EricKarlRichfieldMD

PubMed

• 9 citations
  Molecular layer heterotopia of the cerebellar vermis in mutant and transgenic mouse models on a C57BL/6 background.
  Raddy L. Ramos, Sarah E. Van Dine, Elizabeth George, Dhruv B. Patel, Blair J. Hoplight, Joerg R. Leheste, Eric K. Richfield, German Torres> ;Brain Research Bulletin. 2013 Aug 1
• 15 citations
  Neuronal migration defect of the developing cerebellar vermis in substrains of C57BL/6 mice: cytoarchitecture and prevalence of molecular layer heterotopia.
  Zareema Mangaru, Elsaid Salem, Matthew Sherman, Sarah E. Van Dine, Ankur Bhambri, Joshua C. Brumberg, Eric K. Richfield, Lisa A. Gabel, Raddy L. Ramos> ;Developmental Neuroscience. 2013 Jun 12
• 39 citations
  Critical Role of Truncated α-Synuclein and Aggregates in Parkinson's Disease and Incidental Lewy Body Disease
  Kavita Prasad, Thomas G. Beach, John C. Hedreen, Eric K. Richfield> ;Brain Pathology. 2012 Nov 1
• 31 citations
  Genetic-based, differential susceptibility to paraquat neurotoxicity in mice.
  Lina Yin, Lu-De Lu, Kavita Prasad, Eric K. Richfield, Erica L. Unger, Jialin Xu, Byron C. Jones> ;Neurotoxicology and Teratology. 2011 May 1
• 15 citations
  Neocortical molecular layer heterotopia in substrains of C57BL/6 and C57BL/10 mice.
  Danielle M. Lipoff, Ankur Bhambri, Georgia J. Fokas, Sanjeev Sharma, Lisa A. Gabel, Joshua C. Brumberg, Eric K. Richfield, Raddy L. Ramos> ;Brain Research. 2011 May 19
• 14 citations
  Biochemical and morphological consequences of human α-synuclein expression in a mouse α-synuclein null background.
  Kavita Prasad, Elizabeth Tarasewicz, Pamela Ohman Strickland, Michael J. O'Neill, Stephen N. Mitchell, Kalpana M. Merchant, Samnang Tep, Kathryn Hilton, Akash Datwani,...> ;The European Journal of Neuroscience. 2011 Feb 1
• 14 citations
  Number and nuclear morphology of TH+ and TH− neurons in the mouse ventral midbrain using epifluorescence stereology
  Kavita Prasad, Eric K. Richfield> ;Experimental Neurology. 2010 Oct 1
• 20 citations
  Quantification of Paraquat, MPTP, and MPP+ in brain tissue using microwave-assisted solvent extraction (MASE) and high-performance liquid chromatography-mass spectrome...
  Bozena Winnik, Dana B. Barr, Mona Thiruchelvam, M. Angela Montesano, Eric K. Richfield, Brian Buckley> ;Analytical and Bioanalytical Chemistry. 2009 Jul 19
• 75 citations
  Toxicokinetics and toxicodynamics of paraquat accumulation in mouse brain
  Kavita Prasad, Elizabeth Tarasewicz, Jason Mathew, Pamela Ohman Strickland, Brian Buckley, Jason R. Richardson, Eric K. Richfield> ;Experimental Neurology. 2009 Feb 1
• 113 citations
  Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis
  Deborah J. Stumpo, Hal E. Broxmeyer, Toni Ward, Scott Cooper, Giao Hangoc, Yang Jo Chung, William C. Shelley, Eric K. Richfield, Manas K. Ray, Mervin C. Yoder, Peter D...> ;Blood. 2008 Nov 16
• 10 citations
  Sporadic midbrain dopamine neuron abnormalities in laboratory mice.
  Kavita Prasad, Eric K. Richfield> ;Neurobiology of Disease. 2008 Nov 1
• 79 citations
  Prolonged toxicokinetics and toxicodynamics of paraquat in mouse brain.
  Kavita Prasad, Bozena Winnik, Mona Thiruchelvam, Brian Buckley, Oleg Mirochnitchenko, Eric K. Richfield> ;Environmental Health Perspectives. 2007 Oct 1
• 124 citations
  The gestational environment and Parkinson's disease: evidence for neurodevelopmental origins of a neurodegenerative disorder.
