drives hepataic fibrogenesis via sinusoidal thrombosis and mechanical forces.  
  Simonetto DA, Yang HY, Yin M, deAssuncao TM, Lwpm JH,Hilsher M, Pan S, Yang L, Bi Y, Beyder A, Cao S, Simari RD, Ehman R, Kamath PS, Shah VH, Gastroenterology, 8/20/2014
• Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces  
  Simonetto DA, Yang HY, Yin M, deAssuncao TM, Kwon JH, Hilsher M, Pan S, Yang L, Bi Y, Beyder A , Cao S, Simari RD, Ehman R, Kamath PS, Shah VH, Hepatology, 8/1/2014
• The bioelectrical basis and validity of gastrointestinal extracellular slow wave recordings  
  Angeli TR, Du P, Paskaranandavadivel N, Janssen PW, Beyder A , Lentle RG, Bissett IP, Cheng LK, O'Grady G, J Physiol, 9/1/2013
• Ranolazine inhibits shear sensitivity of endogenous Na+ current and spontaneous action potentials in HL-1 cells  
  Strege P, Beyder A , Bernard C, Crespo-Diaz R, Behfar A, Terzic A, Ackerman M, Farrugia G, Channels, 11/1/2012
• Membrane permeable local anesthetics modulate Na(V)15 mechanosensitivity  
  Beyder A , Strege PR, Bernard C, Farrugia G, Channels, 7/1/2012
• T-type Ca2+ channel modulation by otilonium bromide  
  Strege PR, Lei S, Beyder Am , Bernard CE, Perez-Reyes E, Evengelista S, Gibbons SJ, Szurszewski JH, Farrugia G, Am J Physiol Gastrointest Liver Physiol, 5/1/2010
• Hydrodynamics of torsional probes for Atomic Force Microscopy in liquids  
  Basak S, Beyder A , Raman A, Sachs F, J Appl Phys, 1/1/2007
• Symmetrically supported torsion levers remove probe dependent AFM drift  
  Beyder A , Spagnoli C, Sachs F, Rev Sci Instrum, 1/1/2006
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Books/Book Chapters

• New Advances in Gastrointestinal Motility 
  Chapter: Role of ion channel mechanosensitivity in gut mechano-electrical feedback exemplified by stretch dependence of Nav1.5 
  Beyder A , Lees-Green R, Farrugia GEditors: Cheng LK, Pullan AJ, Farrugia G.Springer, New York2012
• Scanning Probe Microscopy of Functional Materials 
  Chapter: Combined voltage-clamp and atomic force microscope for the study of membrane electromechanics 
  Beyder A , Sachs FEditors: Kalinin SV, Gruverman A.New York2010

Abstracts/Posters

• Shear sensitivity of the voltage-gated sodium selective ion channels (nav) in the neuroendocrine cell line qgp-1
  Beyder A , Strege P, Rainey J, Bernard C, Giandomenico V, Kashyap P, Farrugia G, Neurogastroenterol Motil, 9/1/2014
• Shear sensitivity of the voltage-gated sodium selective ion channels (NaV) in the neuroendocrine cell line QGP-1
  Beyder A, Digestive Diseases Week, Chicago, IL, 5/1/2014
• Bedside to Bench to Bedside: Individualizing Diagnosis and Therapy for Irritable Bowel Syndrome
  Beyder A, CCaTS Grand Rounds, Mayo Clinic, Rochester, MN, 3/1/2014
• Missense Mutations in SCN5A From Patients With Irritable Bowel Syndrome Result in Abnormal Nav1.5 Function
  Beyder A, Digestive Diseases Week, San Diego, CA, 5/1/2012
• Voltage-gated sodium selective ion channel Na v 1.5 channelopathy in some patients with IBS
  Beyder A, Mayo Clinic Membrane Receptor/Ion Channels Scientific Conference, Rochester, MN, 2/1/2012
• Lidocaine decreases stretch sensitivity of Nav1.5
  Beyder A, Biophysical Society Meeting, San Diego, CA, 1/1/2012
• Mutations in SCN5A from patients with IBS result in abnormal Nav1.5 function
  Beyder A, Digestive Diseases Week, Chicago, IL, 5/1/2011
• Altered expression of ANO1 variants in diabetes and in gastroparesis
  Beyder A, Digestive Diseases Week, Chicago, IL, 5/1/2011
• Ranolazine decreases excitability and inhibits mechanosensitivity of Nav1.5
  Beyder A, New Advances in GI Motility Workshop, Auckland, New Zealand, 1/1/2011
• Mechanosensitivity of Nav1.5, an ion channel found in the gastrointestinal system
  Beyder A, Digestive Diseases Week, New Orleans, LA, 5/1/2010
• A voltage-gated sodium selective channel Nav1.5 found in the gastrointestinal tract alters voltage sensitivity with direct stretch
  Beyder A, Joint International Neurogastroenterology and Motility Meeting, Boston, MA, 1/1/2010
• Mechanosensitivity of Nav1.5.
  Beyder A, Mayo Clinic Young Investigator Research Symposium, Rochester, MN, 1/1/2010
• Sodium channel mutations in Irritable Bowel Syndrome
  Beyder A, Neurogastroenterology and Motility, Chicago, IL, 1/1/2009
• Finite element modeling of torsional composite AFM probes
  Beyder A, Biophysical Journal, Baltimore, MD, 1/1/2007
• AFM studies of cell volume and stiffness during osmotic swelling
  Beyder A, Biophysical Journal, Salt Lake City, UT, 1/1/2006
• Torsion probes for liquid AFM with picoNewton sensitivity
  Beyder A, Cornell NanoScale Facility Annual Meeting, Ithaca, NY, 1/1/2005
• Calcium influx in the absence of Ca2+
  Beyder A, Biophysical Journal, San Francisco, CA, 1/1/2002
• Novel Cantilever design for atomic force microscopy
  Beyder A, Biophysical Journal, Boston, MA, 1/1/2001
• A novel bio-atomic force microscope cantilever
  Beyder A, NIH Bioengineering Consortium, Bethesda, MD, 1/1/2000
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Lectures

• Sheer sensitivity of the voltage-gated sodium selective ion channels (NaV) in the neuroendocrine cell liine QGP-1 
  Guangzhou, China - 9/1/2014
• Smooth Muscle Cell and Iinterstitial Cell of Cajal Mechanosensitivity 
  Guangzhou, China - 9/1/2014
• Voltage gated sodium selective ion channel NaV1.5 mechanosensitivity is modulated by ranolazine and membrane permeable local anesthetics 
  Oxford, United Kingdom - 9/1/2013
• Voltage-sensitive ion channels as mechanosensors exemplified by a mechanosensitive voltage gated sodium channel Nav1.5. 
  University of Auckland, Auckland, New Zealand - 11/1/2011
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