  Brian K. Barlow, Deborah A. Cory-Slechta, Eric K. Richfield, Mona Thiruchelvam> ;Reproductive Toxicology. 2007 Apr 1
• 62 citations
  Proteasome dysfunction in aged human α-synuclein transgenic mice
  Li Chen, Mona Thiruchelvam, Kiran Madura, Eric K. Richfield> ;Neurobiology of Disease. 2006 Jul 1
• 86 citations
  Developmental Pesticide Models of the Parkinson Disease Phenotype
  Deborah A. Cory-Slechta, Mona Thiruchelvam, Brian K. Barlow, Eric K. Richfield> ;Environmental Health Perspectives. 2005 Sep 1
• 70 citations
  Zfp36l3, a Rodent X Chromosome Gene Encoding a Placenta-Specific Member of the Tristetraprolin Family of CCCH Tandem Zinc Finger Proteins
  Perry J. Blackshear, Ruth S. Phillips, Sanjukta Ghosh, Silvia V.B. Ramos, Eric K. Richfield, Wi S. Lai> ;Biology of Reproduction. 2005 Aug 1
• 105 citations
  Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype.
  Mona Thiruchelvam, Olga Prokopenko, Deborah A. Cory-Slechta, Eric K. Richfield, Brian Buckley, Oleg Mirochnitchenko> ;The Journal of Biological Chemistry. 2005 Jun 10
• 40 citations
  Developmental pesticide exposures and the Parkinson's disease phenotype.
  Deborah A. Cory-Slechta, Mona Thiruchelvam, Eric K. Richfield, Brian K. Barlow, Andrew I. Brooks> ;Birth Defects Research. Part A, Clinical and Molecular Teratology. 2005 Mar 1
• 95 citations
  EIF2B5 mutations compromise GFAP + astrocyte generation in vanishing white matter leukodystrophy
  Jorg Dietrich, Michelle Lacagnina, David Gass, Eric K. Richfield, Margot Mayer-Pröschel, Mark Noble, Carlos F. Torres, Christoph Pröschel> ;Nature Medicine. 2005 Feb 20
• 58 citations
  A Fetal Risk Factor for Parkinson’s Disease
  Brian K. Barlow, Eric K. Richfield, Deborah A. Cory-Slechta, Mona Thiruchelvam> ;Developmental Neuroscience. 2004 Oct 22
• 9 citations
  The effect of developmental exposure to the fungicide triadimefon on behavioral sensitization to triadimefon during adulthood.
  R. Reeves, Mona Thiruchelvam, Eric K. Richfield, Deborah A. Cory-Slechta> ;Toxicology and Applied Pharmacology. 2004 Oct 1
• 32 citations
  Heritability, correlations and in silico mapping of locomotor behavior and neurochemistry in inbred strains of mice.
  T. R. Mhyre, Elissa J. Chesler, M. Thiruchelvam, Codrin Lungu, Deborah A. Cory-Slechta, J. D. Fry, Eric K. Richfield> ;Genes, Brain, and Behavior. 2004 Sep 29
• 125 citations
  Risk factors for dopaminergic neuron loss in human alpha-synuclein transgenic mice.
  Mona Thiruchelvam, J. M. Powers, Deborah A. Cory-Slechta, Eric K. Richfield> ;The European Journal of Neuroscience. 2004 Feb 1
• 22 citations
  Behavioral sensitization and long-term neurochemical alterations associated with the fungicide triadimefon
  R. Reeves, Mona Thiruchelvam, Eric K. Richfield, Deborah A. Cory-Slechta> ;Pharmacology, Biochemistry, and Behavior. 2003 Sep 1
• 195 citations
  Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype.
  Mona Thiruchelvam, Alison L. McCormack, Eric K. Richfield, Raymond B. Baggs, A. William Tank, Donato A. Di Monte, Deborah A. Cory-Slechta> ;The European Journal of Neuroscience. 2003 Aug 1
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Journal Articles

• Pictet-Spengler condensations in refluxing benzene.  
  Sandrin, J., Richfield. E.K., Hutchins, L., Cook, J.M, Heterocycles 4(6): 1101-1105
• Review of automated analytical techniques in electromyography.  
  Richfield, E.K., Cohen, B.A., Albers, J.W, IEEE Journal of Biomedical Engineering, Vol. BME-26(7):505-514.
• Preferential localization of [3H]-sulpiride binding sites to striatum and ventral striatum in rat brain.  
  Ryan-Jastrow, T., Richfield, E.K., Gnegy, M, Neuroscience Letters 51:47-53
• Properties of D-2 dopamine receptor autoradiography: High percentage of high affinity agonist sites and increased nucleotide sensitivity in tissue sections.  
  Richfield, E.K., Young, A.B., Penney, J.B, Brain Research 383:121-128
• The distribution of D-1 and D-2 dopamine receptors in the basal ganglia of turtles, pigeons, rats, cats, and monkeys.  
  Richfield, E.K., Young, A.B., Penney, J.B, Journal of Comparative Neurology 262:446-463.
• Neurologic syndrome following bilateral destruction of the head of the caudate nuclei.  
  Richfield, E.K., Twyman, R. and Berent, S, Annals of Neurology 22:768-771
• Comparison of [14C]-deoxyglucose metabolism and peripheral benzodiazepine receptor binding in rats with C6 glioma.  
  Richfield, E.K., Ciliax, B. J., Starosta-Rubenstein, S. R., McKeever, P.E., Penney, J.B, Young, A.B, Neurology 38:1255-1262
• cortical distribution of D-1 and D-2 receptors in rats, cats, and monkeys.  
  Richfield, E.K., Young, A.B., Penney, J.B, Journal of Comparative Neurology 286:409-426
• Heterogeneous pattern of dopamine D-1 and D-2 receptors in human ventral striatum.  
  Berendse, H. and Richfield, E.K., Neuroscience Letters 150:75-79
• The distribution of GABAA, GABAB, and benzodiazepine receptors in the forebrain and midbrain of pigeons.  
  Veenman, C. L., Albin, R. L., Richfield, E. K., and Reiner, A, Journal of Comparative Neurology 344:161-189
• The relationship of essential tremor to other movement disorders: Report on 678 patients.  
  Koller, W.C., Busenbark, K., Miner, K., and the Essential Tremor Study Group, Annals of Neurology 35:717-723
• Chronic treatment with typical and atypical antipsychotics increase the AMPA-preferring form of the AMPA receptor in rat brain.  
  McCoy, L. and Richfield, E.K, European Journal of Pharmacology 318:41-45
• Regional decreases in 3H-AMPA and 3H-CNQX binding in response to chronic low-level lead exposure: Reversal vs potentiation by chronic dopamine agonist treatment.  
  McCoy, L., Richfield, E.K. and Cory-Slechta, D.A, Journal of Neurochemistry 69:2466-2476
• Selective loss of preprotachykinin neurons in a phenocopy of Huntington’s disease.  
  Richfield, E.K., Vonsattel, J.P., MacDonald, M.E., Sun, Z., Deng, Y-P.P., Reiner, A, Movement Disorders 17(2):327-332
• Selective dithiocarbamates increase synaptosomal dopamine content, brain concentration of paraquat and correlate with potentiation of MPTP and paraquat toxicity.  
  Barlow, B.B., Bennice, L., Thiruchelvam, M.J., Cory-Slechta, D.A., Ballatori, N., and Richfield, E.K, Journal of Neurochemistry 85:1075-86
• Age-related irreversible nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson’s disease phenotype.  
  Thiruchelvam, M., McCormack, A., Richfield, E.K., Baggs, R., Tank, A.W., Di Monte, D.A., and Cory-Slechta, D.A, Eur. J. of Neuroscience 18:589-600
• Neuroprotection against paraquat and maneb induced dopaminergic toxicity in transgenic mice overexpressing superoxide dismutase and glutathione peroxidase.  
  Thiruchelvamm M., Prokopenko. O., Cory-Slechta, D.A., Richfield, E.K., Mirochnitchenko, O, J. Biol. Chem. 280(23): 22530-22539
• Real time epifluorescence stereology and morphology of neurons in the mouse substantia nigra and ventral tegmental area.  
  Prasad, K. and Richfield, E.K, Experimental Neurology 225:328-340
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Books/Book Chapters

• Receptor autoradiography in Parkinson's disease 
  Chapter: Recent Developments in Parkinson's Disease 
  Penney, J.B., Richfield, E.K., Young, A.BEditors: Fahn, S., Marsden, C.D., Calne, D., Goldstein, M. Macmillan: Florham Park, N.J.
• Anatomical and pharmacological comparisons between dopamine D-1 and D-2 receptors in the mammalian central nervous system 
  Chapter: Progress in Parkinson Research 
  Richfield, E.K., Penney, J.B., and Young, A.BEditors: Hefti, F.F. and Weiner, W.J.Plenum Press, New York
• The mesolimbic motor circuit in Parkinson’s disease and other movement disorders 
  Richfield, E.KEditors: The Mesolimbic Motor Circuit and its Role in Neuropsychiatric Disorders.

Abstracts/Posters

• Autoradiographic localization of amino acid neurotransmitter receptors in the cerebellar cortex of pigeon (Columba livia) and turtle (Psuedmys scripta).
  Albin, R.L., Richfield, E.K., Reiner, A., Young, A.B., and Penney, J.B, Soc. for Neuroscience Abstr. 19
• Distribution of mu, delta, and kappa opioid receptor subtypes in the rat spinal cord.
  Romagnano, M.A., Richfield, E.K., Brady, L.S., and Hamill, R.W, Soc. for Neuroscience Abstr. 19
• Anatomical distribution and pharmacology of the dopamine uptake complex in rat and man.
  Richfield, E.K. and Farrell, K, Soc. for Neuroscience Abstr. 20
• Heterogeneous dopamine receptor changes in early and late Huntington’s disease.
  Richfield, E.K., O’Brien, C., Eskin, T, American Academy of Neurology
• Regulation of binding to the dopamine uptake complex by metal cations.
  Richfield, E.K., Soc. for Neuroscience Abstr. 21
• Preservation of the density of the dopamine uptake complex in aging rat brain.
  Inglefield, J.I. and Richfield, E.K, Soc. for Neuroscience Abstr. 21
• Kappa opioid receptor subtype in rat spinal cord: Coincidence with autonomic regions.
  Romagnano, M.A., Richfield, E.K., Brady, L.S. and Hamill, R.W, Soc. for Neuroscience Abstr. 21
• a1-Adrenergic receptor density and norepinephrine levels in aging and Alzheimer’s disease.
  Li, Z.W., Romagnano, M., Richfield, E.K., Cousins, L., and Hamill, R.W, Soc. for Neuroscience Abstr. 22
• M.-F. In situ nick translation identifies DNA degradation in HD putamen
  MacKenzie, L., Richfield, E.K., and Chesselet, 15th International World Federation of Neurology Workshop on Huntington’s disease, Waltham, MA
• Hadjconstantinou, M. Striatal dopamine and its relationship to open field motor behavior in normal rats.
  McCoy, L., Schwarzkopf, S.B., Richfield, E.K, Soc. for Neuroscience Abstr. 23
• Mechanism of action of zinc on the dopamine uptake carrier.
  Zuch, C.L., Gilmore, J.L., and Richfield, E.K, Society of Toxicology
• Hyperactivity and reduction in sustained behavior following perinatal hypoxia.
  McCoy, L., Schwartzkopf, S.B., and Richfield, E.K, Soc. of Biol. Psychiatry
• Reduced expression of preproenkephalin in striatal neurons from Huntington’s disease.
  Richfield, E.K., Magiure, K., Cox, C., Gilmore, J., and Voorn, P, American Neurological Association
• Regional heterogeneity in agonist enhanced [3H]MK 801 binding following variable prewash conditions in rat brain.
  McCoy, L. and Richfield, E.K, Soc. for Neuroscience Abstr. 25
• Effects of typical and atypical antipsychotics on Non-NMDA Receptor Binding.
  McCoy, L. and Richfield, E.K, Society for Neuroscience Abst
• Regional effects of chronic lead exposure on MK-801 and AMPA binding in rat brain.
  Richfield, E.K., McCoy, L., and Cory-Slechta, D.A, Society for Neuroscience Abst
• A rodent model of occupational Pb exposure: Alterations in behavior and dopamine systems.
  Brockel, B.J., Walter, J.J., Richfield, E.K., and Cory-Slechta, D.A, Society for Neuroscience Abst
• Chronic exposure to paraquat and maneb: Effects on nigrostriatal dopaminergic system and implications for Parkinson’s disease.
  Thiruchelvam, M., Richfield, E.K., Baggs, R., Tank, A.W., and, Cory-Slechta, D.A, Society for Neuroscience Abst
• Altered dopamine terminals and enhanced vulnerability to MPTP in wild-type and mutated human alpha–synuclein transgenic mice.
  Richfield, E.K., Cory-Slechta, D.A, Society for Neuroscience Abst
• Age related and irreversible nigrostriatal dopamine system neurotoxicity of combined exposure to paraquat and maneb.
  Thiruchelvam M, Richfield EK, Tank AW, Baggs R, McCormack AL, Di Monte DA, Cory-Slechta DA, The Toxicologist, Vol 60 (1), p.54
• Age-dependent and progressive nigrostriatal dopaminergic neurotoxicity of paraquat.
  Cory-Slechta DA, Thiruchelvam M, Richfield EK, Thiffault C, Di Monte DA, The Toxicologist, Vol 60 (1), p.54
• In vitro augmentation of dopamine uptake by fungicides.
  Barlow, BK, Thiruchelvam, M, Cory-Slechta, DA, and Richfield EK, NTX XIX: Nineteenth International Neurotoxicology Conference
• Physiologic and pathologic features of wild-type and mutated human alpha-synuclein in transgenic mice.
  Richfield, E.K., Thiruchelvam, M., Wuertzer, C.A., Cory-Slechta, D.A, and Federoff, H.J, NTX XIX: Nineteenth International Neurotoxicology Conference
• Effect of combined exposure to paraquat and maneb in transgenic mice expressing human wild-type or doubly mutant alpha–synuclein: Gene-environment interactions in Park...
  Thiruchelvam, M., Richfield, E.K., Federoff, H.J. and, Cory-Slechta, D.A, Society for Neuroscience Abst
• Effect of combined exposure to paraquat and maneb in transgenic mice expressing human wild-type or doubly mutant alpha–synuclein: Gene-environment interactions in Park...
  Thiruchelvam, M., Richfield, E.K., Federoff, H.J. and, Cory-Slechta, D.A, Society for Neuroscience Abst
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Lectures

• The Human Ventral Striatum in Neurology and Psychiatry. 
  Neurology Grand Rounds, University of Tennessee, Memphis
• Pharmacology and Anatomy of the Dopamine Uptake Complex. 
  Neurobiology and Anatomy Seminar, University of Tennessee, Memphis.
• Delirium and dementia. 
  Geriatric medicine review course, University of Rochester
• Zinc and the dopamine transporter. 
  Pharmacology seminar series, University of Rochester
• Zinc and the central nervous system. 
  Neurology Resident basic science seminar series, University of Rochester.
• Molecular Neuropathology of Huntington’s Disease. 
  Genentech, Inc., San Francisco, CA
• Anatomical and pharmacological comparisons between dopamine D-1 and D-2 receptors in the mammalian central nervous system. 
  First National Parkinson Foundation Meeting on Parkinson Research, Miami, FL.
• Physiologic and Pathologic Effects of Human –Synuclein Transgenic Mice, Nineteenth International Neurotoxicology Conference: Parkinson’s disease, Environment, and Genes. 
  Colorado Springs, CO
• Distribution of dopamine terminals and receptors in primate cerebral cortex. 
  Neuroscience seminar series, University of Michigan
• Physiologic and Pathologic Effects of Human –Synuclein Transgenic Mice. 
  Massachusetts General Hospital Neuroscience Seminar Series, Boston, MA.
• Dopamine receptors in neurologic disorders. 
  Neurology Resident basic science seminar series, University of Rochester.
• Mechanisms of Dithiocarbamates and Paraquat in Neurotoxicant Parkinsonism. 
  Environmental Medicine Grant Rounds, University of Rochester, Rochester, NY
• Glutamate, aspartate, and excitotoxins in neurologic disorders. 
  Neurology Resident basic science seminar series, University of Rochester.
• Mechanisms of Dithiocarbamates and Paraquat in Neurotoxicant Parkinsonism. 
  Twentieth International Neurotoxicology Conference: Little Rock, AR.
• Anatomy and Pharmacology of the Human Ventral Striatum. 
  Neurology Grand Rounds, University of Rochester.
• Transgenic Human –Synuclein Transgenic Mice. 
  Pathology Grand Rounds, University of California, Davis, Sacramento, CA.
• Pesticides, Transporters and the Parkinson’s Disease Phenotype: You Are What You Ate? 
  Neurology Grand Rounds, University of California, Davis, Sacramento, CA.
• Heritability and Correlations of Locomotor Behaviors and Neurochemistry in Inbred Strains of Mice. 
  New Paradigms for Exploring Gene-Environment-Behavior Relationships, NIEHS, Research Park Triangle,
• The Parkinson's disease Phenotype: Risk Factors, Models, and Mechanisms. 
  Sun Health Research Institute, Sun City, AZ.
• Alpha-Synuclein: From risk factor to model, mechanism, and targeted neuroprotection in Parkinson's disease. 
  University of Florida, Gainesville, FL
• Tardive Syndromes. 
  Geriatric Grand Rounds, Monroe Community Hospital
• Alpha-Synuclein: From risk factor to model, mechanism, and targeted neuroprotection in Parkinson's disease, Elan Pharmaceuticals. 
  South San Francisco, CA
• Parkinson's disease Phenotype in Man and Mouse. 
  Pathology Grand Rounds, UMDNJ, Newark, NJ
• Mouse Models for Translation Research in Parkinson’s disease. 
  Multiple locations, 2008
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